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Srp72 Gene Detail
Summary
  • Symbol
    Srp72
  • Name
    signal recognition particle 72
  • Synonyms
    5730576P14Rik, 72kDa
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333795
    NCBI Gene: 66661
Location & Maps
more
  • Sequence Map
    Chr5:76974683-76999937 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25255 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 41.45 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SRP72, signal recognition particle 72
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SRP72, signal recognition particle 72
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BMFF, BMFS1, HEL103
  • Links
    NCBI Gene ID: 6731
    neXtProt AC: NX_O76094

  • Chr Location
    4q11; chr4:56467596-56503681 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 38254
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: SRP72
  • Protein SuperFamily
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human SRP72 associations

Human Disease Mouse Models
       Bone Marrow Failure Syndrome 1; BMFS1   OMIM: 614675
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    2
  • Gene trapped
    6
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    3 involving Srp72
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026549 VEGA Gene Model | MGI Sequence Detail 25255 C57BL/6J ±  kb
transcript OTTMUST00000065682 VEGA | MGI Sequence Detail 3625 Not Applicable  
polypeptide OTTMUSP00000032768 VEGA | MGI Sequence Detail 671 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    123 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • InterPro Domains
    IPR031545 Putative TPR-like repeat
    IPR026270 Signal recognition particle, SRP72 subunit
    IPR013699 Signal recognition particle, SRP72 subunit, RNA-binding
    IPR011990 Tetratricopeptide-like helical domain
    IPR019734 Tetratricopeptide repeat
    IPR013026 Tetratricopeptide repeat-containing domain
Molecular
Reagents
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  • All nucleic 12
    cDNA 12

    Microarray probesets 6
Other
Accession IDs
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MGI:1913911, MGI:2140810, MGI:2141290, MGI:3039569
References
more
  • Summaries
    All 31
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:51619 Utz PJ, et al., The 72-kDa component of signal recognition particle is cleaved during apoptosis. J Biol Chem. 1998 Dec 25;273(52):35362-70
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory