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Snapin
Gene Detail
Symbol

Name
ID
Snapin
SNAP-associated protein
MGI:1333745
Synonyms
Bloc1s7, Snap25bp, Snapap
Feature Type
protein coding gene
Genetic Map
Chromosome 3
39.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:90488026-90491033 bp, - strand
From VEGA annotation of GRCm38

  3008 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8251  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: snapin
Gene Tree: Snapin

Human
homologs
Human Homolog SNAPIN, SNAP-associated protein
NCBI Gene ID 23557
neXtProt AC  NX_O95295
Human Synonyms  BLOC1S7, BLOS7, SNAPAP
Human Chr (Location)  1q21.3; chr1:153658654-153661852 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(4) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mice die shortly after birth. No obvious brain morphological abnormalities are seen. Calcium-dependent exocytosis in adrenal chromaffin cells is reduced due to a reduced number of secretory vesicles in releasable pools.
 
Interactions
Snapin interacts with 182 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process anterograde axon cargo transport, anterograde synaptic vesicle transport, ...
Component BLOC-1 complex, cell, ...
Function protein binding, SNARE binding
External Resources: FuncBase
Expression
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(17)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000022106 (Evidence)
Ensembl Gene ModelENSMUSG00000001018 (Evidence)
Entrez Gene20615 (Evidence)
DFCITC1645361, TC1572077
NIA Mouse Gene IndexU024300
Consensus CDS ProjectCCDS17531.1
International Mouse Knockout Project StatusSnapin
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022106 VEGA Gene Model | MGI Sequence Detail 3008 C57BL/6J ±  kb
transcript OTTMUST00000052477 VEGA | MGI Sequence Detail 1928 Not Applicable 
polypeptide OTTMUSP00000024888 VEGA | MGI Sequence Detail 136 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(2) UniProt(7)
Polymorphisms
SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017246 Snapin
Protein Ontology PR:000015321 SNARE-associated protein Snapin
References
(Earliest) J:52524 Ilardi JM, et al., Snapin: a SNARE-associated protein implicated in synaptic transmission [see comments]. Nat Neurosci. 1999 Feb;2(2):119-24
(Latest) J:207508 Ye X, et al., Snapin-mediated BACE1 retrograde transport is essential for its degradation in lysosomes and regulation of APP processing in neurons. Cell Rep. 2014 Jan 16;6(1):24-31
All references(49)
Other
accession IDs
MGI:2139556, MGI:2139928

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory