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Cbfa2t2 Gene Detail
Summary
  • Symbol
    Cbfa2t2
  • Name
    core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human)
  • Synonyms
    C330013D05Rik, Cbfa2t2h, MTGR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333833
    NCBI Gene: 12396
  • Gene Overview
    MyGene.info: CBFA2T2
Location & Maps
more
  • Sequence Map
    Chr2:154436481-154539356 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      102876 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 76.62 cM, cytoband C3.2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CBFA2T2, CBFA2/RUNX1 translocation partner 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CBFA2T2, CBFA2/RUNX1 translocation partner 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EHT, MTGR1, p85, ZMYND3
  • Links
    NCBI Gene ID: 9139
    neXtProt AC: NX_O43439

  • Chr Location
    20q11; chr20:33490122-33650031 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null allele display reduced body size, decreased numbers of intestinal goblet, Paneth, and enteroendocrine cells, small intestinal inflammation, and strain background dependent partial postnatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015790 VEGA Gene Model | MGI Sequence Detail 102876 C57BL/6J ±  kb
transcript OTTMUST00000037541 VEGA | MGI Sequence Detail 6069 Not Applicable  
polypeptide OTTMUSP00000016821 VEGA | MGI Sequence Detail 594 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    642 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 102
    Genomic 2
    cDNA 98
    Primer pair 1
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGI:2445049
References
more
  • Summaries
    All 42
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:50334 Calabi F, et al., CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family. Genomics. 1998 Sep 15;52(3):332-41
  • Latest
    J:219649 Parang B, et al., The transcriptional corepressor MTGR1 regulates intestinal secretory lineage allocation. FASEB J. 2015 Mar;29(3):786-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory