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Bnip3l Gene Detail
Summary
  • Symbol
    Bnip3l
  • Name
    BCL2/adenovirus E1B interacting protein 3-like
  • Synonyms
    D14Ertd719e, Nip3L, Nix
  • Feature Type
    protein coding gene
  • IDs
    MGI:1332659
    NCBI Gene: 12177
  • Gene Overview
    MyGene.info: BNIP3L
Location & Maps
more
  • Sequence Map
    Chr14:66985239-67008877 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23639 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 34.60 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    BNIP3L, BCL2/adenovirus E1B 19kDa interacting protein 3-like
  • Vertebrate Orthologs
    12
  • Human Ortholog
    BNIP3L, BCL2/adenovirus E1B 19kDa interacting protein 3-like
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BNIP3a, NIX
  • Links
    NCBI Gene ID: 665
    neXtProt AC: NX_O60238

  • Chr Location
    8p21; chr8:26383007-26413129 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3195
    1 human;2 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: BNIP3L
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 4 alleles in 5 genetic backgrounds
    9 phenotypes from multigenic genotypes
    2 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    19
  • Chemically induced (other)
    1
  • Gene trapped
    13
  • Targeted
    5
  • Genomic Mutations
    1 involving Bnip3l
  • Incidental Mutations
Mice homozygous for a null allele exhibit abnormal morphology, decreased numbers and increased fragility of reticulocyte and erythcrocyte.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023686 VEGA Gene Model | MGI Sequence Detail 23639 C57BL/6J ±  kb
transcript OTTMUST00000057833 VEGA | MGI Sequence Detail 3238 Not Applicable  
polypeptide OTTMUSP00000027961 VEGA | MGI Sequence Detail 218 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    78 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000004782 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
  • InterPro Domains
    IPR010548 BNIP3
Molecular
Reagents
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  • All nucleic 22
    cDNA 20
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
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MGI:1289182, MGI:2145873
References
more
  • Summaries
    All 61
    Developmental Gene Expression 9
    Gene Ontology 12
    Phenotypes 19
  • Earliest
    J:51799 Chen G, et al., Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. J Biol Chem. 1999 Jan 1;274(1):7-10
  • Latest
    J:199612 Chen Y, et al., A nucleus-targeted alternately spliced Nix/Bnip3L protein isoform modifies nuclear factor kappaB (NFkappaB)-mediated cardiac transcription. J Biol Chem. 2013 May 31;288(22):15455-65

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory