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Agfg1 Gene Detail
Summary
  • Symbol
    Agfg1
  • Name
    ArfGAP with FG repeats 1
  • Synonyms
    C130049H11Rik, D730048C23Rik, Hrb, Rip
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333754
    NCBI Gene: 15463
  • Gene Overview
    MyGene.info: AGFG1
Location & Maps
more
  • Sequence Map
    Chr1:82839483-82901182 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      61700 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 42.55 cM, cytoband C5
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    AGFG1, ArfGAP with FG repeats 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AGFG1, ArfGAP with FG repeats 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HRB, RAB, RIP
  • Links
    NCBI Gene ID: 3267
    neXtProt AC: NX_P52594

  • Chr Location
    2q36.3; chr2:227472172-227561222 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 37929
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: AGFG1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    31
  • Chemically induced (other)
    1
  • Gene trapped
    26
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Agfg1
  • Incidental Mutations
Male mice homozygous for disruptions in this gene are infertile as a result of abnormalities in spermatogenesis. Otherwise, males and females are normal and live a normal life span.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047960 VEGA Gene Model | MGI Sequence Detail 61700 C57BL/6J ±  kb
transcript OTTMUST00000123315 VEGA | MGI Sequence Detail 1805 Not Applicable  
polypeptide OTTMUSP00000067378 VEGA | MGI Sequence Detail 580 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    358 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 13
    cDNA 13

    Microarray probesets 9
Other
Accession IDs
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MGI:1925111, MGI:2138506, MGI:2138706, MGI:2444445
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 15
  • Earliest
    J:51614 Yamabhai M, et al., Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains. J Biol Chem. 1998 Nov 20;273(47):31401-7
  • Latest
    J:224421 Bryant JM, et al., Characterization of BRD4 during mammalian postmeiotic sperm development. Mol Cell Biol. 2015 Apr;35(8):1433-48

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory