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Cbfa2t2
Gene Detail
Symbol

Name
ID
Cbfa2t2
core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human)
MGI:1333833
Synonyms
C330013D05Rik, Cbfa2t2h, MTGR1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
76.62 cM, cytoband C3.2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:154436481-154539356 bp, + strand
From VEGA annotation of GRCm38

  102876 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3733  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: CBFA2T2
Gene Tree: Cbfa2t2

Human
homologs
CBFA2T2, core-binding factor, runt domain, alpha subunit 2; translocated to, 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 9139
neXtProt AC: NX_O43439

Human Synonyms: EHT, MTGR1, p85, ZMYND3

Human Chr (Location): 20q11; chr20:33490122-33650031 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(264) : Gene trapped(261) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a targeted null allele display reduced body size, decreased numbers of intestinal goblet, Paneth, and enteroendocrine cells, small intestinal inflammation, and strain background dependent partial postnatal lethality.
 
Interactions
Cbfa2t2 interacts with 381 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process epithelial cell differentiation, negative regulation of nucleic acid-templated transcription, ...
Component nucleus
Function metal ion binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (277)    Tissues (146)    Images (53)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 277
cDNA source data(97)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA CBFA2T2 ; Xenbase cbfa2t2    NEW 
Molecular
reagents
All nucleic(102) Genomic(2) cDNA(98) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000015790 (Evidence)
Ensembl Gene Model ENSMUSG00000038533 (Evidence)
Entrez Gene 12396 (Evidence)
UniGene 29914
DFCI TC1620203, TC1601128, TC1582666
DoTS DT.101305679, DT.94127596, DT.91571796, DT.110714133
NIA Mouse Gene Index U042388
Consensus CDS Project CCDS16932.1, CCDS50764.1
International Mouse Phenotyping Consortium Status Cbfa2t2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015790 VEGA Gene Model | MGI Sequence Detail 102876 C57BL/6J ±  kb
transcript OTTMUST00000037541 VEGA | MGI Sequence Detail 6069 Not Applicable 
polypeptide OTTMUSP00000016821 VEGA | MGI Sequence Detail 594 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(14) UniProt(5)
Polymorphisms
SNPs within 2kb(649 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013289 Eight-Twenty-One
InterPro IPR013291 Myeloid transforming gene-related protein-1 (MTGR1)
InterPro IPR014896 NHR2-like
InterPro IPR003894 TAFH/NHR1
InterPro IPR002893 Zinc finger, MYND-type
Protein Ontology PR:000005067 protein CBFA2T2
References
(Earliest) J:50334 Calabi F, et al., CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family. Genomics. 1998 Sep 15;52(3):332-41
(Latest) J:219649 Parang B, et al., The transcriptional corepressor MTGR1 regulates intestinal secretory lineage allocation. FASEB J. 2015 Mar;29(3):786-95
All references(45)
Other
accession IDs
MGI:2445049

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory