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Agfg1 Gene Detail
Summary
  • Symbol
    Agfg1
  • Name
    ArfGAP with FG repeats 1
  • Synonyms
    C130049H11Rik, D730048C23Rik, Hrb, Rip
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333754
    NCBI Gene: 15463
  • Gene Overview
    MyGene.info: AGFG1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:82839460-82901001 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 42.55 cM, cytoband C5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    358 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333754
protein coding gene Chr1:82839460-82901182 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016220
protein coding gene Chr1:83766338-83829944 (+)
A/J MGP_AJ_G0016203
protein coding gene Chr1:80795566-80857050 (+)
AKR/J MGP_AKRJ_G0016160
protein coding gene Chr1:82999117-83064596 (+)
BALB/cJ MGP_BALBcJ_G0016158
protein coding gene Chr1:80940485-81003627 (+)
C3H/HeJ MGP_C3HHeJ_G0015988
protein coding gene Chr1:83376367-83438727 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016611
protein coding gene Chr1:86988270-87065584 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014331
protein coding gene Chr1:76017848-76085199 (+)
CAST/EiJ MGP_CASTEiJ_G0015574
protein coding gene Chr1:82786848-82863839 (+)
CBA/J MGP_CBAJ_G0015962
protein coding gene Chr1:89784312-89853263 (+)
DBA/2J MGP_DBA2J_G0016063
protein coding gene Chr1:80082465-80144385 (+)
FVB/NJ MGP_FVBNJ_G0016066
protein coding gene Chr1:79179741-79243535 (+)
LP/J MGP_LPJ_G0016136
protein coding gene Chr1:84880297-84948025 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016086
protein coding gene Chr1:93176588-93241795 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016658
protein coding gene Chr1:83163472-83226948 (+)
PWK/PhJ MGP_PWKPhJ_G0015359
protein coding gene Chr1:79527037-79594380 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015137
protein coding gene Chr1:82375094-82445020 (+)
WSB/EiJ MGP_WSBEiJ_G0015634
protein coding gene Chr1:82959395-83023983 (+)



Homology
more
  • Human Ortholog
    AGFG1, ArfGAP with FG repeats 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AGFG1, ArfGAP with FG repeats 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HRB, RAB, RIP
  • Links
    NCBI Gene ID: 3267
    neXtProt AC: NX_P52594
    UniProt: P52594

  • Chr Location
    2q36.3; chr2:227472169-227561222 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 37929
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: AGFG1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Agfg1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Male mice homozygous for disruptions in this gene are infertile as a result of abnormalities in spermatogenesis. Otherwise, males and females are normal and live a normal life span.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 15463 NCBI Gene Model | MGI Sequence Detail 61542 C57BL/6J ±  kb
transcript NM_010472 RefSeq | MGI Sequence Detail 7886 Not Specified  
polypeptide Q8K2K6 UniProt | EBI | MGI Sequence Detail 561 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 9
Other
Accession IDs
less
MGI:1925111, MGI:2138506, MGI:2138706, MGI:2444445
References
more
  • Summaries
    All 46
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 9
    Phenotypes 15
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:224421 Bryant JM, et al., Characterization of BRD4 during mammalian postmeiotic sperm development. Mol Cell Biol. 2015 Apr;35(8):1433-48

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory