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Epn1 Gene Detail
Summary
  • Symbol
    Epn1
  • Name
    epsin 1
  • Synonyms
    Ibp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333763
    NCBI Gene: 13854
  • Gene Overview
    MyGene.info: EPN1
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:5080235-5098178 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 2.94 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    141 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333763
protein coding gene Chr7:5080204-5098179 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031584
protein coding gene Chr7:2052910-2072806 (+)
A/J MGP_AJ_G0031558
protein coding gene Chr7:2043662-2062295 (+)
AKR/J MGP_AKRJ_G0031487
protein coding gene Chr7:2120607-2138539 (+)
BALB/cJ MGP_BALBcJ_G0031566
protein coding gene Chr7:2087505-2112549 (+)
C3H/HeJ MGP_C3HHeJ_G0031287
protein coding gene Chr7:2098572-2117325 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032027
protein coding gene Chr7:2123686-2148487 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029151
protein coding gene Chr7:1757421-1775155 (+)
CAST/EiJ MGP_CASTEiJ_G0030651
protein coding gene Chr7:2034902-2055625 (+)
CBA/J MGP_CBAJ_G0031245
protein coding gene Chr7:2327913-2345776 (+)
DBA/2J MGP_DBA2J_G0031404
protein coding gene Chr7:2025939-2047933 (+)
FVB/NJ MGP_FVBNJ_G0031356
protein coding gene Chr7:1968987-1987668 (+)
LP/J MGP_LPJ_G0031489
protein coding gene Chr7:2142619-2162030 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031395
protein coding gene Chr7:2280163-2301108 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032057
protein coding gene Chr7:2024336-2043017 (+)
PWK/PhJ MGP_PWKPhJ_G0030379
protein coding gene Chr7:2177081-2197707 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030204
protein coding gene Chr7:2062016-2084568 (+)
WSB/EiJ MGP_WSBEiJ_G0030746
protein coding gene Chr7:2035015-2054214 (+)



Homology
more
  • Human Ortholog
    EPN1, epsin 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    EPN1, epsin 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 29924
    neXtProt AC: NX_Q9Y6I3
    UniProt: Q9Y6I3

  • Chr Location
    19q13.42; chr19:55675195-55695767 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    30 phenotypes from multigenic genotypes
    7 images
    9 phenotype references
Mice homozygous for a null mutation are viable and fertile with no gross abnormalities. Mice homozygous null for both Epn1 and Epn2 display defects in angiogenic vascular remodeling, impaired somitogenesis and extensive cell death in the nervous tissue, resulting in lethality during organogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035203 Ensembl Gene Model | MGI Sequence Detail 17944 C57BL/6J ±  kb
transcript ENSMUST00000208634 Ensembl | MGI Sequence Detail 2127 Not Applicable  
polypeptide ENSMUSP00000146638 Ensembl | MGI Sequence Detail 576 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 77
    Genomic 2
    cDNA 75

    Microarray probesets 3
Other
Accession IDs
less
MGI:2141801
References
more
  • Summaries
    All 32
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:51614 Yamabhai M, et al., Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains. J Biol Chem. 1998 Nov 20;273(47):31401-7
  • Latest
    J:266192 Wu H, et al., Epsin deficiency promotes lymphangiogenesis through regulation of VEGFR3 degradation in diabetes. J Clin Invest. 2018 Aug 31;128(9):4025-4043

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory