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Rad17 Gene Detail
Summary
  • Symbol
    Rad17
  • Name
    RAD17 checkpoint clamp loader component
  • Synonyms
    9430035O09Rik, MmRad24
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333807
    NCBI Gene: 19356
  • Gene Overview
    MyGene.info: RAD17
Location & Maps
more
  • Sequence Map
    Chr13:100617165-100651059 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      33895 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    RAD17, RAD17 checkpoint clamp loader component
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RAD17, RAD17 checkpoint clamp loader component
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CCYC, HRAD17, R24L, RAD17SP, RAD24
  • Links
    NCBI Gene ID: 5884
    neXtProt AC: NX_O75943

  • Chr Location
    5q13; chr5:69369297-69414801 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 32117
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: RAD17
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Gene trapped
    12
  • Targeted
    5
  • Incidental Mutations
Homozygous null mice display embryonic lethality with incomplete somite formation, abnormal bracnchial arch, liver, and heart morphology, abnormal neural tube development, and multiple hemorrhages.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021635 Ensembl Gene Model | MGI Sequence Detail 33895 C57BL/6J ±  kb
transcript ENSMUST00000022136 Ensembl | MGI Sequence Detail 2846 Not Applicable  
polypeptide ENSMUSP00000022136 Ensembl | MGI Sequence Detail 688 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    56 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000013665 cell cycle checkpoint protein RAD17
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR004582 Checkpoint protein Rad17/Rad24
    IPR018324 Checkpoint protein Rad17/Rad24, fungi/metazoa
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 70
    cDNA 67
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
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MGI:2441744
References
more
  • Summaries
    All 34
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:49975 Udell CM, et al., HRAD1 and MRAD1 encode mammalian homologues of the fission yeast rad1(+) cell cycle checkpoint control gene. Nucleic Acids Res. 1998 Sep 1;26(17):3971-6
  • Latest
    J:184521 Koss M, et al., Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory