Car6
Gene Detail

Symbol Name ID

Car6 carbonic anhydrase 6 MGI:1333786

Synonyms

DOC1

Feature Type

protein coding gene

Genetic Map

Chromosome 4

81.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr4:150187015-150201332 bp, - strand From VEGA annotation of GRCm38   14318 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20324  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: carbonate dehydratase
Gene Tree: Car6

Human homologs

Human Homolog		CA6, carbonic anhydrase VI
NCBI Gene ID		765
neXtProt AC		NX_P23280
Human Synonyms		CA-VI, GUSTIN
Human Chr (Location)		1p36.2; chr1:9005893-9035151 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(3) Gene trapped(4)
 

Mice homozygous for a knock-out allele exhibit increase in the number of lymphoid follicles in Peyer's patches.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	metabolic process, one-carbon metabolic process
Component	cytoplasm, extracellular region, ...
Function	carbonate dehydratase activity, lyase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (95)    Tissues (95)    Images (1)
Theiler Stages: 22, 25

Assay Type	Results
RNA in situ	94
RT-PCR	1

cDNA source data(920)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(923) cDNA(920) Primer pair(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000010399 (Evidence)
Ensembl Gene Model	ENSMUSG00000028972 (Evidence)
Entrez Gene	12353 (Evidence)
UniGene	232523
DFCI	TC1573909
DoTS	DT.531222, DT.91564545
NIA Mouse Gene Index	U025816
EC	4.2.1.1
Consensus CDS Project	CCDS51386.1
International Mouse Knockout Project Status	Car6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010399	VEGA Gene Model | MGI Sequence Detail	14318	C57BL/6J
transcript	OTTMUST00000024247	VEGA | MGI Sequence Detail	1567	Not Applicable
polypeptide	OTTMUSP00000011152	VEGA | MGI Sequence Detail	317	Not Applicable

All sequences(42) RefSeq(2) UniProt(9)

Polymorphisms

SNPs(46 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001148	Alpha carbonic anhydrase
InterPro	IPR023561	Carbonic anhydrase, alpha-class
InterPro	IPR018428	Carbonic anhydrase, CA-VI
Protein Ontology	PR:000004923	carbonic anhydrase 6

References

(Earliest) J:50817 Wang XZ, et al., Identification of novel stress-induced genes downstream of chop. EMBO J. 1998 Jul 1;17(13):3619-30
(Latest) J:193048 Wu L, et al., A systematic survey of carbonic anhydrase mRNA expression during Mammalian inner ear development. Dev Dyn. 2013 Mar;242(3):269-80
All references(35)