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Tnnt1
Gene Detail
Symbol

Name
ID
Tnnt1
troponin T1, skeletal, slow
MGI:1333868
Synonyms
skeletal muscle slow-twitch TnT, ssTnT, sTnT, Tnt
Feature Type
protein coding gene
Genetic Map
Chromosome 7
2.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr7:4504570-4516382 bp, - strand
From VEGA annotation of GRCm38

  11813 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20704  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TNNT1
Gene Tree: Tnnt1

Human
homologs
TNNT1, troponin T type 1 (skeletal, slow)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7138
neXtProt AC: NX_P13805

Human Synonyms: ANM, NEM5, STNT, TNT, TNTS

Human Chr (Location): 19q13.4; chr19:55132698-55149354 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TNNT1

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Tnnt1 interacts with 14 markers (Mir207, Mir326, Mir367, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process negative regulation of muscle contraction, regulation of muscle contraction, ...
Component troponin complex
Function tropomyosin binding, troponin T binding
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (24)    Tissues (11)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 24
cDNA source data(24)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tnnt1 ; ZFIN zgc:193865    NEW 
Molecular
reagents
All nucleic(32) Genomic(5) cDNA(24) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000036009 (Evidence)
Ensembl Gene Model ENSMUSG00000064179 (Evidence)
Entrez Gene 21955 (Evidence)
UniGene 358643
DFCI TC1642387, TC1595826, TC1585218, TC1701895
DoTS DT.87068663, DT.94396255, DT.94396257, DT.94396260
NIA Mouse Gene Index U028085
Consensus CDS Project CCDS51973.1, CCDS71879.1, CCDS71880.1
International Mouse Phenotyping Consortium Status Tnnt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036009 VEGA Gene Model | MGI Sequence Detail 11813 C57BL/6J ±  kb
transcript OTTMUST00000092406 VEGA | MGI Sequence Detail 1059 Not Applicable 
polypeptide OTTMUSP00000051064 VEGA | MGI Sequence Detail 262 Not Applicable 

For the selected sequences
All sequences(95) RefSeq(12) UniProt(11)
Polymorphisms
SNPs within 2kb(82 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001978 Troponin
Protein Ontology PR:000016508 troponin T, slow skeletal muscle
References
(Earliest) J:39609 Koch A, et al., cDNA cloning and chromosomal mapping of mouse fast skeletal muscle troponin T. Mamm Genome. 1997 May;8(5):346-8
(Latest) J:219907 Wei B, et al., Deficiency of slow skeletal muscle troponin T causes atrophy of type I slow fibres and decreases tolerance to fatigue. J Physiol. 2014 Mar 15;592(Pt 6):1367-80
All references(56)
Other
accession IDs
MGI:2142213

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory