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Itln1 Gene Detail
Summary
  • Symbol
    Itln1
  • Name
    intelectin 1 (galactofuranose binding)
  • Synonyms
    IntL, Itln2, Itlna, mLfR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333831
    NCBI Gene: 16429
Location & Maps
more
  • Sequence Map
    Chr1:171518122-171535294 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17173 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 79.49 cM, cytoband H2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ITLN1, intelectin 1
  • Vertebrate Orthologs
    19
  • Human Ortholog
    ITLN1, intelectin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hIntL, HL1, HL-1, INTL, ITLN, LFR, omentin
  • Links
    NCBI Gene ID: 55600
    neXtProt AC: NX_Q8WWA0

  • Chr Location
    1q21.3; chr1:160876540-160885170 (-)  GRCh38.p2

  • Human Ortholog
    ITLN2, intelectin 2
    Orthology source: HGNC
  • Synonyms
    HL2, HL-2
  • Links
    NCBI Gene ID: 142683
    neXtProt AC: NX_Q8WWU7

  • Chr Location
    1q22-q23; chr1:160945020-160957378 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    2
  • Targeted
    3
  • Genomic Mutations
    2 involving Itln1
  • Incidental Mutations
Phenotypic analysis of mice homozygous for a targeted null allele indicates this mutation has no notable phenotype in any parameter tested.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036496 VEGA Gene Model | MGI Sequence Detail 17173 C57BL/6J ±  kb
transcript OTTMUST00000093565 VEGA | MGI Sequence Detail 1141 Not Applicable  
polypeptide OTTMUSP00000051939 VEGA | MGI Sequence Detail 313 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    291 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000033904 intelectin-1a
  • InterPro Domains
    IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
    IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
Molecular
Reagents
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  • All nucleic 6
    Genomic 2
    cDNA 4

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:50538 Komiya T, et al., Cloning of the novel gene intelectin, which is expressed in intestinal paneth cells in mice. Biochem Biophys Res Commun. 1998 Oct 29;251(3):759-62
  • Latest
    J:194542 Ghai R, et al., Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E643-52

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory