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Slc31a1
Gene Detail
 Symbol
Name
ID
Slc31a1
solute carrier family 31, member 1
MGI:1333843
Synonyms 4930445G01Rik, Ctr1
Feature Type protein coding gene
Genetic Map
Chromosome 4
33.11 cM, cytoband C1-C2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:62360727-62391769 bp, + strand
From VEGA annotation of GRCm38

  31043 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1399  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Slc31a1

Human
homologs
Human Homolog SLC31A1, solute carrier family 31 (copper transporter), member 1
NCBI Gene ID 1317
neXtProt AC  NX_O15431
Human Synonyms  COPT1, CTR1
Human Chr (Location)  9q32; chr9:113221528-113264492 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(72) : Gene trapped(67) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit embryonic lethality during organogenesis associated with abnormal embryogenesis. Mice heterozygous for a null allele exhibit decreased copper levels in the blood and several organs.
 
Interactions
Slc31a1 interacts with 347 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cellular copper ion homeostasis, cellular response to cisplatin, ...
Component cell, cytoplasm, ...
Function copper ion transmembrane transporter activity, copper uptake transmembrane transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (212)    Tissues (110)    Images (32)
Theiler Stages: 2, 3, 22, 23
Assay TypeResults
RNA in situ 176
RT-PCR 36
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(1) cDNA(17) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000001231 (Evidence)
Ensembl Gene ModelENSMUSG00000066150 (Evidence)
Entrez Gene20529 (Evidence)
NIA Mouse Gene IndexU004390
Consensus CDS ProjectCCDS18237.1
International Mouse Knockout Project StatusSlc31a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001231 VEGA Gene Model | MGI Sequence Detail 31043 C57BL/6J ±  kb
transcript OTTMUST00000002460 VEGA | MGI Sequence Detail 3718 Not Applicable 
polypeptide OTTMUSP00000001213 VEGA | MGI Sequence Detail 196 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(134 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007274 Ctr copper transporter
Protein Ontology PR:000015083 high affinity copper uptake protein 1
References (Earliest) J:51199 Nishihara E, et al., Expression of copper trafficking genes in the mouse brain. Neuroreport. 1998 Oct 5;9(14):3259-63
(Latest) J:210437 Brady DC, et al., Copper is required for oncogenic BRAF signalling and tumorigenesis. Nature. 2014 May 22;509(7501):492-6
All references(49)
Other
accession IDs
MGI:1925416, MGI:2140357, MGI:2140433

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory