About   Help   FAQ
Hdac5
Gene Detail
Symbol

Name
ID
Hdac5
histone deacetylase 5
MGI:1333784
Synonyms
mHDA1, mKIAA0600
Feature Type
protein coding gene
Genetic Map
Chromosome 11
65.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:102194432-102230166 bp, - strand
From VEGA annotation of GRCm38

  35735 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3995  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HDAC5
Protein SuperFamily: histone deacetylase class II, eukaryotic type
Gene Tree: Hdac5

Human
homologs
HDAC5, histone deacetylase 5
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10014
neXtProt AC: NX_Q9UQL6

Human Synonyms: HD5, NY-CO-9

Human Chr (Location): 17q21; chr17:44076753-44123646 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(3) Targeted(2)
Genomic Mutations involving Hdac5 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice are viable and display cardiac hypertrophy.
 
Interactions
Hdac5 interacts with 349 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (88 annotations)
Process B cell activation, B cell differentiation, ...
Component cytoplasm, cytosol, ...
Function chromatin binding, core promoter binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (127)    Tissues (49)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 85
Western blot 6
RT-PCR 36
cDNA source data(138)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase hdac5    NEW 
Molecular
reagents
All nucleic(139) cDNA(138) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000002621 (Evidence)
Ensembl Gene Model ENSMUSG00000008855 (Evidence)
Entrez Gene 15184 (Evidence)
UniGene 22665
DFCI TC1574127, TC1624712
DoTS DT.101252326, DT.101331212, DT.101377294, DT.101384248, DT.97410888
NIA Mouse Gene Index U033470
EC 3.5.1.98
Consensus CDS Project CCDS36341.1, CCDS70320.1, CCDS70321.1
International Mouse Phenotyping Consortium Status Hdac5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002621 VEGA Gene Model | MGI Sequence Detail 35735 C57BL/6J ±  kb
transcript OTTMUST00000005098 VEGA | MGI Sequence Detail 4269 Not Applicable 
polypeptide OTTMUSP00000030251 VEGA | MGI Sequence Detail 1121 Not Applicable 

For the selected sequences
All sequences(152) RefSeq(31) UniProt(13)
Polymorphisms
SNPs within 2kb(87 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR030703 Histone deacetylase 5
InterPro IPR017320 Histone deacetylase class II, eukaryotic
InterPro IPR023801 Histone deacetylase domain
InterPro IPR024643 Histone deacetylase, glutamine rich N-terminal domain
InterPro IPR000286 Histone deacetylase superfamily
Protein Ontology PR:000008484 histone deacetylase 5
References
(Earliest) J:52197 Verdel A, et al., Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers. J Biol Chem. 1999 Jan 22;274(4):2440-5
(Latest) J:215793 Obri A, et al., HDAC4 integrates PTH and sympathetic signaling in osteoblasts. J Cell Biol. 2014 Jun 23;205(6):771-80
All references(79)
Other
accession IDs
MGI:2144155

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory