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Atox1 Gene Detail
Summary
  • Symbol
    Atox1
  • Name
    antioxidant 1 copper chaperone
  • Synonyms
    ATX1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333855
    NCBI Gene: 11927
  • Gene Overview
    MyGene.info: ATOX1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:55446643-55461138 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 33.07 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    90 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333855
protein coding gene Chr11:55446641-55461239 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018331
protein coding gene Chr11:54976996-54993060 (-)
A/J MGP_AJ_G0018300
protein coding gene Chr11:52932127-52946760 (-)
AKR/J MGP_AKRJ_G0018269
protein coding gene Chr11:54656198-54671843 (-)
BALB/cJ MGP_BALBcJ_G0018271
protein coding gene Chr11:53257662-53272430 (-)
C3H/HeJ MGP_C3HHeJ_G0018082
protein coding gene Chr11:54592494-54607074 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018723
protein coding gene Chr11:56644815-56659148 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016373
protein coding gene Chr11:50350200-50364029 (-)
CAST/EiJ MGP_CASTEiJ_G0017647
protein coding gene Chr11:54633826-54648824 (-)
CBA/J MGP_CBAJ_G0018057
protein coding gene Chr11:59338293-59354891 (-)
DBA/2J MGP_DBA2J_G0018166
protein coding gene Chr11:52613998-52628718 (-)
FVB/NJ MGP_FVBNJ_G0018158
protein coding gene Chr11:52280737-52296421 (-)
LP/J MGP_LPJ_G0018241
protein coding gene Chr11:55438713-55455555 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018184
protein coding gene Chr11:60513416-60527964 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018765
protein coding gene Chr11:54678460-54694555 (-)
PWK/PhJ MGP_PWKPhJ_G0017420
protein coding gene Chr11:53189111-53203974 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017215
protein coding gene Chr11:54470640-54484045 (-)
WSB/EiJ MGP_WSBEiJ_G0017695
protein coding gene Chr11:54321373-54337010 (-)



Homology
more
  • Human Ortholog
    ATOX1, antioxidant 1 copper chaperone
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ATOX1, antioxidant 1 copper chaperone
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ATX1, HAH1
  • Links
    NCBI Gene ID: 475
    neXtProt AC: NX_O00244
    UniProt: O00244

  • Chr Location
    5q33.1; chr5:151742822-151758649 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2984
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ATOX1
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation have impaired intracellular copper trafficking and exhibit high postnatal mortality, retarded growth, hypoactivity, loose skin, hypopigmentation, and seizures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 11927 NCBI Gene Model | MGI Sequence Detail 14496 C57BL/6J ±  kb
transcript NM_009720 RefSeq | MGI Sequence Detail 532 C57BL/6  
polypeptide O08997 UniProt | EBI | MGI Sequence Detail 68 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • InterPro Domains
    IPR017969 Heavy-metal-associated, conserved site
    IPR006121 Heavy metal-associated domain, HMA
    IPR036163 Heavy metal-associated domain superfamily
Molecular
Reagents
less
  • All nucleic 88
    cDNA 88

    Microarray probesets 5
Other
Accession IDs
less
MGI:2144096
References
more
  • Summaries
    All 47
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 7
    Phenotypes 14
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:251351 Celauro E, et al., Copper chaperone ATOX1 regulates pluripotency factor OCT4 in preimplantation mouse embryos. Biochem Biophys Res Commun. 2017 Sep 9;491(1):147-153

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory