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Tnnt1 Gene Detail
Summary
  • Symbol
    Tnnt1
  • Name
    troponin T1, skeletal, slow
  • Synonyms
    skeletal muscle slow-twitch TnT, ssTnT, sTnT, Tnt
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333868
    NCBI Gene: 21955
  • Gene Overview
    MyGene.info: TNNT1
Location & Maps
more
Homology
more
  • Human Ortholog
    TNNT1, troponin T1, slow skeletal type
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TNNT1, troponin T1, slow skeletal type
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ANM, NEM5, STNT, TNT, TNTS
  • Links
    NCBI Gene ID: 7138
    neXtProt AC: NX_P13805

  • Chr Location
    19q13.4; chr19:55132698-55149354 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Tnnt1 mouse models; 1 with human TNNT1 associations

Human Disease Mouse Models
       Nemaline Myopathy 5; NEM5   OMIM: 605355 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a null or hypomorphic allele show small and loss of type I slow skeletal muscle fibers with compensatory hypertrophy of type II fast fibers and reduced contractile force and tolerance of skeletal muscle fibers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036009 VEGA Gene Model | MGI Sequence Detail 11813 C57BL/6J ±  kb
transcript OTTMUST00000092406 VEGA | MGI Sequence Detail 1059 Not Applicable  
polypeptide OTTMUSP00000051064 VEGA | MGI Sequence Detail 262 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    75 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 32
    Genomic 5
    cDNA 24
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
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MGI:2142213
References
more
  • Summaries
    All 53
    Developmental Gene Expression 18
    Diseases 1
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:39609 Koch A, et al., cDNA cloning and chromosomal mapping of mouse fast skeletal muscle troponin T. Mamm Genome. 1997 May;8(5):346-8
  • Latest
    J:219907 Wei B, et al., Deficiency of slow skeletal muscle troponin T causes atrophy of type I slow fibres and decreases tolerance to fatigue. J Physiol. 2014 Mar 15;592(Pt 6):1367-80

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory