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Dgat1
Gene Detail
 Symbol
Name
ID
Dgat1
diacylglycerol O-acyltransferase 1
MGI:1333825
Synonyms D15Ertd23e
Feature Type protein coding gene
Genetic Map
Chromosome 15
35.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr15:76502015-76511951 bp, - strand
From VEGA annotation of GRCm38

  9937 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7688  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: sterol O-acyltransferase, ACAT/DAG/ARE types
Gene Tree: Dgat1

Human
homologs
Human Homolog DGAT1, diacylglycerol O-acyltransferase 1
NCBI Gene ID 8694
neXtProt AC  NX_O75907
Human Synonyms  ARAT, ARGP1, DGAT, DIAR7
Human Chr (Location)  8q24.3; chr8:144314583-144326919 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human DGAT1
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Radiation induced(1) Targeted(6)
Genomic Mutations involving Dgat1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants are able to synthesize triglycerides, but are lean, resistant to diet-induced obesity and show increased activity and energy expenditure; lactation is defective in females.
 
Phenotype Images(5)
Interactions
Dgat1 interacts with 38 markers (Mir137, Mir185, Mir214, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process diacylglycerol metabolic process, fatty acid homeostasis, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function 2-acylglycerol O-acyltransferase activity, diacylglycerol binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (106)    Tissues (104)    Images (2)
Theiler Stages: 15, 21, 22, 26, 27, 28
Assay TypeResults
RNA in situ 94
RT-PCR 12
cDNA source data(63)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(66) cDNA(63) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000034893 (Evidence)
Ensembl Gene ModelENSMUSG00000022555 (Evidence)
Entrez Gene13350 (Evidence)
UniGene22633
DFCITC1579105, TC1600976, TC1640666, TC1665272
NIA Mouse Gene IndexU036345
EC2.3.1.20, 2.3.1.76
Consensus CDS ProjectCCDS27573.1
International Mouse Knockout Project StatusDgat1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034893 VEGA Gene Model | MGI Sequence Detail 9937 C57BL/6J ±  kb
transcript OTTMUST00000088696 VEGA | MGI Sequence Detail 1888 Not Applicable 
polypeptide OTTMUSP00000048375 VEGA | MGI Sequence Detail 498 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(5) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(21 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027251 Diacylglycerol O-acyltransferase 1
InterPro IPR004299 Membrane bound O-acyl transferase, MBOAT
InterPro IPR014371 Sterol O-acyltransferase, ACAT/DAG/ARE types
Protein Ontology PR:000006432 diacylglycerol O-acyltransferase 1
References (Earliest) J:44983 Cases S, et al., Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13018-23
(Latest) J:204194 Wongsiriroj N, et al., Genetic dissection of retinoid esterification and accumulation in the liver and adipose tissue. J Lipid Res. 2014 Jan;55(1):104-14
All references(80)
Other
accession IDs
MGI:1098564, MGI:2139452

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory