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Rad17 Gene Detail
Summary
  • Symbol
    Rad17
  • Name
    RAD17 checkpoint clamp loader component
  • Synonyms
    9430035O09Rik, MmRad24
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333807
    NCBI Gene: 19356
  • Gene Overview
    MyGene.info: RAD17
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:100617164-100651051 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 53.23 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    56 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333807
protein coding gene Chr13:100617164-100651061 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020888
protein coding gene Chr13:102538015-102578317 (-)
A/J MGP_AJ_G0020840
protein coding gene Chr13:98557196-98591331 (-)
AKR/J MGP_AKRJ_G0020815
protein coding gene Chr13:101583157-101617391 (-)
BALB/cJ MGP_BALBcJ_G0020839
protein coding gene Chr13:99284933-99319111 (-)
C3H/HeJ MGP_C3HHeJ_G0020629
protein coding gene Chr13:101289215-101323820 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021273
protein coding gene Chr13:105595393-105633656 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018844
protein coding gene Chr13:94384147-94416294 (-)
CAST/EiJ MGP_CASTEiJ_G0020148
protein coding gene Chr13:100754564-100790629 (-)
CBA/J MGP_CBAJ_G0020590
protein coding gene Chr13:109756499-109796378 (-)
DBA/2J MGP_DBA2J_G0020715
protein coding gene Chr13:98338718-98372501 (-)
FVB/NJ MGP_FVBNJ_G0020696
protein coding gene Chr13:97076896-97114165 (-)
LP/J MGP_LPJ_G0020789
protein coding gene Chr13:102555976-102593113 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020725
protein coding gene Chr13:110006640-110042299 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021313
protein coding gene Chr13:101042618-101077968 (-)
PWK/PhJ MGP_PWKPhJ_G0019901
protein coding gene Chr13:97053911-97089517 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019723
protein coding gene Chr13:97269782-97304416 (-)
WSB/EiJ MGP_WSBEiJ_G0020205
protein coding gene Chr13:101499339-101535942 (-)



Homology
more
  • Human Ortholog
    RAD17, RAD17 checkpoint clamp loader component
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RAD17, RAD17 checkpoint clamp loader component
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CCYC, HRAD17, R24L, RAD17SP, RAD24
  • Links
    NCBI Gene ID: 5884
    neXtProt AC: NX_O75943
    UniProt: O75943

  • Chr Location
    5q13.2; chr5:69369297-69414801 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32117
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RAD17
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality with incomplete somite formation, abnormal bracnchial arch, liver, and heart morphology, abnormal neural tube development, and multiple hemorrhages.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021635 Ensembl Gene Model | MGI Sequence Detail 33888 C57BL/6J ±  kb
    transcript ENSMUST00000022136 Ensembl | MGI Sequence Detail 2839 Not Applicable  
    polypeptide ENSMUSP00000022136 Ensembl | MGI Sequence Detail 688 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 71
      cDNA 68
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2441744
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:49975 Udell CM, et al., HRAD1 and MRAD1 encode mammalian homologues of the fission yeast rad1(+) cell cycle checkpoint control gene. Nucleic Acids Res. 1998 Sep 1;26(17):3971-6
    • Latest
      J:184521 Koss M, et al., Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory