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Hs3st4 Gene Detail
Summary
  • Symbol
    Hs3st4
  • Name
    heparan sulfate (glucosamine) 3-O-sulfotransferase 4
  • Synonyms
    Gm6915
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333792
    NCBI Gene: 628779
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:123983181-124398989 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 67.56 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2963 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333792
protein coding gene Chr7:123982869-124398989 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032965
protein coding gene Chr7:128151988-128592724 (+)
A/J MGP_AJ_G0032948
protein coding gene Chr7:124801867-125225125 (+)
AKR/J MGP_AKRJ_G0032880
protein coding gene Chr7:127976705-128412755 (+)
BALB/cJ MGP_BALBcJ_G0032953
protein coding gene Chr7:124463677-124886745 (+)
C3H/HeJ MGP_C3HHeJ_G0032663
protein coding gene Chr7:127885469-128319259 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033459
protein coding gene Chr7:133152955-133597866 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030431
protein coding gene Chr7:126068114-126474536 (+)
CAST/EiJ MGP_CASTEiJ_G0031991
protein coding gene Chr7:119678778-120114970 (+)
CBA/J MGP_CBAJ_G0032636
protein coding gene Chr7:137630423-138099813 (+)
DBA/2J MGP_DBA2J_G0032788
protein coding gene Chr7:122791735-123208785 (+)
FVB/NJ MGP_FVBNJ_G0032741
protein coding gene Chr7:122632832-123051641 (+)
LP/J MGP_LPJ_G0032882
protein coding gene Chr7:129584872-130029517 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032773
protein coding gene Chr7:138946015-139386194 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033479
protein coding gene Chr7:126969653-127404071 (+)
PWK/PhJ MGP_PWKPhJ_G0031699
protein coding gene Chr7:115751352-116178254 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031545
protein coding gene Chr7:113789660-114233519 (+)
WSB/EiJ MGP_WSBEiJ_G0032104
protein coding gene Chr7:127898614-128346716 (+)



Homology
more
  • Human Ortholog
    HS3ST4, heparan sulfate-glucosamine 3-sulfotransferase 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HS3ST4, heparan sulfate-glucosamine 3-sulfotransferase 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    30ST4, 3OST4, 3-OST-4, h3-OST-4
  • Links
    NCBI Gene ID: 9951
    neXtProt AC: NX_Q9Y661
    UniProt: Q9Y661

  • Chr Location
    16p12.1; chr16:25692026-26137688 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 82444
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: HS3ST4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 628779 NCBI Gene Model | MGI Sequence Detail 415809 C57BL/6J ±  kb
transcript NM_001252072 RefSeq | MGI Sequence Detail 3230 C57BL/6  
polypeptide NP_001239001 RefSeq | MGI Sequence Detail 449 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • EC
  • InterPro Domains
    IPR037359 Heparan sulfate sulfotransferase
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR000863 Sulfotransferase domain
Molecular
Reagents
less
  • All nucleic 7
    cDNA 5
    Primer pair 2

    Microarray probesets 2
Other
Accession IDs
less
MGI:3645059
References
more
  • Summaries
    All 22
    Developmental Gene Expression 5
    Gene Ontology 2
    Phenotypes 1
  • Earliest
    J:53037 Shworak NW, et al., Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci. J Biol Chem. 1999 Feb 19;274(8):5170-84
  • Latest
    J:238433 Caubit X, et al., TSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons. Nat Genet. 2016 Nov;48(11):1359-1369

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory