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Klf12 Gene Detail
Summary
  • Symbol
    Klf12
  • Name
    Kruppel-like factor 12
  • Synonyms
    2700063E05Rik, AP-2rep, B130052C06Rik, D530033K05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333796
    NCBI Gene: 16597
  • Gene Overview
    MyGene.info: KLF12
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:99870632-100284679 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 50.90 cM, cytoband E2.2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2809 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333796
protein coding gene Chr14:99866181-100284775 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021619
protein coding gene Chr14:96211601-96496081 (-)
A/J MGP_AJ_G0021577
protein coding gene Chr14:93118133-93395273 (-)
AKR/J MGP_AKRJ_G0021553
protein coding gene Chr14:95859884-96148141 (-)
BALB/cJ MGP_BALBcJ_G0021583
protein coding gene Chr14:93454658-93732921 (-)
C3H/HeJ MGP_C3HHeJ_G0021361
protein coding gene Chr14:95764753-96049124 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022023
protein coding gene Chr14:100129117-100426924 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019563
protein coding gene Chr14:90163162-90426037 (-)
CAST/EiJ MGP_CASTEiJ_G0020878
protein coding gene Chr14:93066359-93346092 (-)
CBA/J MGP_CBAJ_G0021329
protein coding gene Chr14:103835353-104155920 (-)
DBA/2J MGP_DBA2J_G0021453
protein coding gene Chr14:92617554-92895265 (-)
FVB/NJ MGP_FVBNJ_G0021430
protein coding gene Chr14:91650823-91919036 (-)
LP/J MGP_LPJ_G0021521
protein coding gene Chr14:97010876-97305956 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021457
protein coding gene Chr14:106514862-106813948 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022046
protein coding gene Chr14:95391311-95674494 (-)
PWK/PhJ MGP_PWKPhJ_G0020621
protein coding gene Chr14:89604730-89878906 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020459
protein coding gene Chr14:91368394-91655834 (-)
WSB/EiJ MGP_WSBEiJ_G0020931
protein coding gene Chr14:95989344-96282171 (-)



Homology
more
  • Human Ortholog
    KLF12, Kruppel like factor 12
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KLF12, Kruppel like factor 12
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AP-2rep, AP2REP, HSPC122
  • Links
    NCBI Gene ID: 11278
    neXtProt AC: NX_Q9Y4X4
    UniProt: Q9Y4X4

  • Chr Location
    13q22.1; chr13:73686012-74168295 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 21417
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: KLF12
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000072294 Ensembl Gene Model | MGI Sequence Detail 414048 C57BL/6J ±  kb
transcript ENSMUST00000228216 Ensembl | MGI Sequence Detail 5890 Not Applicable  
polypeptide ENSMUSP00000153901 Ensembl | MGI Sequence Detail 402 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 15
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:1353650, MGI:1919848, MGI:1925972, MGI:2145611
References
more
  • Summaries
    All 54
    Developmental Gene Expression 8
    Gene Ontology 10
    Phenotypes 15
  • Earliest
    J:51610 Imhof A, et al., Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/ egr-related zinc finger repressor. Mol Cell Biol. 1999 Jan;19(1):194-204
  • Latest
    J:220324 De Vas MG, et al., Hnf1b controls pancreas morphogenesis and the generation of Ngn3+ endocrine progenitors. Development. 2015 Mar 1;142(5):871-82

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory