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Arhgap31 Gene Detail
Summary
  • Symbol
    Arhgap31
  • Name
    Rho GTPase activating protein 31
  • Synonyms
    CdGAP, mKIAA1204
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333857
    NCBI Gene: 12549
  • Gene Overview
    MyGene.info: ARHGAP31
Location & Maps
more
  • Sequence Map
    Chr16:38598340-38713274 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      114935 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 26.87 cM, cytoband B4
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ARHGAP31, Rho GTPase activating protein 31
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ARHGAP31, Rho GTPase activating protein 31
    Orthology source: HomoloGene
  • Synonyms
    AOS1, CDGAP
  • Links
    NCBI Gene ID: 57514
    neXtProt AC: NX_Q2M1Z3

  • Chr Location
    3q13.33; chr3:119294289-119419476 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human ARHGAP31 associations

Human Disease Mouse Models
       Adams-Oliver Syndrome 1; AOS1   OMIM: 100300
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023288 VEGA Gene Model | MGI Sequence Detail 114935 C57BL/6J ±  kb
transcript OTTMUST00000056400 VEGA | MGI Sequence Detail 7964 Not Applicable  
polypeptide OTTMUSP00000027104 VEGA | MGI Sequence Detail 1425 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    536 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000005228 rho GTPase-activating protein 31
  • InterPro Domains
    IPR000198 Rho GTPase-activating protein domain
    IPR008936 Rho GTPase activation protein
Molecular
Reagents
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  • All nucleic 18
    Genomic 1
    cDNA 16
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
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MGI:1923377, MGI:2146575
References
more
  • Summaries
    All 35
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 3
  • Earliest
    J:50532 Lamarche-Vane N, et al., CdGAP, a novel proline-rich GTPase-activating protein for Cdc42 and Rac. J Biol Chem. 1998 Oct 30;273(44):29172-7
  • Latest
    J:177944 Southgate L, et al., Gain-of-function mutations of ARHGAP31, a Cdc42/Rac1 GTPase regulator, cause syndromic cutis aplasia and limb anomalies. Am J Hum Genet. 2011 May 13;88(5):574-85

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory