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Atox1 Gene Detail
Summary
  • Symbol
    Atox1
  • Name
    antioxidant 1 copper chaperone
  • Synonyms
    ATX1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333855
    NCBI Gene: 11927
  • Gene Overview
    MyGene.info: ATOX1
Location & Maps
more
  • Sequence Map
    Chr11:55446641-55461239 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14599 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 33.07 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    ATOX1, antioxidant 1 copper chaperone
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ATOX1, antioxidant 1 copper chaperone
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ATX1, HAH1
  • Links
    NCBI Gene ID: 475
    neXtProt AC: NX_O00244

  • Chr Location
    5q32; chr5:151742822-151758649 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2984
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: ATOX1
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    46
  • Chemically induced (other)
    1
  • Gene trapped
    42
  • Targeted
    3
  • Genomic Mutations
    2 involving Atox1
Homozygotes for a targeted null mutation have impaired intracellular copper trafficking and exhibit high postnatal mortality, retarded growth, hypoactivity, loose skin, hypopigmentation, and seizures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005691 VEGA Gene Model | MGI Sequence Detail 14599 C57BL/6J ±  kb
transcript OTTMUST00000012664 VEGA | MGI Sequence Detail 541 Not Applicable  
polypeptide OTTMUSP00000005867 VEGA | MGI Sequence Detail 68 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    90 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000004433 copper transport protein ATOX1
  • InterPro Domains
    IPR017969 Heavy-metal-associated, conserved site
    IPR006121 Heavy metal-associated domain, HMA
Molecular
Reagents
less
  • All nucleic 87
    cDNA 87

    Microarray probesets 5
Other
Accession IDs
less
MGI:2144096
References
more
  • Summaries
    All 39
    Diseases 1
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:51199 Nishihara E, et al., Expression of copper trafficking genes in the mouse brain. Neuroreport. 1998 Oct 5;9(14):3259-63
  • Latest
    J:217980 Kohno T, et al., Novel role of copper transport protein antioxidant-1 in neointimal formation after vascular injury. Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):805-13

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory