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Mab21l1
Gene Detail
Symbol

Name
ID
Mab21l1
mab-21-like 1 (C. elegans)
MGI:1333773
Feature Type
protein coding gene
Genetic Map
Chromosome 3
26.65 cM, cytoband E3-F1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:55782510-55785285 bp, + strand
From Ensembl annotation of GRCm38

  2776 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36183  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MAB21L1
Gene Tree: Mab21l1

Human
homologs
MAB21L1, mab-21-like 1 (C. elegans)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4081
neXtProt AC: NX_Q13394

Human Synonyms: CAGR1, Nbla00126

Human Chr (Location): 13q13; chr13:35473789-35476695 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from APF )
 
Homozygous mutation of this gene results in male infertility and eye developmental anomalies. Mutant eyes are small, absent of lens and iris, and display malformations of the retina.
 
Interactions
Mab21l1 interacts with 218 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process camera-type eye development, multicellular organismal development, ...
Component nucleus
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (240)    Tissues (104)    Images (81)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 223
Northern blot 16
RT-PCR 1
cDNA source data(41)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA MAB21L1 ; Xenbase mab21l1 ; ZFIN mab21l1    NEW 
Molecular
reagents
All nucleic(45) cDNA(43) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000056947 (Evidence)
Entrez Gene 17116 (Evidence)
UniGene 440209
DFCI TC1580695, TC1680922
NIA Mouse Gene Index U003252
Consensus CDS Project CCDS17360.1
International Mouse Phenotyping Consortium Status Mab21l1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000056947 Ensembl Gene Model | MGI Sequence Detail 2776 C57BL/6J ±  kb
transcript ENSMUST00000075422 Ensembl | MGI Sequence Detail 2776 Not Applicable 
polypeptide ENSMUSP00000074878 Ensembl | MGI Sequence Detail 359 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(22 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024810 Mab-21 domain
InterPro IPR020950 Protein male abnormal 21-related
Protein Ontology PR:000010034 protein mab-21-like 1
References
(Earliest) J:52199 Mariani M, et al., Mab21, the mouse homolog of a C. elegans cell-fate specification gene, participates in cerebellar, midbrain and eye development. Mech Dev. 1998 Dec;79(1-2):131-5
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(36)
Other
accession IDs
MGI:2139952

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory