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Tnnt1 Gene Detail
Summary
  • Symbol
    Tnnt1
  • Name
    troponin T1, skeletal, slow
  • Synonyms
    skeletal muscle slow-twitch TnT, ssTnT, sTnT, Tnt
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333868
    NCBI Gene: 21955
  • Gene Overview
    MyGene.info: TNNT1
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:4504569-4516000 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 2.60 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    71 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333868
protein coding gene Chr7:4504569-4516382 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031547
protein coding gene Chr7:1418785-1431947 (-)
A/J MGP_AJ_G0031521
protein coding gene Chr7:1424299-1435832 (-)
AKR/J MGP_AKRJ_G0031450
protein coding gene Chr7:1500451-1513807 (-)
BALB/cJ MGP_BALBcJ_G0031529
protein coding gene Chr7:1490243-1501889 (-)
C3H/HeJ MGP_C3HHeJ_G0031250
protein coding gene Chr7:1462279-1473685 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031990
protein coding gene Chr7:1452003-1465407 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029114
protein coding gene Chr7:1193637-1205500 (-)
CAST/EiJ MGP_CASTEiJ_G0030614
protein coding gene Chr7:1399866-1413447 (-)
CBA/J MGP_CBAJ_G0031208
protein coding gene Chr7:1653547-1665168 (-)
DBA/2J MGP_DBA2J_G0031367
protein coding gene Chr7:1386768-1398887 (-)
FVB/NJ MGP_FVBNJ_G0031319
protein coding gene Chr7:1370008-1381604 (-)
LP/J MGP_LPJ_G0031452
protein coding gene Chr7:1513641-1527195 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031358
protein coding gene Chr7:1584772-1598150 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032020
protein coding gene Chr7:1402077-1413644 (-)
PWK/PhJ MGP_PWKPhJ_G0030342
protein coding gene Chr7:1564429-1584939 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030167
protein coding gene Chr7:1452911-1472534 (-)
WSB/EiJ MGP_WSBEiJ_G0030709
protein coding gene Chr7:1417503-1428983 (-)



Homology
more
  • Human Ortholog
    TNNT1, troponin T1, slow skeletal type
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TNNT1, troponin T1, slow skeletal type
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ANM, NEM5, STNT, TNT, TNTS
  • Links
    NCBI Gene ID: 7138
    neXtProt AC: NX_P13805
    UniProt: P13805

  • Chr Location
    19q13.42; chr19:55132698-55149354 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Tnnt1 mouse models; 1 with human TNNT1 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null or hypomorphic allele show small and loss of type I slow skeletal muscle fibers with compensatory hypertrophy of type II fast fibers and reduced contractile force and tolerance of skeletal muscle fibers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21955 NCBI Gene Model | MGI Sequence Detail 11432 C57BL/6J ±  kb
    transcript NM_001277903 RefSeq | MGI Sequence Detail 1030 C57BL/6  
    polypeptide O88346 UniProt | EBI | MGI Sequence Detail 262 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 5
      cDNA 26
      Primer pair 3
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2142213
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 27
      Diseases 1
      Gene Ontology 5
      Phenotypes 6
    • Earliest
      J:39609 Koch A, et al., cDNA cloning and chromosomal mapping of mouse fast skeletal muscle troponin T. Mamm Genome. 1997 May;8(5):346-8
    • Latest
      J:265811 Fox MD, et al., TNNT1 nemaline myopathy: natural history and therapeutic frontier. Hum Mol Genet. 2018 Sep 15;27(18):3272-3282

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/27/2018
    MGI 6.13
    The Jackson Laboratory