Inppl1
Gene Detail

Symbol Name ID

Inppl1 inositol polyphosphate phosphatase-like 1 MGI:1333787

Synonyms

SHIP2

Feature Type

protein coding gene

Genetic Map

Chromosome 7

54.67 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:101822633-101838226 bp, - strand From Ensembl annotation of GRCm38   15594 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1204  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Inppl1

Human homologs

Human Homolog		INPPL1, inositol polyphosphate phosphatase-like 1
NCBI Gene ID		3636
neXtProt AC		NX_O15357
Human Synonyms		OPSMD, SHIP2
Human Chr (Location)		11q13; chr11:71935882-71950191 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(14) : Targeted(4) Gene trapped(10)
 

Homozygous mice display decreased postnatal growth, decreased circulating levels of leptin, free fatty acids, triglycerides, and total cholesterol, and resistance to diet-induced obesity.

 

Gene Ontology (GO) classifications

All GO classifications: (33 annotations)

Process	actin filament organization, cell adhesion, ...
Component	cytoplasm, cytoskeleton, ...
Function	actin binding, hydrolase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (184)    Tissues (125)    Images (36)
Theiler Stages: 22, 23, 28

Assay Type	Results
RNA in situ	163
RT-PCR	21

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) cDNA(12) Primer pair(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000032737 (Evidence)
Entrez Gene	16332 (Evidence)
DFCI	TC1575035, TC1673869, TC1702200, TC1706225
EC	3.1.3.86
Consensus CDS Project	CCDS21515.1
International Mouse Knockout Project Status	Inppl1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000032737	Ensembl Gene Model | MGI Sequence Detail	15594	C57BL/6J
transcript	ENSMUST00000035836	Ensembl | MGI Sequence Detail	4991	Not Applicable
polypeptide	ENSMUSP00000048057	Ensembl | MGI Sequence Detail	1257	Not Applicable

All sequences(47) RefSeq(4) UniProt(1)

Polymorphisms

SNPs(35 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005135	Endonuclease/exonuclease/phosphatase
InterPro	IPR000300	Inositol polyphosphate-related phosphatase
InterPro	IPR000980	SH2 domain
InterPro	IPR001660	Sterile alpha motif domain
InterPro	IPR013761	Sterile alpha motif/pointed domain
InterPro	IPR011510	Sterile alpha motif, type 2
Protein Ontology	PR:000009053	phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2

References

(Earliest) J:51726 Yamabhai M, et al., Examining the specificity of Src homology 3 domain--ligand interactions with alkaline phosphatase fusion proteins. Anal Biochem. 1997 Apr 5;247(1):143-51
(Latest) J:187704 Yoshinaga S, et al., A Phosphatidylinositol Lipids System, Lamellipodin, and Ena/VASP Regulate Dynamic Morphology of Multipolar Migrating Cells in the Developing Cerebral Cortex. J Neurosci. 2012 Aug 22;32(34):11643-56
All references(40)