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Ahrr Gene Detail
Summary
  • Symbol
    Ahrr
  • Name
    aryl-hydrocarbon receptor repressor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333776
    NCBI Gene: 11624
Location & Maps
more
  • Sequence Map
    Chr13:74211118-74292331 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      81214 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 40.15 cM, cytoband C2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    AHRR, aryl-hydrocarbon receptor repressor
  • Vertebrate Orthologs
    7
  • Human Ortholog
    AHRR, aryl-hydrocarbon receptor repressor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AHH, AHHR, bHLHe77
  • Links
    NCBI Gene ID: 57491
    neXtProt AC: NX_A9YTQ3

  • Chr Location
    5p15.3; chr5:304176-438291 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Ahrr
  • Incidental Mutations
Mice homozygous for a null allele exhibit decreased susceptibility to chemically induced tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023058 VEGA Gene Model | MGI Sequence Detail 81214 C57BL/6J ±  kb
transcript OTTMUST00000055581 VEGA | MGI Sequence Detail 4754 Not Applicable  
polypeptide OTTMUSP00000026630 VEGA | MGI Sequence Detail 701 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    616 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000003859 aryl hydrocarbon receptor repressor
  • InterPro Domains
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    IPR000014 PAS domain
    IPR013767 PAS fold
Molecular
Reagents
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  • All nucleic 13
    cDNA 12
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 35
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:52189 Mimura J, et al., Identification of a novel mechanism of regulation of Ah (dioxin) receptor function. Genes Dev. 1999 Jan 1;13(1):20-5
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory