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Arhgap31
Gene Detail
Symbol

Name
ID
Arhgap31
Rho GTPase activating protein 31
MGI:1333857
Synonyms
CdGAP, mKIAA1204
Feature Type
protein coding gene
Genetic Map
Chromosome 16
26.87 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:38598340-38713274 bp, - strand
From VEGA annotation of GRCm38

  114935 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10644  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Arhgap31

Human
homologs
Human Homolog ARHGAP31, Rho GTPase activating protein 31
NCBI Gene ID 57514
neXtProt AC  NX_Q2M1Z3
Human Synonyms  AOS1, CDGAP
Human Chr (Location)  3q13.33; chr3:119294289-119419476 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ARHGAP31
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Arhgap31 interacts with 342 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process positive regulation of GTPase activity, signal transduction, ...
Component cell junction, cell projection, ...
Function GTPase activator activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (30)    Tissues (19)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 30
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) Genomic(1) cDNA(16) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000023288 (Evidence)
Ensembl Gene ModelENSMUSG00000022799 (Evidence)
Entrez Gene12549 (Evidence)
DFCITC1709994, TC1633926, TC1655032, TC1643162, TC1646212
DoTSDT.87038641, DT.55145338, DT.91563869, DT.491164, DT.40175912
NIA Mouse Gene IndexU037040
Consensus CDS ProjectCCDS28172.1
International Mouse Knockout Project StatusArhgap31
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023288 VEGA Gene Model | MGI Sequence Detail 114935 C57BL/6J ±  kb
transcript OTTMUST00000056400 VEGA | MGI Sequence Detail 7964 Not Applicable 
polypeptide OTTMUSP00000027104 VEGA | MGI Sequence Detail 1425 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(537 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000198 Rho GTPase-activating protein domain
InterPro IPR008936 Rho GTPase activation protein
Protein Ontology PR:000005228 rho GTPase-activating protein 31
References
(Earliest) J:50532 Lamarche-Vane N, et al., CdGAP, a novel proline-rich GTPase-activating protein for Cdc42 and Rac. J Biol Chem. 1998 Oct 30;273(44):29172-7
(Latest) J:177944 Southgate L, et al., Gain-of-function mutations of ARHGAP31, a Cdc42/Rac1 GTPase regulator, cause syndromic cutis aplasia and limb anomalies. Am J Hum Genet. 2011 May 13;88(5):574-85
All references(41)
Other
accession IDs
MGI:1923377, MGI:2146575

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory