About   Help   FAQ
Gp1ba Gene Detail
Summary
  • Symbol
    Gp1ba
  • Name
    glycoprotein 1b, alpha polypeptide
  • Synonyms
    GPIba, GP Ib-alpha, GPIb-alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333744
    NCBI Gene: 14723
  • Gene Overview
    MyGene.info: GP1BA
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:70639122-70642036 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 43.20 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    38 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333744
protein coding gene Chr11:70639042-70642058 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018606
protein coding gene Chr11:71182312-71185226 (+)
A/J MGP_AJ_G0018574
protein coding gene Chr11:68493718-68496632 (+)
AKR/J MGP_AKRJ_G0018543
protein coding gene Chr11:70550990-70553904 (+)
BALB/cJ MGP_BALBcJ_G0018546
protein coding gene Chr11:68802859-68805773 (+)
C3H/HeJ MGP_C3HHeJ_G0018359
protein coding gene Chr11:70569637-70572551 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018997
protein coding gene Chr11:73339438-73342352 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016642
protein coding gene Chr11:65401739-65404598 (+)
CAST/EiJ MGP_CASTEiJ_G0017914
protein coding gene Chr11:70827004-70829918 (+)
CBA/J MGP_CBAJ_G0018331
protein coding gene Chr11:76643104-76646018 (+)
DBA/2J MGP_DBA2J_G0018441
protein coding gene Chr11:68067000-68069914 (+)
FVB/NJ MGP_FVBNJ_G0018431
protein coding gene Chr11:67707735-67710601 (+)
LP/J MGP_LPJ_G0018511
protein coding gene Chr11:71762965-71765879 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018454
protein coding gene Chr11:77198216-77201130 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019039
protein coding gene Chr11:70806869-70809783 (+)
PWK/PhJ MGP_PWKPhJ_G0017688
protein coding gene Chr11:68714083-68716997 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017478
protein coding gene Chr11:70622376-70625328 (+)
WSB/EiJ MGP_WSBEiJ_G0017968
protein coding gene Chr11:70467612-70470526 (+)



Homology
more
  • Human Ortholog
    GP1BA, glycoprotein Ib platelet subunit alpha
  • Vertebrate Orthologs
    5
  • Human Ortholog
    GP1BA, glycoprotein Ib platelet subunit alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BDPLT1, BDPLT3, BSS, CD42B, CD42b-alpha, DBPLT3, GP1B, GPIbA, GPIbalpha, VWDP
  • Links
    NCBI Gene ID: 2811
    neXtProt AC: NX_P07359
    UniProt: P07359

  • Chr Location
    17p13.2; chr17:4932275-4935030 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Gp1ba mouse models; 4 with human GP1BA associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit prolonged bleeding times and reduced numbers of enlarged platelets. Heterozygotes have intermediate numbers of platelets.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050675 Ensembl Gene Model | MGI Sequence Detail 2915 C57BL/6J ±  kb
transcript ENSMUST00000108551 Ensembl | MGI Sequence Detail 2480 Not Applicable  
polypeptide ENSMUSP00000104191 Ensembl | MGI Sequence Detail 734 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    Genomic 4
    cDNA 2
    Primer pair 1
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 74
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 11
    Phenotypes 35
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:266091 Xu M, et al., GPIbalpha is required for platelet-mediated hepatic thrombopoietin generation. Blood. 2018 Aug 9;132(6):622-634

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/13/2018
MGI 6.13
The Jackson Laboratory