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Slc31a1 Gene Detail
Summary
  • Symbol
    Slc31a1
  • Name
    solute carrier family 31, member 1
  • Synonyms
    4930445G01Rik, Ctr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333843
    NCBI Gene: 20529
  • Gene Overview
    MyGene.info: SLC31A1
Location & Maps
more
  • Sequence Map
    Chr4:62360727-62391769 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31043 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SLC31A1, solute carrier family 31 member 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC31A1, solute carrier family 31 member 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    COPT1, CTR1
  • Links
    NCBI Gene ID: 1317
    neXtProt AC: NX_O15431

  • Chr Location
    9q32; chr9:113221528-113264492 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 3 alleles in 3 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    73
  • Gene trapped
    67
  • Targeted
    6
  • Incidental Mutations
Mice homozygous for a null allele exhibit embryonic lethality during organogenesis associated with abnormal embryogenesis. Mice heterozygous for a null allele exhibit decreased copper levels in the blood and several organs.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001231 VEGA Gene Model | MGI Sequence Detail 31043 C57BL/6J ±  kb
transcript OTTMUST00000002460 VEGA | MGI Sequence Detail 3718 Not Applicable  
polypeptide OTTMUSP00000001213 VEGA | MGI Sequence Detail 196 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    134 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000015083 high affinity copper uptake protein 1
  • InterPro Domains
    IPR007274 Ctr copper transporter
Molecular
Reagents
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  • All nucleic 21
    Genomic 1
    cDNA 18
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
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MGI:1925416, MGI:2140357, MGI:2140433
References
more
  • Summaries
    All 48
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 17
  • Earliest
    J:51199 Nishihara E, et al., Expression of copper trafficking genes in the mouse brain. Neuroreport. 1998 Oct 5;9(14):3259-63
  • Latest
    J:210437 Brady DC, et al., Copper is required for oncogenic BRAF signalling and tumorigenesis. Nature. 2014 May 22;509(7501):492-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory