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Rps19
Gene Detail
Symbol

Name
ID
Rps19
ribosomal protein S19
MGI:1333780
Synonyms
Dsk3
Feature Type
protein coding gene
Genetic Map
Chromosome 7
13.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:24884371-24889806 bp, + strand
From VEGA annotation of GRCm38

  5436 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37416  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RPS19
Protein SuperFamily: ribosomal protein S19
Gene Tree: Rps19

Human
homologs
RPS19, ribosomal protein S19
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6223
neXtProt AC: NX_P39019

Human Synonyms: DBA, DBA1, S19

Human Chr (Location): 19q13.2; chr19:41859918-41871416 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human RPS19

Mutations,
alleles, and
phenotypes
All mutations/alleles(64) : Chemically induced (ENU)(1) Gene trapped(59) Targeted(3) Transgenic(1)
Incidental mutations (data from APF )
 
Homozygous null embryos die prior to the formation of a blastocyst. Mice heterozygous for some point mutations show pigment defects affecting the feet and tail.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Rps19 interacts with 115 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process erythrocyte differentiation, maturation of SSU-rRNA, ...
Component cytoplasm, cytosol, ...
Function fibroblast growth factor binding, poly(A) RNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (3 records)
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rps19    NEW 
Molecular
reagents
All nucleic(8) cDNA(8)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000022935 (Evidence)
Ensembl Gene Model ENSMUSG00000040952 (Evidence)
Entrez Gene 20085 (Evidence)
DFCI TC1573155, TC1589020
DoTS DT.102553259, DT.538034, DT.97367286
NIA Mouse Gene Index U007810, U056198, U058606, U089620, U095132, U151776, U359026
Consensus CDS Project CCDS20966.1
International Mouse Phenotyping Consortium Status Rps19
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022935 VEGA Gene Model | MGI Sequence Detail 5436 C57BL/6J ±  kb
transcript OTTMUST00000055153 VEGA | MGI Sequence Detail 1284 Not Applicable 
polypeptide OTTMUSP00000026375 VEGA | MGI Sequence Detail 212 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(6) UniProt(7)
Polymorphisms
SNPs within 2kb(33 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001266 Ribosomal protein S19e
InterPro IPR018277 Ribosomal protein S19e, conserved site
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000014261 40S ribosomal protein S19
References
(Earliest) J:52537 Draptchinskaia N, et al., The gene encoding ribosomal protein S19 is mutated in Diamond-Blackfan anaemia. Nat Genet. 1999 Feb;21(2):169-75
(Latest) J:218171 Falix FA, et al., Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning. Dev Biol. 2014 Dec 15;396(2):201-13
All references(47)
Other
accession IDs
MGI:2450683

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory