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Magea2 Gene Detail
Summary
  • Symbol
    Magea2
  • Name
    MAGE family member A2
  • Synonyms
    Mage-a2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333793
    NCBI Gene: 17138
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    ChrX:153810197-153816309 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 72.38 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    14 from dbSNP Build 142
  • Strain Annotations
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333793
 protein coding gene ChrX:153810197-153876662 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0036017
 protein coding gene ChrX:151086744-151088332 (-)
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0036731
 protein coding gene ChrX:152425981-152427340 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0035302
 protein coding gene ChrX:150358543-150444810 (-)



Homology
more
  • Human Ortholog
    MAGEA10, MAGE family member A10
  • Vertebrate Orthologs
    8
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAGEA10, MAGE family member A10
  • Synonyms
    CT1.10, MAGE10
  • Links
    NCBI Gene ID: 4109
    neXtProt AC: NX_P43363
    UniProt: P43363

  • Chr Location
    Xq28; chrX:152133310-152138578 (-)  GRCh38
  • Human Ortholog
    MAGEA12, MAGE family member A12
  • Synonyms
    CT1.12, MAGE12
  • Links
    NCBI Gene ID: 4111
    neXtProt AC: NX_P43365
    UniProt: P43365

  • Chr Location
    Xq28; chrX:152733757-152737669 (+)  GRCh38
  • Human Ortholog
    MAGEA2, MAGE family member A2
  • Synonyms
    CT1.2, MAGE2, MAGEA2A
  • Links
    NCBI Gene ID: 4101
    neXtProt AC: NX_P43356
    UniProt: P43356

  • Chr Location
    Xq28
  • Human Ortholog
    MAGEA2B, MAGE family member A2B
  • Synonyms
    CT1.2, MAGE2
  • Links
    NCBI Gene ID: 266740
    neXtProt AC: NX_P43356
    UniProt: P43356

  • Chr Location
    Xq28; chrX:152714586-152718607 (+)  GRCh38
  • Human Ortholog
    MAGEA4, MAGE family member A4
  • Synonyms
    CT1.4, MAGE4, MAGE-41, MAGE4A, MAGE4B, MAGE-X2
  • Links
    NCBI Gene ID: 4103
    neXtProt AC: NX_P43358
    UniProt: P43358

  • Chr Location
    Xq28; chrX:151912474-151925171 (+)  GRCh38
  • Human Ortholog
    MAGEA8, MAGE family member A8
  • Synonyms
    CT1.8, MAGE8
  • Links
    NCBI Gene ID: 4107
    neXtProt AC: NX_P43361
    UniProt: P43361

  • Chr Location
    Xq28; chrX:149881141-149885835 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    32
  • cDNA Data
    3
  • Literature Summary
    10
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17138 NCBI Gene Model | MGI Sequence Detail 6113 C57BL/6J ±  kb
transcript NM_020016 RefSeq | MGI Sequence Detail 1685 129  
polypeptide NP_064400 RefSeq | MGI Sequence Detail 320 129  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR002190 MAGE homology domain
    IPR041898 MAGE homology domain, winged helix WH1 motif
    IPR041899 MAGE homology domain, winged helix WH2 motif
    IPR037445 Melanoma-associated antigen
Molecular
Reagents
less
  • All nucleic 5
    cDNA 3
    Primer pair 2

    Microarray probesets 1
References
more
  • Summaries
    All 26
    Developmental Gene Expression 10
    Gene Ontology 2
    Phenotypes 1
  • Earliest
    J:52871 De Plaen E, et al., A new family of mouse genes homologous to the human MAGE genes. Genomics. 1999 Jan 15;55(2):176-84
  • Latest
    J:342299 Fon Tacer K, et al., MAGE cancer-testis antigens protect the mammalian germline under environmental stress. Sci Adv. 2019 May;5(5):eaav4832
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory