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Srsf10 Gene Detail
Summary
  • Symbol
    Srsf10
  • Name
    serine/arginine-rich splicing factor 10
  • Synonyms
    Fusip1, FUSIP2, Nssr, NSSR1, NSSR2, Sfrs13a, SRrp40, Srsf13a, TASR1, TASR2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333805
    NCBI Gene: 14105
  • Gene Overview
    MyGene.info: SRSF10
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:135855747-135869908 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14162 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 68.01 cM, cytoband D3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SRSF10, serine and arginine rich splicing factor 10
  • Vertebrate Orthologs
    6
  • Human Ortholog
    SRSF10, serine and arginine rich splicing factor 10
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FUSIP1, FUSIP2, NSSR, PPP1R149, SFRS13, SFRS13A, SRp38, SRrp40, TASR, TASR1, TASR2
  • Links
    NCBI Gene ID: 10772
    neXtProt AC: NX_O75494
    UniProt: O75494

  • Chr Location
    1p36.11; chr1:23964347-23980927 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit fetal and neonatal lethality associated with edema and cardiac defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000009794 VEGA Gene Model | MGI Sequence Detail 14162 C57BL/6J ±  kb
    transcript OTTMUST00000022692 VEGA | MGI Sequence Detail 3058 Not Applicable  
    polypeptide OTTMUSP00000010356 VEGA | MGI Sequence Detail 262 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      88 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 26
      Primer pair 2

      Microarray probesets 8
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 8
      Gene Ontology 5
      Phenotypes 14
    • Earliest
      J:51309 Yang L, et al., Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing. J Biol Chem. 1998 Oct 23;273(43):27761-4
    • Latest
      J:228946 Wei N, et al., SRSF10 Plays a Role in Myoblast Differentiation and Glucose Production via Regulation of Alternative Splicing. Cell Rep. 2015 Nov 24;13(8):1647-57

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory