Arhgap31
Gene Detail

Symbol Name ID

Arhgap31 Rho GTPase activating protein 31 MGI:1333857

Synonyms

CdGAP, mKIAA1204

Feature Type

protein coding gene

Genetic Map

Chromosome 16

26.87 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr16:38598340-38713274 bp, - strand From VEGA annotation of GRCm38   114935 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Arhgap31 ± 2 cM)

Gene Tree: Arhgap31

Human ortholog

ARHGAP31 Rho GTPase activating protein 31 NCBI Gene ID 57514
Human Synonyms: AOS1, CDGAP
Human Chr3:119013220-119138323 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human ARHGAP31 (1)

Alleles and phenotypes

All alleles(3) : Targeted(3)

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	signal transduction, small GTPase mediated signal transduction
Component	cell junction, cell projection, ...
Function	GTPase activator activity, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (30)    Tissues (18)    Images (17)
Theiler Stages: 15, 17, 19, 20, 22, 24, 26, 28

Assay Type	Results
RNA in situ	30

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(18) Genomic(1) cDNA(16) Primer pair(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000023288 (Evidence)
Ensembl Gene Model	ENSMUSG00000022799 (Evidence)
Entrez Gene	12549 (Evidence)
DFCI	TC1633926, TC1643162, TC1646212, TC1655032, TC1709994
DoTS	DT.40175912, DT.491164, DT.55145338, DT.87038641, DT.91563869
NIA Mouse Gene Index	U037040
Consensus CDS Project	CCDS28172.1
International Mouse Knockout Project Status	Arhgap31

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023288	VEGA Gene Model | MGI Sequence Detail	114935	C57BL/6J
transcript	OTTMUST00000056400	VEGA | MGI Sequence Detail	7964	Not Applicable
polypeptide	OTTMUSP00000027104	VEGA | MGI Sequence Detail	1425	Not Applicable

All sequences(45) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(487 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000198	Rho GTPase-activating protein domain
InterPro	IPR008936	Rho GTPase activation protein
Protein Ontology	PR:000005228	cdc42 GTPase-activating protein

References

(Earliest) J:50532 Lamarche-Vane N, et al., CdGAP, a novel proline-rich GTPase-activating protein for Cdc42 and Rac. J Biol Chem. 1998 Oct 30;273(44):29172-7
(Latest) J:177944 Southgate L, et al., Gain-of-function mutations of ARHGAP31, a Cdc42/Rac1 GTPase regulator, cause syndromic cutis aplasia and limb anomalies. Am J Hum Genet. 2011 May 13;88(5):574-85
All references(41)

Other accession IDs

MGI:1923377, MGI:2146575