S1pr4
Gene Detail

Symbol Name ID

S1pr4 sphingosine-1-phosphate receptor 4 MGI:1333809

Synonyms

Edg6, lpC1, S1P4

Feature Type

protein coding gene

Genetic Map

Chromosome 10

39.72 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr10:81497745-81500132 bp, - strand From Ensembl annotation of GRCm38   2388 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human S1pr4 ± 2 cM)

Protein SuperFamily: LPAR1/S1PR1-like lysophospholipid receptor
Gene Tree: S1pr4

Human ortholog

S1PR4 sphingosine-1-phosphate receptor 4 NCBI Gene ID 8698
Human Synonyms: EDG6, LPC1, S1P4, SLP4
Human Chr19:3178736-3180330 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(6) : Targeted(5) Gene trapped(1)
 

Homozygous mutation of this gene results in mid-gestation embryonic lethality. Heterozygotes exhibit decreased prepulse inhibition.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	adenylate cyclase-activating G-protein coupled receptor signaling pathway, G-protein coupled receptor signaling pathway, ...
Component	integral to membrane, integral to plasma membrane, ...
Function	G-protein coupled receptor activity, signal transducer activity, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (155)    Tissues (96)    Images (18)
Theiler Stages: 11, 13, 15, 17, 19, 20, 23, 28

Assay Type	Results
RNA in situ	66
In situ reporter (knock in)	38
RT-PCR	51

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(12) Primer pair(3)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000044199 (Evidence)
Entrez Gene	13611 (Evidence)
UniGene	33065
DoTS	DT.527512, DT.97339181
NIA Mouse Gene Index	U191278
Consensus CDS Project	CCDS24059.1
International Mouse Knockout Project Status	S1pr4

Sequences

Length	Strain/Species
genomic	ENSMUSG00000044199	Ensembl Gene Model | MGI Sequence Detail	2388	C57BL/6J
transcript	ENSMUST00000053646	Ensembl | MGI Sequence Detail	2388	Not Applicable
polypeptide	ENSMUSP00000050412	Ensembl | MGI Sequence Detail	386	Not Applicable

All sequences(16) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(22 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004064	EDG-6 sphingosine 1-phosphate receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR004061	Sphingosine 1-phosphate receptor
Protein Ontology	PR:000001709	sphingosine 1-phosphate receptor 4

References

(Earliest) J:50535 Graler MH, et al., EDG6, a novel G-protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue. Genomics. 1998 Oct 15;53(2):164-9
(Latest) J:180663 Calise S, et al., Sphingosine 1-phosphate stimulates proliferation and migration of satellite cells Role of S1P receptors. Biochim Biophys Acta. 2012 Feb;1823(2):439-50
All references(46)