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Gp1ba Gene Detail
Summary
  • Symbol
    Gp1ba
  • Name
    glycoprotein 1b, alpha polypeptide
  • Synonyms
    GPIba, GP Ib-alpha, GPIb-alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333744
    NCBI Gene: 14723
  • Gene Overview
    MyGene.info: GP1BA
Location & Maps
more
  • Sequence Map
    Chr11:70639144-70641820 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2677 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 43.20 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GP1BA, glycoprotein Ib platelet alpha subunit
  • Vertebrate Orthologs
    5
  • Human Ortholog
    GP1BA, glycoprotein Ib platelet alpha subunit
    Orthology source: HomoloGene
  • Synonyms
    BDPLT1, BDPLT3, BSS, CD42B, CD42b-alpha, DBPLT3, GP1B, GPIbA, GPIbalpha, VWDP
  • Links
    NCBI Gene ID: 2811
    neXtProt AC: NX_P07359

  • Chr Location
    17p13.2; chr17:4932275-4935030 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Gp1ba mouse models; 4 with human GP1BA associations

Human Disease Mouse Models
       Bernard-Soulier Syndrome; BSS   OMIM: 231200 View 1 model
       Bernard-Soulier Syndrome, Type A2, Autosomal Dominant; BSSA2   OMIM: 153670
Nonarteritic Anterior Ischemic Optic Neuropathy, Susceptibility to   OMIM: 258660
Pseudo-Von Willebrand Disease; VWDP   OMIM: 177820
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Gp1ba
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit prolonged bleeding times and reduced numbers of enlarged platelets. Heterozygotes have intermediate numbers of platelets.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006072 VEGA Gene Model | MGI Sequence Detail 2677 C57BL/6J ±  kb
transcript OTTMUST00000013696 VEGA | MGI Sequence Detail 2480 Not Applicable  
polypeptide OTTMUSP00000006354 VEGA | MGI Sequence Detail 734 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    38 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001907 platelet glycoprotein Ib alpha chain
  • PDB
  • InterPro Domains
    IPR000483 Cysteine-rich flanking region, C-terminal
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR003591 Leucine-rich repeat, typical subtype
Molecular
Reagents
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  • All nucleic 6
    Genomic 4
    cDNA 1
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 52
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 10
    Phenotypes 32
  • Earliest
    J:49049 Ware J, et al., Cloning of the murine platelet glycoprotein Ibalpha gene highlighting species-specific platelet adhesion. Blood Cells Mol Dis. 1997 Aug;23(2):292-301
  • Latest
    J:226422 Schleicher RI, et al., Platelets induce apoptosis via membrane-bound FasL. Blood. 2015 Sep 17;126(12):1483-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory