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Arhgap5 Gene Detail
Summary
  • Symbol
    Arhgap5
  • Name
    Rho GTPase activating protein 5
  • Synonyms
    p190B, p190-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1332637
    NCBI Gene: 11855
  • Gene Overview
    MyGene.info: ARHGAP5
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr12:52503972-52571975 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      68004 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 22.16 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ARHGAP5, Rho GTPase activating protein 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARHGAP5, Rho GTPase activating protein 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GFI2, p190-B, p190BRhoGAP, RhoGAP5
  • Links
    NCBI Gene ID: 394
    neXtProt AC: NX_Q13017
    UniProt: Q13017

  • Chr Location
    14q12; chr14:32076152-32159728 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 907
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ARHGAP5
  • Gene Tree
    Arhgap5
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes die at birth, are 30% smaller, do not inflate their lungs, and show a small thymus, abnormal adipocyte differentiation and brain defects in the corpus callosum, anterior commissure and lateral ventricles. Mutant MEFs show impaired adipogenesis but undergo myogenesis in response to IGF-1.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    196
  • Tissues
    125
  • cDNA Data
    13
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035133 Ensembl Gene Model | MGI Sequence Detail 68004 C57BL/6J ±  kb
    transcript ENSMUST00000110725 Ensembl | MGI Sequence Detail 5197 Not Applicable  
    polypeptide ENSMUSP00000106353 Ensembl | MGI Sequence Detail 1503 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      417 from dbSNP Build 142
    • RFLP
      1
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR002713 FF domain
      IPR036517 FF domain superfamily
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR000198 Rho GTPase-activating protein domain
      IPR032835 Rho GTPase-activating protein, FF domain
      IPR039007 Rho GTPase-activating protein, pG1 domain
      IPR039006 Rho GTPase-activating protein, pG2 domain
      IPR008936 Rho GTPase activation protein
      IPR001806 Small GTPase
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 3
      cDNA 13
      Primer pair 1
      Other 2

      Microarray probesets 8
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 10
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:24667 Webster LT, Inherited and acquired factors in resistance to infection. I. Development of resistant and susceptible lines of mice through selective breeding. J Exp Med. 1933;57:793-843
    • Latest
      J:229358 Teo ZL, et al., Integrin linked kinase (ILK) is required for lens epithelial cell survival, proliferation and differentiation. Exp Eye Res. 2014 Apr;121:130-42
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/09/2018
    MGI 6.12     		The Jackson Laboratory