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Cbfa2t2
Gene Detail
 Symbol
Name
ID
Cbfa2t2
core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human)
MGI:1333833
Synonyms C330013D05Rik, Cbfa2t2h, MTGR1
Feature Type protein coding gene
Genetic Map
Chromosome 2
76.62 cM, cytoband C3.2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:154436481-154539356 bp, + strand
From VEGA annotation of GRCm38

  102876 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3733  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Cbfa2t2

Human
homologs
Human Homolog CBFA2T2, core-binding factor, runt domain, alpha subunit 2; translocated to, 2
NCBI Gene ID 9139
neXtProt AC  NX_O43439
Human Synonyms  EHT, MTGR1, p85, ZMYND3
Human Chr (Location)  20q11; chr20:33490122-33650031 (+)  GRCh38
Alleles
and
phenotypes
All alleles(264) : Gene trapped(261) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null allele display reduced body size, decreased numbers of intestinal goblet, Paneth, and enteroendocrine cells, small intestinal inflammation, and strain background dependent partial postnatal lethality.
 
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process epithelial cell differentiation, negative regulation of transcription, DNA-templated, ...
Component nucleus
Function metal ion binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (240)    Tissues (124)    Images (35)
Theiler Stages: 5, 22, 23
Assay TypeResults
RNA in situ 240
cDNA source data(97)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(101) Genomic(2) cDNA(98) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000015790 (Evidence)
Ensembl Gene ModelENSMUSG00000038533 (Evidence)
Entrez Gene12396 (Evidence)
UniGene29914
DFCITC1582666, TC1601128, TC1620203
DoTSDT.101305679, DT.110714133, DT.91571796, DT.94127596
NIA Mouse Gene IndexU042388
Consensus CDS ProjectCCDS16932.1, CCDS50764.1
International Mouse Knockout Project StatusCbfa2t2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015790 VEGA Gene Model | MGI Sequence Detail 102876 C57BL/6J ±  kb
transcript OTTMUST00000037541 VEGA | MGI Sequence Detail 6069 Not Applicable 
polypeptide OTTMUSP00000016821 VEGA | MGI Sequence Detail 594 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(12) UniProt(5)
Polymorphisms SNPs within 2kb(649 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013289 Eight-Twenty-One
InterPro IPR013291 Myeloid transforming gene-related protein-1 (MTGR1)
InterPro IPR014896 NHR2-like
InterPro IPR003894 TAFH/NHR1
InterPro IPR002893 Zinc finger, MYND-type
Protein Ontology PR:000005067 protein CBFA2T2
References (Earliest) J:50334 Calabi F, et al., CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family. Genomics. 1998 Sep 15;52(3):332-41
(Latest) J:195746 Bhattacharya A, et al., Upstream distal regulatory elements contact the Lmo2 promoter in mouse erythroid cells. PLoS One. 2012;7(12):e52880
All references(45)
Other
accession IDs
MGI:2445049

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory