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Mpeg1 Gene Detail
Summary
  • Symbol
    Mpeg1
  • Name
    macrophage expressed gene 1
  • Synonyms
    Mpg-1, MPS1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333743
    NCBI Gene: 17476
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:12460779-12465284 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 8.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    102 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333743
protein coding gene Chr19:12460709-12465285 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024905
protein coding gene Chr19:9920521-9925026 (+)
A/J MGP_AJ_G0024881
protein coding gene Chr19:9297469-9301896 (+)
AKR/J MGP_AKRJ_G0024853
protein coding gene Chr19:9757939-9762441 (+)
BALB/cJ MGP_BALBcJ_G0024880
protein coding gene Chr19:9297096-9301524 (+)
C3H/HeJ MGP_C3HHeJ_G0024644
protein coding gene Chr19:9646436-9650937 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025329
protein coding gene Chr19:10464110-10468615 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022755
protein coding gene Chr19:9932922-9937350 (+)
CAST/EiJ MGP_CASTEiJ_G0024113
protein coding gene Chr19:9222066-9226494 (+)
CBA/J MGP_CBAJ_G0024618
protein coding gene Chr19:10546208-10550801 (+)
DBA/2J MGP_DBA2J_G0024750
protein coding gene Chr19:9334629-9339133 (+)
FVB/NJ MGP_FVBNJ_G0024713
protein coding gene Chr19:9359940-9364418 (+)
LP/J MGP_LPJ_G0024833
protein coding gene Chr19:9993105-9997607 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024740
protein coding gene Chr19:10327908-10332335 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025377
protein coding gene Chr19:9737279-9742347 (+)
PWK/PhJ MGP_PWKPhJ_G0023863
protein coding gene Chr19:8801093-8805516 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023666
protein coding gene Chr19:8873918-8878346 (+)
WSB/EiJ MGP_WSBEiJ_G0024181
protein coding gene Chr19:9598363-9602867 (+)



Homology
more
  • Human Ortholog
    MPEG1, macrophage expressed 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MPEG1, macrophage expressed 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Mpg-1, MPG1, MPS1
  • Links
    NCBI Gene ID: 219972
    neXtProt AC: NX_Q2M385
    UniProt: Q2M385

  • Chr Location
    11q12.1; chr11:59208510-59213021 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 2 genetic backgrounds
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased in susceptibility to infection induced morbidity/mortality induced by an isogenic cif::aadA or wild-type version of Y. pseudotuberculosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046805 Ensembl Gene Model | MGI Sequence Detail 4506 C57BL/6J ±  kb
transcript ENSMUST00000081035 Ensembl | MGI Sequence Detail 4335 Not Applicable  
polypeptide ENSMUSP00000108573 Ensembl | MGI Sequence Detail 720 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR039707 Macrophage-expressed gene 1 protein
    IPR020864 Membrane attack complex component/perforin (MACPF) domain
Molecular
Reagents
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  • All nucleic 80
    Genomic 1
    cDNA 78
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 30
    Developmental Gene Expression 6
    Gene Ontology 3
    Phenotypes 1
  • Earliest
    J:51737 Spilsbury K, et al., Isolation of a novel macrophage-specific gene by differential cDNA analysis. Blood. 1995 Mar 15;85(6):1620-9
  • Latest
    J:237787 Liu X, et al., Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. BMC Immunol. 2016 Aug 02;17(1):25

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory