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Hdac5 Gene Detail
Summary
  • Symbol
    Hdac5
  • Name
    histone deacetylase 5
  • Synonyms
    mHDA1, mKIAA0600
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333784
    NCBI Gene: 15184
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:102085244-102120968 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 65.82 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    87 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333784
protein coding gene Chr11:102085244-102120992 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019226
protein coding gene Chr11:105147105-105182875 (-)
A/J MGP_AJ_G0019194
protein coding gene Chr11:100708268-100744502 (-)
AKR/J MGP_AKRJ_G0019163
protein coding gene Chr11:103827897-103863360 (-)
BALB/cJ MGP_BALBcJ_G0019168
protein coding gene Chr11:101196395-101232416 (-)
C3H/HeJ MGP_C3HHeJ_G0018977
protein coding gene Chr11:104029447-104066284 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019617
protein coding gene Chr11:108423024-108459169 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017243
protein coding gene Chr11:98138095-98174524 (-)
CAST/EiJ MGP_CASTEiJ_G0018531
protein coding gene Chr11:105004153-105041182 (-)
CBA/J MGP_CBAJ_G0018946
protein coding gene Chr11:112894934-112935541 (-)
DBA/2J MGP_DBA2J_G0019058
protein coding gene Chr11:100232497-100268237 (-)
FVB/NJ MGP_FVBNJ_G0019048
protein coding gene Chr11:99760705-99796835 (-)
LP/J MGP_LPJ_G0019127
protein coding gene Chr11:105668898-105704358 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019079
protein coding gene Chr11:112418317-112455067 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019655
protein coding gene Chr11:104187625-104223196 (-)
PWK/PhJ MGP_PWKPhJ_G0018294
protein coding gene Chr11:101294645-101330966 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018086
protein coding gene Chr11:103945205-103983734 (-)
WSB/EiJ MGP_WSBEiJ_G0018580
protein coding gene Chr11:104180422-104219342 (-)



Homology
more
  • Human Ortholog
    HDAC5, histone deacetylase 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HDAC5, histone deacetylase 5
  • Synonyms
    HD5, NY-CO-9
  • Links
    NCBI Gene ID: 10014
    neXtProt AC: NX_Q9UQL6
    UniProt: Q9UQL6

  • Chr Location
    17q21.31; chr17:44076746-44123702 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    11 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and display cardiac hypertrophy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15184 NCBI Gene Model | MGI Sequence Detail 35725 C57BL/6J ±  kb
    transcript NM_001284248 RefSeq | MGI Sequence Detail 5613 C57BL/6  
    polypeptide Q9Z2V6 UniProt | EBI | MGI Sequence Detail 1113 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 142
      cDNA 139
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2144155
    References
    more
    • Summaries
      All 129
      Developmental Gene Expression 26
      Gene Ontology 28
      Phenotypes 39
    • Earliest
      J:52197 Verdel A, et al., Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers. J Biol Chem. 1999 Jan 22;274(4):2440-5
    • Latest
      J:343966 Velasco-Aviles S, et al., A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair. Elife. 2022 Jan 25;11:e72917

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory