Rfxank
Gene Detail

Symbol Name ID

Rfxank regulatory factor X-associated ankyrin-containing protein MGI:1333865

Synonyms

Tvl1

Feature Type

protein coding gene

Genetic Map

Chromosome 8

34.15 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:70130812-70139197 bp, - strand From Ensembl annotation of GRCm38   8386 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2760  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: DNA-binding protein RFXANK
Gene Tree: Rfxank

Human homologs

Human Homolog		RFXANK, regulatory factor X-associated ankyrin-containing protein
NCBI Gene ID		8625
neXtProt AC		NX_O14593
Human Synonyms		ANKRA1, BLS, F14150_1, RFX-B
Human Chr (Location)		19p12; chr19:19303008-19312678 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human RFXANK

Alleles and phenotypes

All alleles(15) : Targeted(2) Gene trapped(13)

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	positive regulation of transcription from RNA polymerase II promoter, Ras protein signal transduction, ...
Component	cytoplasm, nucleus
Function	DNA binding, histone deacetylase binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (160)    Tissues (137)    Images (15)
Theiler Stages: 19, 22, 23, 28

Assay Type	Results
RNA in situ	160

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(18) cDNA(18)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000036120 (Evidence)
Entrez Gene	19727 (Evidence)
NIA Mouse Gene Index	U029908
Consensus CDS Project	CCDS22360.1
International Mouse Knockout Project Status	Rfxank

Sequences

Length	Strain/Species
genomic	ENSMUSG00000036120	Ensembl Gene Model | MGI Sequence Detail	8386	C57BL/6J
transcript	ENSMUST00000075724	Ensembl | MGI Sequence Detail	3676	Not Applicable
polypeptide	ENSMUSP00000075140	Ensembl | MGI Sequence Detail	269	Not Applicable

All sequences(28) RefSeq(4) UniProt(4)

Polymorphisms

SNPs(34 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002110	Ankyrin repeat
InterPro	IPR020683	Ankyrin repeat-containing domain
InterPro	IPR017362	DNA-binding, RFXANK
Protein Ontology	PR:000013930	DNA-binding protein RFXANK

References

(Earliest) J:50539 Masternak K, et al., A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients. Nat Genet. 1998 Nov;20(3):273-7
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(32)