Arhgap5 MGI Mouse Gene Detail - MGI:1332637 - Rho GTPase activating protein 5

Arhgap5 Gene Detail

Symbol

Arhgap5
Name

Rho GTPase activating protein 5
Synonyms

p190B, p190-B

Feature Type

protein coding gene
IDs

MGI:1332637
NCBI Gene: 11855
Gene Overview

MyGene.info: ARHGAP5

Sequence Map

Chr12:52516077-52567852 bp, + strand
From Ensembl annotation of GRCm38

Mouse Genome Browser
Download
Sequence

51776 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 22.16 cM
Mapping Data

2 experiments

Human Ortholog

ARHGAP5, Rho GTPase activating protein 5

Vertebrate Orthologs

10

Human Ortholog

ARHGAP5, Rho GTPase activating protein 5
Orthology source: HomoloGene, HGNC
Synonyms

GFI2, p190-B, p190BRhoGAP, RhoGAP5
Links

HGNC:675

NCBI Gene ID: 394

neXtProt AC: NX_Q13017

UniProt: Q13017
Chr Location

14q12; chr14:32076152-32159728 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 907
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: ARHGAP5
Gene Tree

Arhgap5

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Phenotype Summary

12 phenotypes from 1 allele in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Gene trapped

3
Targeted

1
Genomic Mutations

1 involving Arhgap5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available

Homozygotes die at birth, are 30% smaller, do not inflate their lungs, and show a small thymus, abnormal adipocyte differentiation and brain defects in the corpus callosum, anterior commissure and lateral ventricles. Mutant MEFs show impaired adipogenesis but undergo myogenesis in response to IGF-1.

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All GO Annotations

13
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

196
Tissues

125
cDNA Data

13
Literature Summary

10

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Arhgap5 interacts with 244 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

39
RefSeq

10
UniProt

5
CCDS

CCDS36443.1

Ensembl

ENSMUSG00000035133 (Evidence)
NCBI Gene

11855

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035133	Ensembl Gene Model \| MGI Sequence Detail	51776	C57BL/6J	± kb
transcript	ENSMUST00000110725	Ensembl \| MGI Sequence Detail	5197	Not Applicable
polypeptide	ENSMUSP00000106353	Ensembl \| MGI Sequence Detail	1503	Not Applicable

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SNPs within 2kb

402 from dbSNP Build 142

RFLP

1

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UniProt

5 Sequences
Protein Ontology

PR:000004238 rho GTPase-activating protein 5

(term hierarchy)
InterPro Domains

IPR002713 FF domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR000198 Rho GTPase-activating protein domain

IPR032835 Rho GTPase-activating protein, FF domain

IPR008936 Rho GTPase activation protein

IPR001806 Small GTPase superfamily

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All nucleic 18

Genomic 3

cDNA 13

Primer pair 1

Other 1

Microarray probesets 8

Summaries

All 39

Developmental Gene Expression 10

Gene Ontology 6

Phenotypes 12
Earliest

J:24667 Webster LT, Inherited and acquired factors in resistance to infection. I. Development of resistant and susceptible lines of mice through selective breeding. J Exp Med. 1933;57:793-843
Latest

J:229358 Teo ZL, et al., Integrin linked kinase (ILK) is required for lens epithelial cell survival, proliferation and differentiation. Exp Eye Res. 2014 Apr;121:130-42

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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