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Top3b Gene Detail
Summary
  • Symbol
    Top3b
  • Name
    topoisomerase (DNA) III beta
  • Synonyms
    Topo III beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333803
    NCBI Gene: 21976
  • Gene Overview
    MyGene.info: TOP3B
Location & Maps
more
  • Sequence Map
    Chr16:16870736-16892990 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22255 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TOP3B, topoisomerase (DNA) III beta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TOP3B, topoisomerase (DNA) III beta
    Orthology source: HGNC, HomoloGene
  • Synonyms
    TOP3B1
  • Links
    NCBI Gene ID: 8940
    neXtProt AC: NX_O95985

  • Chr Location
    22q11.22; chr22:21957025-21982843 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2923
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: TOP3B
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygous null mice develop to maturity but die prematurely showing enlargement of lymphatic organs and glomerulonephritis. Intercrossing of mutant mice progressively results in infertility that is correlated to increased aneuploidy in germ cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027460 VEGA Gene Model | MGI Sequence Detail 22255 C57BL/6J ±  kb
transcript OTTMUST00000067954 VEGA | MGI Sequence Detail 3073 Not Applicable  
polypeptide OTTMUSP00000034277 VEGA | MGI Sequence Detail 862 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    115 from dbSNP Build 142
Protein
Information
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  • UniProt
    11 Sequences
  • Protein Ontology
    PR:000016547 DNA topoisomerase 3-beta-1
  • EC
  • InterPro Domains
    IPR000380 DNA topoisomerase, type IA
    IPR023406 DNA topoisomerase, type IA, active site
    IPR013497 DNA topoisomerase, type IA, central
    IPR013824 DNA topoisomerase, type IA, central region, subdomain 1
    IPR013825 DNA topoisomerase, type IA, central region, subdomain 2
    IPR013826 DNA topoisomerase, type IA, central region, subdomain 3
    IPR023405 DNA topoisomerase, type IA, core domain
    IPR003602 DNA topoisomerase, type IA, DNA-binding domain
    IPR003601 DNA topoisomerase, type IA, domain 2
    IPR011031 Multihaem cytochrome
    IPR006171 Toprim domain
Molecular
Reagents
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  • All nucleic 92
    cDNA 91
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:50529 Seki T, et al., Cloning of cDNA encoding a novel mouse DNA topoisomerase III (Topo IIIbeta) possessing negatively supercoiled DNA relaxing activity, whose message is highly expressed in the testis. J Biol Chem. 1998 Oct 30;273(44):28553-6
  • Latest
    J:203883 Xu D, et al., Top3beta is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation. Nat Neurosci. 2013 Sep;16(9):1238-47

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory