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Rasgrp2
Gene Detail
Symbol

Name
ID
Rasgrp2
RAS, guanyl releasing protein 2
MGI:1333849
Synonyms
Caldaggef1, CalDAG-GEFI
Feature Type
protein coding gene
Genetic Map
Chromosome 19
4.58 cM, cytoband A
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:6399340-6415216 bp, + strand
From VEGA annotation of GRCm38

  15877 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4250  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RASGRP2
Gene Tree: Rasgrp2

Human
homologs
RASGRP2, RAS guanyl releasing protein 2 (calcium and DAG-regulated)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10235
neXtProt AC: NX_Q7LDG7

Human Synonyms: CALDAG-GEFI, CDC25L

Human Chr (Location): 11q13; chr11:64726911-64745456 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human RASGRP2

Mutations,
alleles, and
phenotypes
All mutations/alleles(28) : Gene trapped(24) Targeted(4)
Incidental mutations (data from APF , CvDC )
 
Mice homozygous for a knock-out allele do not undergo spontaneous hemorrhaging but exhibit impaired platelet aggregation, resistance to collagen-induced thrombosis, and increased bleeding times after tail transection.
 
Interactions
Rasgrp2 interacts with 303 markers (Mir7-2, Mir7b, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cellular response to calcium ion, intracellular signal transduction, ...
Component cell junction, cell projection, ...
Function calcium ion binding, guanyl-nucleotide exchange factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (3)    Tissues (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 3
cDNA source data(7)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(7) Primer pair(3) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000018627 (Evidence)
Ensembl Gene Model ENSMUSG00000032946 (Evidence)
Entrez Gene 19395 (Evidence)
DoTS DT.91416047, DT.91311324, DT.487131, DT.102552472, DT.94125337
NIA Mouse Gene Index U038687
Consensus CDS Project CCDS37898.1
International Mouse Phenotyping Consortium Status Rasgrp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018627 VEGA Gene Model | MGI Sequence Detail 15877 C57BL/6J ±  kb
transcript OTTMUST00000060950 VEGA | MGI Sequence Detail 2296 Not Applicable 
polypeptide OTTMUSP00000029800 VEGA | MGI Sequence Detail 608 Not Applicable 

For the selected sequences
All sequences(135) RefSeq(28) UniProt(9)
Polymorphisms
SNPs within 2kb(53 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR001895 Guanine-nucleotide dissociation stimulator CDC25
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR023578 Ras guanine nucleotide exchange factor, domain
InterPro IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
Protein Ontology PR:000013759 RAS guanyl-releasing protein 2
References
(Earliest) J:52725 Kedra D, et al., The germinal center kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13. Hum Genet. 1997 Oct;100(5-6):611-9
(Latest) J:210743 Stefanini L, et al., A talin mutant that impairs talin-integrin binding in platelets decelerates alphaIIbbeta3 activation without pathological bleeding. Blood. 2014 Apr 24;123(17):2722-31
All references(48)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory