Mpeg1 Gene Detail

Summary

• Symbol
  Mpeg1
• Name
  macrophage expressed gene 1
• Synonyms
  Mpg-1, MPS1

• Feature Type
  protein coding gene
• IDs
  MGI:1333743
  NCBI Gene: 17476

Location & Maps

• Sequence Map
  Chr19:12460779-12465284 bp, + strand
• From Ensembl annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    4506 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 19, 8.72 cM
• Mapping Data
  1 experiment

Homology

• Human Ortholog
  MPEG1, macrophage expressed 1

• Vertebrate Orthologs
  10

• Human Ortholog
  MPEG1, macrophage expressed 1
  Orthology source: HomoloGene, HGNC
• Synonyms
  Mpg-1, MPG1, MPS1
• Links
  HGNC:29619

  NCBI Gene ID: 219972

  neXtProt AC: NX_Q2M385

  UniProt: Q2M385

  
  
• Chr Location
  11q12.1; chr11:59208510-59213021 (-)  GRCh38.p7

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• HomoloGene
  Vertebrate Homology Class 11216
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;3 zebrafish
  
• HCOP
  human homology predictions: MPEG1
• Gene Tree
  Mpeg1
  

Mutations,
Alleles, and
Phenotypes

• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  26 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  2
• GO References
  1

• External Resources
  FuncBase

Expression

• Assay Results
  33
• Tissues
  3
• cDNA Data
  76
• Literature Summary
  3

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  ZFIN mpeg1.1, mpeg1.2

Interactions

• Mpeg1 interacts with 273 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

Sequences &
Gene Models

• All Sequences
  19
• RefSeq
  4
• UniProt
  3
• CCDS
  CCDS37926.1
• UniGene
  3999

• Ensembl
  ENSMUSG00000046805 (Evidence)
• NCBI Gene
  17476

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000046805	Ensembl Gene Model | MGI Sequence Detail	4506	C57BL/6J
transcript	ENSMUST00000081035	Ensembl | MGI Sequence Detail	4335	Not Applicable
polypeptide	ENSMUSP00000108573	Ensembl | MGI Sequence Detail	720	Not Applicable

Polymorphisms

• SNPs within 2kb
  102 from dbSNP Build 142

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000010533 macrophage-expressed gene 1 protein
  (term hierarchy)
• InterPro Domains
  IPR020864 Membrane attack complex component/perforin (MACPF) domain

Molecular
Reagents

• All nucleic 79

  Genomic 1

  cDNA 77

  Primer pair 1

  
  

  Microarray probesets 4

References

• Summaries
  All 24

  Developmental Gene Expression 3

  Gene Ontology 1
• Earliest
  J:51737 Spilsbury K, et al., Isolation of a novel macrophage-specific gene by differential cDNA analysis. Blood. 1995 Mar 15;85(6):1620-9
• Latest
  J:237787 Liu X, et al., Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. BMC Immunol. 2016 Aug 02;17(1):25