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Bnip3l
Gene Detail
Symbol

Name
ID
Bnip3l
BCL2/adenovirus E1B interacting protein 3-like
MGI:1332659
Synonyms
D14Ertd719e, Nip3L, Nix
Feature Type
protein coding gene
Genetic Map
Chromosome 14
34.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:66985239-67008877 bp, - strand
From VEGA annotation of GRCm38

  23639 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3195  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Bnip3l

Human
homologs
Human Homolog BNIP3L, BCL2/adenovirus E1B 19kDa interacting protein 3-like
NCBI Gene ID 665
neXtProt AC  NX_O60238
Human Synonyms  BNIP3a, NIX
Human Chr (Location)  8p21; chr8:26383007-26413128 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(13) Targeted(5)
 
Mice homozygous for a null allele exhibit abnormal morphology, decreased numbers and increased fragility of reticulocyte and erythcrocyte.
 
Phenotype Images(2)
Interactions
Bnip3l interacts with 314 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process apoptotic process, defense response to virus, ...
Component cytosol, endoplasmic reticulum, ...
Function identical protein binding, lamin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (150)    Tissues (128)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 150
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) cDNA(20) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000023686 (Evidence)
Ensembl Gene ModelENSMUSG00000022051 (Evidence)
Entrez Gene12177 (Evidence)
DFCITC1573441
DoTSDT.110933282, DT.101388854, DT.495834, DT.87028763
NIA Mouse Gene IndexU158693, U128700
Consensus CDS ProjectCCDS27227.1
International Mouse Knockout Project StatusBnip3l
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023686 VEGA Gene Model | MGI Sequence Detail 23639 C57BL/6J ±  kb
transcript OTTMUST00000057833 VEGA | MGI Sequence Detail 3238 Not Applicable 
polypeptide OTTMUSP00000027961 VEGA | MGI Sequence Detail 218 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(78 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010548 BNIP3
Protein Ontology PR:000004782 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
References
(Earliest) J:51799 Chen G, et al., Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. J Biol Chem. 1999 Jan 1;274(1):7-10
(Latest) J:199612 Chen Y, et al., A nucleus-targeted alternately spliced Nix/Bnip3L protein isoform modifies nuclear factor kappaB (NFkappaB)-mediated cardiac transcription. J Biol Chem. 2013 May 31;288(22):15455-65
All references(62)
Other
accession IDs
MGI:1289182, MGI:2145873

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory