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Bnip3l Gene Detail
Summary
  • Symbol
    Bnip3l
  • Name
    BCL2/adenovirus E1B interacting protein 3-like
  • Synonyms
    D14Ertd719e, Nip3L, Nix
  • Feature Type
    protein coding gene
  • IDs
    MGI:1332659
    NCBI Gene: 12177
  • Gene Overview
    MyGene.info: BNIP3L
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:66985239-67008877 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 34.60 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    78 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1332659
protein coding gene Chr14:66985238-67008877 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021501
protein coding gene Chr14:61693741-61719592 (-)
A/J MGP_AJ_G0021460
protein coding gene Chr14:60198638-60225618 (-)
AKR/J MGP_AKRJ_G0021436
protein coding gene Chr14:62273317-62297364 (-)
BALB/cJ MGP_BALBcJ_G0021466
protein coding gene Chr14:60200487-60234572 (-)
C3H/HeJ MGP_C3HHeJ_G0021243
protein coding gene Chr14:62003992-62027548 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021905
protein coding gene Chr14:64506197-64535605 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019445
protein coding gene Chr14:58123547-58147199 (-)
CAST/EiJ MGP_CASTEiJ_G0020760
protein coding gene Chr14:58473277-58499991 (-)
CBA/J MGP_CBAJ_G0021210
protein coding gene Chr14:66489866-66519627 (-)
DBA/2J MGP_DBA2J_G0021333
protein coding gene Chr14:59854493-59878346 (-)
FVB/NJ MGP_FVBNJ_G0021312
protein coding gene Chr14:59257636-59283648 (-)
LP/J MGP_LPJ_G0021408
protein coding gene Chr14:62745926-62772174 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021341
protein coding gene Chr14:65506087-65530907 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021928
protein coding gene Chr14:61501384-61527488 (-)
PWK/PhJ MGP_PWKPhJ_G0020504
protein coding gene Chr14:56594420-56619319 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020337
protein coding gene Chr14:57459898-57489228 (-)
WSB/EiJ MGP_WSBEiJ_G0020813
protein coding gene Chr14:61820592-61850652 (-)



Homology
more
  • Human Ortholog
    BNIP3L, BCL2 interacting protein 3 like
  • Vertebrate Orthologs
    12
  • Human Ortholog
    BNIP3L, BCL2 interacting protein 3 like
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BNIP3a, NIX
  • Links
    NCBI Gene ID: 665
    neXtProt AC: NX_O60238
    UniProt: O60238

  • Chr Location
    8p21.2; chr8:26383007-26413128 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3195
    1 human;2 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: BNIP3L
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 4 alleles in 5 genetic backgrounds
    9 phenotypes from multigenic genotypes
    2 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit abnormal morphology, decreased numbers and increased fragility of reticulocyte and erythcrocyte.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022051 Ensembl Gene Model | MGI Sequence Detail 23639 C57BL/6J ±  kb
    transcript ENSMUST00000022634 Ensembl | MGI Sequence Detail 3238 Not Applicable  
    polypeptide ENSMUSP00000022634 Ensembl | MGI Sequence Detail 218 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 21
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1289182, MGI:2145873
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 10
      Gene Ontology 13
      Phenotypes 20
    • Earliest
      J:51799 Chen G, et al., Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. J Biol Chem. 1999 Jan 1;274(1):7-10
    • Latest
      J:247863 Hasmim M, et al., Cutting Edge: NANOG Activates Autophagy under Hypoxic Stress by Binding to BNIP3L Promoter. J Immunol. 2017 Feb 15;198(4):1423-1428

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory