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Inppl1
Gene Detail
 Symbol
Name
ID
Inppl1
inositol polyphosphate phosphatase-like 1
MGI:1333787
Synonyms SHIP2
Feature Type protein coding gene
Genetic Map
Chromosome 7
54.67 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:101822632-101838076 bp, - strand
From VEGA annotation of GRCm38

  15445 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1204  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Inppl1

Human
homologs
Human Homolog INPPL1, inositol polyphosphate phosphatase-like 1
NCBI Gene ID 3636
neXtProt AC  NX_O15357
Human Synonyms  OPSMD, SHIP2
Human Chr (Location)  11q13; chr11:72223875-72239147 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human INPPL1
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(10) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mice display decreased postnatal growth, decreased circulating levels of leptin, free fatty acids, triglycerides, and total cholesterol, and resistance to diet-induced obesity.
 
Interactions
Inppl1 interacts with 82 markers (Mir17, Mir18, Mir18b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process actin filament organization, cell adhesion, ...
Component cell projection, cytoplasm, ...
Function actin binding, hydrolase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (184)    Tissues (125)    Images (36)
Theiler Stages: 22, 23, 28
Assay TypeResults
RNA in situ 163
RT-PCR 21
cDNA source data(81)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(83) cDNA(81) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000046069 (Evidence)
Ensembl Gene ModelENSMUSG00000032737 (Evidence)
Entrez Gene16332 (Evidence)
UniGene476000
DFCITC1575035, TC1673869, TC1702200, TC1706225
EC3.1.3.86
Consensus CDS ProjectCCDS21515.1
International Mouse Knockout Project StatusInppl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046069 VEGA Gene Model | MGI Sequence Detail 15445 C57BL/6J ±  kb
transcript OTTMUST00000120288 VEGA | MGI Sequence Detail 4842 Not Applicable 
polypeptide OTTMUSP00000066653 VEGA | MGI Sequence Detail 1257 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(9) UniProt(1)
Polymorphisms SNPs within 2kb(57 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005135 Endonuclease/exonuclease/phosphatase
InterPro IPR000300 Inositol polyphosphate-related phosphatase
InterPro IPR000980 SH2 domain
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR021129 Sterile alpha motif, type 1
Protein Ontology PR:000009053 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
References (Earliest) J:51726 Yamabhai M, et al., Examining the specificity of Src homology 3 domain--ligand interactions with alkaline phosphatase fusion proteins. Anal Biochem. 1997 Apr 5;247(1):143-51
(Latest) J:201587 Wang D, et al., MicroRNA-205 controls neonatal expansion of skin stem cells by modulating the PI(3)K pathway. Nat Cell Biol. 2013 Oct;15(10):1153-63
All references(45)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory