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S1pr4
Gene Detail
 Symbol
Name
ID
S1pr4
sphingosine-1-phosphate receptor 4
MGI:1333809
Synonyms Edg6, lpC1, S1P4
Feature Type protein coding gene
Genetic Map
Chromosome 10
39.72 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:81497745-81500132 bp, - strand
From Ensembl annotation of GRCm38

  2388 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2799  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: LPAR1/S1PR1-like lysophospholipid receptor
Gene Tree: S1pr4

Human
homologs
Human Homolog S1PR4, sphingosine-1-phosphate receptor 4
NCBI Gene ID 8698
neXtProt AC  NX_O95977
Human Synonyms  EDG6, LPC1, S1P4, SLP4
Human Chr (Location)  19p13.3; chr19:3178738-3180332 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in mid-gestation embryonic lethality. Heterozygotes exhibit decreased prepulse inhibition.
 
Interactions
S1pr4 interacts with 77 markers (Mir101a, Mir101b, Mir134, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process adenylate cyclase-activating G-protein coupled receptor signaling pathway, G-protein coupled receptor signaling pathway, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function G-protein coupled receptor activity, signal transducer activity, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (167)    Tissues (99)    Images (25)
Theiler Stages: 11, 13, 15, 17, 19, 20, 23, 28
Assay TypeResults
RNA in situ 78
In situ reporter (knock in) 38
RT-PCR 51
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(13) Primer pair(4)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000044199 (Evidence)
Entrez Gene13611 (Evidence)
UniGene33065
DoTSDT.527512, DT.97339181
NIA Mouse Gene IndexU191278
Consensus CDS ProjectCCDS24059.1
International Mouse Knockout Project StatusS1pr4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000044199 Ensembl Gene Model | MGI Sequence Detail 2388 C57BL/6J ±  kb
transcript ENSMUST00000053646 Ensembl | MGI Sequence Detail 2388 Not Applicable 
polypeptide ENSMUSP00000050412 Ensembl | MGI Sequence Detail 386 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004064 EDG-6 sphingosine 1-phosphate receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR004061 Sphingosine 1-phosphate receptor
Protein Ontology PR:000001709 sphingosine 1-phosphate receptor 4
References (Earliest) J:50535 Graler MH, et al., EDG6, a novel G-protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue. Genomics. 1998 Oct 15;53(2):164-9
(Latest) J:203881 Cencetti F, et al., TGFbeta1 evokes myoblast apoptotic response via a novel signaling pathway involving S1P4 transactivation upstream of Rho-kinase-2 activation. FASEB J. 2013 Nov;27(11):4532-46
All references(47)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory