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Atox1
Gene Detail
Symbol

Name
ID
Atox1
ATX1 (antioxidant protein 1) homolog 1 (yeast)
MGI:1333855
Synonyms
ATX1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
33.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:55446641-55461239 bp, - strand
From VEGA annotation of GRCm38

  14599 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2984  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ATOX1
Gene Tree: Atox1

Human
homologs
ATOX1, antioxidant 1 copper chaperone
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 475
neXtProt AC: NX_O00244

Human Synonyms: ATX1, HAH1

Human Chr (Location): 5q32; chr5:151742822-151758649 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(45) : Gene trapped(42) Targeted(3)
Genomic Mutations involving Atox1 (1)
 
Homozygotes for a targeted null mutation have impaired intracellular copper trafficking and exhibit high postnatal mortality, retarded growth, hypoactivity, loose skin, hypopigmentation, and seizures.
 
Interactions
Atox1 interacts with 19 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cellular copper ion homeostasis, copper ion transmembrane transport, ...
Component cell, intracellular
Function copper chaperone activity, copper-dependent protein binding, ...
External Resources: FuncBase
Expression
cDNA source data(87)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase atox1    NEW 
Molecular
reagents
All nucleic(87) cDNA(87)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000005691 (Evidence)
Ensembl Gene Model ENSMUSG00000018585 (Evidence)
Entrez Gene 11927 (Evidence)
UniGene 217759
DFCI TC1575540
DoTS DT.495095, DT.101725012
NIA Mouse Gene Index U032791
Consensus CDS Project CCDS36158.1
International Mouse Phenotyping Consortium Status Atox1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005691 VEGA Gene Model | MGI Sequence Detail 14599 C57BL/6J ±  kb
transcript OTTMUST00000012664 VEGA | MGI Sequence Detail 541 Not Applicable 
polypeptide OTTMUSP00000005867 VEGA | MGI Sequence Detail 68 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(90 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017969 Heavy-metal-associated, conserved site
InterPro IPR006121 Heavy metal-associated domain, HMA
Protein Ontology PR:000004433 copper transport protein ATOX1
References
(Earliest) J:51199 Nishihara E, et al., Expression of copper trafficking genes in the mouse brain. Neuroreport. 1998 Oct 5;9(14):3259-63
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(40)
Other
accession IDs
MGI:2144096

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory