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Snapin Gene Detail
Summary
  • Symbol
    Snapin
  • Name
    SNAP-associated protein
  • Synonyms
    Bloc1s7, Snap25bp, Snapap
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333745
    NCBI Gene: 20615
Location & Maps
more
  • Sequence Map
    Chr3:90488026-90491033 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3008 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SNAPIN, SNAP associated protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SNAPIN, SNAP associated protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BLOC1S7, BLOS7, SNAPAP
  • Links
    NCBI Gene ID: 23557
    neXtProt AC: NX_O95295

  • Chr Location
    1q21.3; chr1:153658654-153661852 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Snapin
  • Incidental Mutations
Homozygous mice die shortly after birth. No obvious brain morphological abnormalities are seen. Calcium-dependent exocytosis in adrenal chromaffin cells is reduced due to a reduced number of secretory vesicles in releasable pools.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022106 VEGA Gene Model | MGI Sequence Detail 3008 C57BL/6J ±  kb
transcript OTTMUST00000052477 VEGA | MGI Sequence Detail 1928 Not Applicable  
polypeptide OTTMUSP00000024888 VEGA | MGI Sequence Detail 136 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    25 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 17

    Microarray probesets 5
Other
Accession IDs
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MGI:2139556, MGI:2139928
References
more
  • Summaries
    All 49
    Developmental Gene Expression 1
    Gene Ontology 16
    Phenotypes 15
  • Earliest
    J:52524 Ilardi JM, et al., Snapin: a SNARE-associated protein implicated in synaptic transmission [see comments]. Nat Neurosci. 1999 Feb;2(2):119-24
  • Latest
    J:207508 Ye X, et al., Snapin-mediated BACE1 retrograde transport is essential for its degradation in lysosomes and regulation of APP processing in neurons. Cell Rep. 2014 Jan 16;6(1):24-31

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory