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Strn Gene Detail
Summary
  • Symbol
    Strn
  • Name
    striatin, calmodulin binding protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333757
    NCBI Gene: 268980
  • Gene Overview
    MyGene.info: STRN
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:78649908-78736914 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 49.54 cM, cytoband E3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1057 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333757
protein coding gene Chr17:78649908-78737196 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024039
protein coding gene Chr17:81482640-81573815 (-)
A/J MGP_AJ_G0023996
protein coding gene Chr17:78990605-79072328 (-)
AKR/J MGP_AKRJ_G0023965
protein coding gene Chr17:80185689-80270358 (-)
BALB/cJ MGP_BALBcJ_G0023998
protein coding gene Chr17:78842896-78938460 (-)
C3H/HeJ MGP_C3HHeJ_G0023762
protein coding gene Chr17:81086039-81169888 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024443
protein coding gene Chr17:84447490-84545822 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021886
protein coding gene Chr17:74382630-74468435 (-)
CAST/EiJ MGP_CASTEiJ_G0023242
protein coding gene Chr17:81679830-81774093 (-)
CBA/J MGP_CBAJ_G0023736
protein coding gene Chr17:87994548-88087855 (-)
DBA/2J MGP_DBA2J_G0023865
protein coding gene Chr17:77509044-77591077 (-)
FVB/NJ MGP_FVBNJ_G0023831
protein coding gene Chr17:77024771-77111942 (-)
LP/J MGP_LPJ_G0023948
protein coding gene Chr17:82326648-82417487 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023859
protein coding gene Chr17:88097964-88188344 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024487
protein coding gene Chr17:80660428-80747446 (-)
PWK/PhJ MGP_PWKPhJ_G0022988
protein coding gene Chr17:76998354-77084156 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022799
protein coding gene Chr17:77449525-77540032 (-)
WSB/EiJ MGP_WSBEiJ_G0023309
protein coding gene Chr17:81473208-81565268 (-)



Homology
more
  • Human Ortholog
    STRN, striatin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STRN, striatin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PPP2R6A, SG2NA, STRN1
  • Links
    NCBI Gene ID: 6801
    neXtProt AC: NX_O43815
    UniProt: O43815

  • Chr Location
    2p22.2; chr2:36837698-36966607 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2380
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: STRN
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice heterozygous for a knock-out allele exhibit increased blood pressure and circulating aldosterone when fed a liberal salt diet. No mice could be generated that were homozygous for the allele.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 268980 NCBI Gene Model | MGI Sequence Detail 87007 C57BL/6J ±  kb
    transcript NM_011500 RefSeq | MGI Sequence Detail 3965 C57BL/6  
    polypeptide O55106 UniProt | EBI | MGI Sequence Detail 780 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 22

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2146994
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 7
    • Earliest
      J:49523 Moqrich a, et al., Cloning of human striatin cDNA (STRN), gene mapping to 2p22-p21, and preferential expression in brain. Genomics. 1998 Jul 1;51(1):136-9
    • Latest
      J:236579 Garza AE, et al., Critical Role of Striatin in Blood Pressure and Vascular Responses to Dietary Sodium Intake. Hypertension. 2015 Sep;66(3):674-80

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory