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Rasgrp2 Gene Detail
Summary
  • Symbol
    Rasgrp2
  • Name
    RAS, guanyl releasing protein 2
  • Synonyms
    Caldaggef1, CalDAG-GEFI
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333849
    NCBI Gene: 19395
  • Gene Overview
    MyGene.info: RASGRP2
Location & Maps
more
  • Sequence Map
    Chr19:6399340-6415216 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15877 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 4.58 cM, cytoband A
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    RASGRP2, RAS guanyl releasing protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RASGRP2, RAS guanyl releasing protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CALDAG-GEFI, CDC25L
  • Links
    NCBI Gene ID: 10235
    neXtProt AC: NX_Q7LDG7

  • Chr Location
    11q13; chr11:64726911-64745456 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Rasgrp2 mouse models; 1 with human RASGRP2 associations

Human Disease Mouse Models
       Leukocyte Adhesion Deficiency, Type III; LAD3   OMIM: 612840 View 1 model
       Bleeding Disorder, Platelet-Type, 18; BDPLT18   OMIM: 615888
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    28
  • Gene trapped
    24
  • Targeted
    4
  • Incidental Mutations
    APF , CvDC
Mice homozygous for a knock-out allele do not undergo spontaneous hemorrhaging but exhibit impaired platelet aggregation, resistance to collagen-induced thrombosis, and increased bleeding times after tail transection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018627 VEGA Gene Model | MGI Sequence Detail 15877 C57BL/6J ±  kb
transcript OTTMUST00000060950 VEGA | MGI Sequence Detail 2296 Not Applicable  
polypeptide OTTMUSP00000029800 VEGA | MGI Sequence Detail 608 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    53 from dbSNP Build 142
Protein
Information
less
  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000013759 RAS guanyl-releasing protein 2
  • InterPro Domains
    IPR018247 EF-Hand 1, calcium-binding site
    IPR002048 EF-hand domain
    IPR011992 EF-hand domain pair
    IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
    IPR023578 Ras guanine nucleotide exchange factor domain
    IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
    IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
Molecular
Reagents
less
  • All nucleic 11
    cDNA 7
    Primer pair 3
    Other 1

    Microarray probesets 6
References
more
  • Summaries
    All 50
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 3
    Phenotypes 19
  • Earliest
    J:52725 Kedra D, et al., The germinal center kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13. Hum Genet. 1997 Oct;100(5-6):611-9
  • Latest
    J:230666 Freeman SA, et al., Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis. Cell. 2016 Jan 14;164(1-2):128-40

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory