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Klf9 Gene Detail
Summary
  • Symbol
    Klf9
  • Name
    Kruppel-like factor 9
  • Synonyms
    2310051E17Rik, Bteb1, BTEB-1, Klf9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333856
    NCBI Gene: 16601
  • Gene Overview
    MyGene.info: KLF9
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:23141226-23166911 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 17.90 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    308 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333856
protein coding gene Chr19:23141226-23166911 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024983
protein coding gene Chr19:21269406-21299439 (+)
A/J MGP_AJ_G0024960
protein coding gene Chr19:20106309-20131817 (+)
AKR/J MGP_AKRJ_G0024930
protein coding gene Chr19:20879568-20905372 (+)
BALB/cJ MGP_BALBcJ_G0024959
protein coding gene Chr19:20148590-20174541 (+)
C3H/HeJ MGP_C3HHeJ_G0024717
protein coding gene Chr19:20841101-20866305 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025401
protein coding gene Chr19:21959912-21988627 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022820
protein coding gene Chr19:20292188-20319033 (+)
CAST/EiJ MGP_CASTEiJ_G0024185
protein coding gene Chr19:20548420-20575549 (+)
CBA/J MGP_CBAJ_G0024695
protein coding gene Chr19:22889864-22918835 (+)
DBA/2J MGP_DBA2J_G0024827
protein coding gene Chr19:20124173-20149746 (+)
FVB/NJ MGP_FVBNJ_G0024788
protein coding gene Chr19:19973805-20001094 (+)
LP/J MGP_LPJ_G0024911
protein coding gene Chr19:21221463-21248119 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024815
protein coding gene Chr19:22976121-23017452 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025456
protein coding gene Chr19:20862861-20890005 (+)
PWK/PhJ MGP_PWKPhJ_G0023934
protein coding gene Chr19:19693886-19719540 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023739
protein coding gene Chr19:20085525-20109613 (+)
WSB/EiJ MGP_WSBEiJ_G0024253
protein coding gene Chr19:20887574-20915739 (+)



Homology
more
  • Human Ortholog
    KLF9, Kruppel like factor 9
  • Vertebrate Orthologs
    8
  • Human Ortholog
    KLF9, Kruppel like factor 9
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BTEB, BTEB1
  • Links
    NCBI Gene ID: 687
    neXtProt AC: NX_Q13886
    UniProt: Q13886

  • Chr Location
    9q21.12; chr9:70384597-70414657 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 931
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: KLF9
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice display only mild neurological defects evident by impaired performance in rotarod and contextual fear-conditioning tests.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16601 NCBI Gene Model | MGI Sequence Detail 25686 C57BL/6J ±  kb
    transcript NM_010638 RefSeq | MGI Sequence Detail 3263 C57BL/6  
    polypeptide O35739 UniProt | EBI | MGI Sequence Detail 244 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR036236 Zinc finger C2H2 superfamily
      IPR013087 Zinc finger C2H2-type
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 17
      Primer pair 3

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:1917523, MGI:2147456
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 14
      Gene Ontology 8
      Phenotypes 34
    • Earliest
      J:51610 Imhof A, et al., Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/ egr-related zinc finger repressor. Mol Cell Biol. 1999 Jan;19(1):194-204
    • Latest
      J:261716 McAvoy KM, et al., Modulating Neuronal Competition Dynamics in the Dentate Gyrus to Rejuvenate Aging Memory Circuits. Neuron. 2016 Sep 21;91(6):1356-1373

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory