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Rps19 Gene Detail
Summary
  • Symbol
    Rps19
  • Name
    ribosomal protein S19
  • Synonyms
    Dsk3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333780
    NCBI Gene: 20085
  • Gene Overview
    MyGene.info: RPS19
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:24884376-24889806 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 13.41 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    33 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333780
protein coding gene Chr7:24884371-24889806 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031846
protein coding gene Chr7:23294671-23300104 (+)
A/J MGP_AJ_G0031825
protein coding gene Chr7:22721257-22726697 (+)
AKR/J MGP_AKRJ_G0031754
protein coding gene Chr7:23252370-23260607 (+)
BALB/cJ MGP_BALBcJ_G0031833
protein coding gene Chr7:22927048-22932481 (+)
C3H/HeJ MGP_C3HHeJ_G0031551
protein coding gene Chr7:23667673-23673126 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032294
protein coding gene Chr7:24065653-24073828 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029349
protein coding gene Chr7:24155019-24160328 (+)
CAST/EiJ MGP_CASTEiJ_G0030891
protein coding gene Chr7:17144844-17150972 (+)
CBA/J MGP_CBAJ_G0031516
protein coding gene Chr7:24948390-24955764 (+)
DBA/2J MGP_DBA2J_G0031670
protein coding gene Chr7:22626364-22631798 (+)
FVB/NJ MGP_FVBNJ_G0031623
protein coding gene Chr7:22603359-22608855 (+)
LP/J MGP_LPJ_G0031749
protein coding gene Chr7:23604751-23610262 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031660
protein coding gene Chr7:24689713-24695838 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032326
protein coding gene Chr7:22952432-22958197 (+)
PWK/PhJ MGP_PWKPhJ_G0030615
protein coding gene Chr7:17555010-17560599 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030446
protein coding gene Chr7:14263760-14269216 (+)
WSB/EiJ MGP_WSBEiJ_G0030995
protein coding gene Chr7:23112320-23117750 (+)



Homology
more
  • Human Ortholog
    RPS19, ribosomal protein S19
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RPS19, ribosomal protein S19
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DBA, DBA1, eS19, S19
  • Links
    NCBI Gene ID: 6223
    neXtProt AC: NX_P39019
    UniProt: P39019

  • Chr Location
    19q13.2; chr19:41859918-41871416 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human RPS19 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    66
  • Chemically induced (ENU)
    1
  • Gene trapped
    59
  • Targeted
    5
  • Transgenic
    1
  • Genomic Mutations
    2 involving Rps19
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Homozygous null embryos die prior to the formation of a blastocyst. Mice heterozygous for some point mutations show pigment defects affecting the feet and tail.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20085 NCBI Gene Model | MGI Sequence Detail 5431 C57BL/6J ±  kb
transcript NM_023133 RefSeq | MGI Sequence Detail 676 C57BL/6  
polypeptide Q9CZX8 UniProt | EBI | MGI Sequence Detail 145 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • InterPro Domains
    IPR001266 Ribosomal protein S19e
    IPR018277 Ribosomal protein S19e, conserved site
    IPR038111 Ribosomal protein S19e domain superfamily
    IPR036390 Winged helix DNA-binding domain superfamily
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 6
Other
Accession IDs
less
MGI:2450683
References
more
  • Summaries
    All 52
    Developmental Gene Expression 4
    Diseases 2
    Gene Ontology 8
    Phenotypes 18
  • Earliest
    J:52537 Draptchinskaia N, et al., The gene encoding ribosomal protein S19 is mutated in Diamond-Blackfan anaemia. Nat Genet. 1999 Feb;21(2):169-75
  • Latest
    J:263032 Magella B, et al., Reduced Abd-B Hox function during kidney development results in lineage infidelity. Dev Biol. 2018 Jun 15;438(2):84-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory