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Gp1ba
Gene Detail
 Symbol
Name
ID
Gp1ba
glycoprotein 1b, alpha polypeptide
MGI:1333744
Synonyms GPIba, GP Ib-alpha, GPIb-alpha
Feature Type protein coding gene
Genetic Map
Chromosome 11
43.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:70639144-70641820 bp, + strand
From VEGA annotation of GRCm38

  2677 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:143  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Gp1ba

Human
homologs
Human Homolog GP1BA, glycoprotein Ib (platelet), alpha polypeptide
NCBI Gene ID 2811
neXtProt AC  NX_P07359
Human Synonyms  BDPLT1, BDPLT3, BSS, CD42B, CD42b-alpha, DBPLT3, GP1B, GPIbA, VWDP
Human Chr (Location)  17p13.2; chr17:4932297-4935030 (+)  GRCh38
Disease Associations  (4) Diseases Associated with Human GP1BA
Alleles
and
phenotypes
All alleles(2) : Targeted(1) Chemically induced(1)
 
Homozygotes for a targeted null mutation exhibit prolonged bleeding times and reduced numbers of enlarged platelets. Heterozygotes have intermediate numbers of platelets.
 
Human Diseases Modeled Using Mouse Gp1ba (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process blood coagulation, cell adhesion, ...
Component anchored component of external side of plasma membrane, integral component of membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (2)    Tissues (2)   
Theiler Stages: 20
Assay TypeResults
RNA in situ 2
cDNA source data(1)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(6) Genomic(4) cDNA(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000006072 (Evidence)
Ensembl Gene ModelENSMUSG00000050675 (Evidence)
Entrez Gene14723 (Evidence)
UniGene377085
DFCITC1595033
DoTSDT.91588827
NIA Mouse Gene IndexU012858
PDB1K15
Consensus CDS ProjectCCDS24957.1
International Mouse Knockout Project StatusGp1ba
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006072 VEGA Gene Model | MGI Sequence Detail 2677 C57BL/6J ±  kb
transcript OTTMUST00000013696 VEGA | MGI Sequence Detail 2480 Not Applicable 
polypeptide OTTMUSP00000006354 VEGA | MGI Sequence Detail 734 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(6) UniProt(2)
Polymorphisms SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR001611 Leucine-rich repeat
InterPro IPR025875 Leucine rich repeat 4
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000001907 platelet glycoprotein Ib alpha chain
References (Earliest) J:49049 Ware J, et al., Cloning of the murine platelet glycoprotein Ibalpha gene highlighting species-specific platelet adhesion. Blood Cells Mol Dis. 1997 Aug;23(2):292-301
(Latest) J:205720 Hillgruber C, et al., Blocking von Willebrand factor for treatment of cutaneous inflammation. J Invest Dermatol. 2014 Jan;134(1):77-86
All references(49)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory