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Rad17
Gene Detail
Symbol

Name
ID
Rad17
RAD17 homolog (S. pombe)
MGI:1333807
Synonyms
9430035O09Rik, MmRad24
Feature Type
protein coding gene
Genetic Map
Chromosome 13
53.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:100617165-100651059 bp, - strand
From Ensembl annotation of GRCm38

  33895 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32117  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Rad17

Human
homologs
Human Homolog RAD17, RAD17 homolog (S. pombe)
NCBI Gene ID 5884
neXtProt AC  NX_O75943
Human Synonyms  CCYC, HRAD17, R24L, RAD17SP, RAD24
Human Chr (Location)  5q13; chr5:69369297-69414801 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(12) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display embryonic lethality with incomplete somite formation, abnormal bracnchial arch, liver, and heart morphology, abnormal neural tube development, and multiple hemorrhages.
 
Interactions
Rad17 interacts with 126 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cell cycle, cellular response to DNA damage stimulus, ...
Component chromosome, telomeric region, nucleoplasm, ...
Function ATP binding, DNA clamp loader activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (6)    Tissues (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 3
RT-PCR 3
cDNA source data(66)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(70) cDNA(67) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000021635 (Evidence)
Entrez Gene19356 (Evidence)
UniGene248489
DFCITC1577917, TC1683667
NIA Mouse Gene IndexU035112
Consensus CDS ProjectCCDS26733.1
International Mouse Knockout Project StatusRad17
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021635 Ensembl Gene Model | MGI Sequence Detail 33895 C57BL/6J ±  kb
transcript ENSMUST00000022136 Ensembl | MGI Sequence Detail 2846 Not Applicable 
polypeptide ENSMUSP00000022136 Ensembl | MGI Sequence Detail 688 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(57 from dbSNP Build 137)    SNPs within 2kb including multiple locations(59)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR004582 Checkpoint protein Rad17/Rad24
InterPro IPR018324 Checkpoint protein Rad24, fungi/metazoa
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000013665 cell cycle checkpoint protein RAD17
References
(Earliest) J:49975 Udell CM, et al., HRAD1 and MRAD1 encode mammalian homologues of the fission yeast rad1(+) cell cycle checkpoint control gene. Nucleic Acids Res. 1998 Sep 1;26(17):3971-6
(Latest) J:184521 Koss M, et al., Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
All references(37)
Other
accession IDs
MGI:2441744

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory