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Ate1 Gene Detail
Summary
  • Symbol
    Ate1
  • Name
    arginyltransferase 1
  • Synonyms
    Ate1_1, Ate1_2, Ate1_3, Ate1_4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333870
    NCBI Gene: 11907
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:130391493-130520369 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      128877 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 73.19 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ATE1, arginyltransferase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ATE1, arginyltransferase 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 11101
    neXtProt AC: NX_O95260
    UniProt: O95260

  • Chr Location
    10q26.13; chr10:121740421-121928801 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    55 phenotypes from 4 alleles in 6 genetic backgrounds
    6 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in developmental defects of the heart and embryonic lethality between E13.5 and E15.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000059393 VEGA Gene Model | MGI Sequence Detail 128877 C57BL/6J ±  kb
    transcript OTTMUST00000145788 VEGA | MGI Sequence Detail 4685 Not Applicable  
    polypeptide OTTMUSP00000075959 VEGA | MGI Sequence Detail 516 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      563 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 105
      cDNA 104
      Other 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:2141882, MGI:2142257
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:51609 Kwon YT, et al., Alternative splicing results in differential expression, activity, and localization of the two forms of arginyl-tRNA-protein transferase, a component of the N-end rule pathway. Mol Cell Biol. 1999 Jan;19(1):182-93
    • Latest
      J:249298 Wang J, et al., Arginyltransferase ATE1 is targeted to the neuronal growth cones and regulates neurite outgrowth during brain development. Dev Biol. 2017 Oct 1;430(1):41-51

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory