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Inppl1 Gene Detail
Summary
  • Symbol
    Inppl1
  • Name
    inositol polyphosphate phosphatase-like 1
  • Synonyms
    SHIP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333787
    NCBI Gene: 16332
  • Gene Overview
    MyGene.info: INPPL1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:101822632-101838226 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 54.67 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    56 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333787
protein coding gene Chr7:101822632-101838229 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032588
protein coding gene Chr7:104834111-104849577 (-)
A/J MGP_AJ_G0032564
protein coding gene Chr7:102166014-102181482 (-)
AKR/J MGP_AKRJ_G0032500
protein coding gene Chr7:104611849-104627121 (-)
BALB/cJ MGP_BALBcJ_G0032575
protein coding gene Chr7:101865501-101880733 (-)
C3H/HeJ MGP_C3HHeJ_G0032289
protein coding gene Chr7:104982669-104999840 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033072
protein coding gene Chr7:108780679-108795853 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030066
protein coding gene Chr7:104520644-104536055 (-)
CAST/EiJ MGP_CASTEiJ_G0031615
protein coding gene Chr7:96533834-96550025 (-)
CBA/J MGP_CBAJ_G0032255
protein coding gene Chr7:112547949-112563101 (-)
DBA/2J MGP_DBA2J_G0032407
protein coding gene Chr7:100493995-100509430 (-)
FVB/NJ MGP_FVBNJ_G0032363
protein coding gene Chr7:100274888-100290010 (-)
LP/J MGP_LPJ_G0032496
protein coding gene Chr7:106151092-106166560 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032397
protein coding gene Chr7:113884238-113899936 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033094
protein coding gene Chr7:103872548-103888173 (-)
PWK/PhJ MGP_PWKPhJ_G0031333
protein coding gene Chr7:93603642-93619405 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031177
protein coding gene Chr7:91163329-91179017 (-)
WSB/EiJ MGP_WSBEiJ_G0031732
protein coding gene Chr7:104563573-104579102 (-)



Homology
more
  • Human Ortholog
    INPPL1, inositol polyphosphate phosphatase like 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    INPPL1, inositol polyphosphate phosphatase like 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    OPSMD, SHIP2
  • Links
    NCBI Gene ID: 3636
    neXtProt AC: NX_O15357
    UniProt: O15357

  • Chr Location
    11q13.4; chr11:72223861-72239147 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mice display decreased postnatal growth, decreased circulating levels of leptin, free fatty acids, triglycerides, and total cholesterol, and resistance to diet-induced obesity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16332 NCBI Gene Model | MGI Sequence Detail 15595 C57BL/6J ±  kb
    transcript NM_010567 RefSeq | MGI Sequence Detail 5012 C57BL/6  
    polypeptide Q6P549 UniProt | EBI | MGI Sequence Detail 1257 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 84
      cDNA 82
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 7
      Gene Ontology 9
      Phenotypes 17
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:249116 Watt NT, et al., Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase-Dependent Vascular Oxidative Stress, Endothelial Dysfunction, and Systemic Insulin Resistance. Diabetes. 2017 Nov;66(11):2808-2821

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory