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Ran Gene Detail
Summary
  • Symbol
    Ran
  • Name
    RAN, member RAS oncogene family
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333112
    NCBI Gene: 19384
  • Gene Overview
    MyGene.info: RAN
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:129020156-129024322 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 67.99 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    41 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333112
protein coding gene Chr5:129020069-129024323 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030123
protein coding gene Chr5:133077215-133082297 (+)
A/J MGP_AJ_G0030090
protein coding gene Chr5:127483386-127489322 (+)
AKR/J MGP_AKRJ_G0030024
protein coding gene Chr5:131627589-131628175 (+)
BALB/cJ MGP_BALBcJ_G0030100
protein coding gene Chr5:128830535-128831121 (+)
C3H/HeJ MGP_C3HHeJ_G0029817
protein coding gene Chr5:132196229-132201223 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030553
protein coding gene Chr5:138180967-138189196 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027778
protein coding gene Chr5:121887494-121891763 (+)
CAST/EiJ MGP_CASTEiJ_G0029226
protein coding gene Chr5:131464037-131470647 (+)
CBA/J MGP_CBAJ_G0029787
protein coding gene Chr5:143548202-143553280 (+)
DBA/2J MGP_DBA2J_G0029937
protein coding gene Chr5:127469021-127469607 (+)
FVB/NJ MGP_FVBNJ_G0029893
protein coding gene Chr5:126533526-126537781 (+)
LP/J MGP_LPJ_G0030026
protein coding gene Chr5:133586611-133591764 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029924
protein coding gene Chr5:146939856-146944110 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030594
protein coding gene Chr5:131305842-131309925 (+)
PWK/PhJ MGP_PWKPhJ_G0028940
protein coding gene Chr5:126373745-126378680 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028777
protein coding gene Chr5:128874665-128878334 (+)
WSB/EiJ MGP_WSBEiJ_G0029300
protein coding gene Chr5:131959029-131962083 (+)



Homology
more
  • Human Ortholog
    RAN, RAN, member RAS oncogene family
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RAN, RAN, member RAS oncogene family
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARA24, Gsp1, TC4
  • Links
    NCBI Gene ID: 5901
    neXtProt AC: NX_P62826
    UniProt: P62826

  • Chr Location
    12q24.33; chr12:130871879-130877678 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotype references
  • All Mutations and Alleles
    38
  • Chemically induced (other)
    1
  • Gene trapped
    34
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Ran
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19384 NCBI Gene Model | MGI Sequence Detail 4167 C57BL/6J ±  kb
transcript NM_009391 RefSeq | MGI Sequence Detail 2288 C57BL/6  
polypeptide P62827 UniProt | EBI | MGI Sequence Detail 216 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR002041 Ran GTPase
    IPR001806 Small GTPase
    IPR005225 Small GTP-binding protein domain
Molecular
Reagents
less
  • All nucleic 24
    cDNA 23
    Other 1

    Microarray probesets 5
References
more
  • Summaries
    All 65
    Developmental Gene Expression 11
    Gene Ontology 11
    Phenotypes 12
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:255775 Connell M, et al., HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development. Elife. 2017 Oct 10;6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory