Arhgap5 MGI Mouse Gene Detail - MGI:1332637 - Rho GTPase activating protein 5

Symbol

Arhgap5
Name

Rho GTPase activating protein 5
Synonyms

p190B, p190-B

Feature Type

protein coding gene
IDs

MGI:1332637
NCBI Gene: 11855
Gene Overview

MyGene.info: ARHGAP5
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr12:52503972-52571975 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 22.16 cM
Mapping Data

2 experiments

SNPs within 2kb

417 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1332637	protein coding gene	Chr12:52503771-52571978 (.)
129S1/SvImJ	MGP_129S1SvImJ_G0019732	protein coding gene	Chr12:51330752-51399137 (+)
A/J	MGP_AJ_G0019694	protein coding gene	Chr12:49519650-49582909 (+)
AKR/J	MGP_AKRJ_G0019665	protein coding gene	Chr12:51009736-51073861 (+)
BALB/cJ	MGP_BALBcJ_G0019672	protein coding gene	Chr12:49793253-49861743 (+)
C3H/HeJ	MGP_C3HHeJ_G0019475	protein coding gene	Chr12:51118616-51182142 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020120	protein coding gene	Chr12:52931377-52995900 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017743	protein coding gene	Chr12:47888613-47954995 (+)
CAST/EiJ	MGP_CASTEiJ_G0019028	protein coding gene	Chr12:46156566-46228669 (+)
CBA/J	MGP_CBAJ_G0019447	protein coding gene	Chr12:54719281-54802367 (+)
DBA/2J	MGP_DBA2J_G0019561	protein coding gene	Chr12:49389289-49452757 (+)
FVB/NJ	MGP_FVBNJ_G0019550	protein coding gene	Chr12:48823135-48890687 (+)
LP/J	MGP_LPJ_G0019633	protein coding gene	Chr12:51373595-51442210 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019586	protein coding gene	Chr12:56371252-56447992 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020158	protein coding gene	Chr12:50519123-50587015 (+)
PWK/PhJ	MGP_PWKPhJ_G0018795	protein coding gene	Chr12:43968972-44036993 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018589	protein coding gene	Chr12:45098091-45160211 (+)
WSB/EiJ	MGP_WSBEiJ_G0019079	protein coding gene	Chr12:50997704-51064286 (+)

Human Ortholog

ARHGAP5, Rho GTPase activating protein 5

Vertebrate Orthologs

10

Human Ortholog

ARHGAP5, Rho GTPase activating protein 5
Orthology source: HomoloGene, HGNC
Synonyms

GFI2, p190-B, p190BRhoGAP, RhoGAP5
Links

HGNC:675

NCBI Gene ID: 394

neXtProt AC: NX_Q13017

UniProt: Q13017
Chr Location

14q12; chr14:32076152-32159728 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 907
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: ARHGAP5
Gene Tree

Arhgap5

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Phenotype Summary

12 phenotypes from 1 allele in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Gene trapped

3
Targeted

1
Genomic Mutations

1 involving Arhgap5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes die at birth, are 30% smaller, do not inflate their lungs, and show a small thymus, abnormal adipocyte differentiation and brain defects in the corpus callosum, anterior commissure and lateral ventricles. Mutant MEFs show impaired adipogenesis but undergo myogenesis in response to IGF-1.

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All GO Annotations

20
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

196
Tissues

125
cDNA Data

13
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase arhgap5

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Arhgap5 interacts with 244 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

63
RefSeq

10
UniProt

6
CCDS

CCDS36443.1

Ensembl

ENSMUSG00000035133 (Evidence)
NCBI Gene

11855

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035133	Ensembl Gene Model \| MGI Sequence Detail	68004	C57BL/6J	± kb
transcript	ENSMUST00000110725	Ensembl \| MGI Sequence Detail	5197	Not Applicable
polypeptide	ENSMUSP00000106353	Ensembl \| MGI Sequence Detail	1503	Not Applicable

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UniProt

6 Sequences
InterPro Domains

IPR002713 FF domain

IPR036517 FF domain superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR000198 Rho GTPase-activating protein domain

IPR032835 Rho GTPase-activating protein, FF domain

IPR039007 Rho GTPase-activating protein, pG1 domain

IPR039006 Rho GTPase-activating protein, pG2 domain

IPR008936 Rho GTPase activation protein

IPR001806 Small GTPase

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All nucleic 19

Genomic 3

cDNA 13

Primer pair 1

Other 2

Microarray probesets 8

Summaries

All 44

Developmental Gene Expression 10

Gene Ontology 8

Phenotypes 13
Earliest

J:24667 Webster LT, Inherited and acquired factors in resistance to infection. I. Development of resistant and susceptible lines of mice through selective breeding. J Exp Med. 1933;57:793-843
Latest

J:244207 Hinge A, et al., p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation. Nat Commun. 2017 Feb 08;8:14382

TSS for Arhgap5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113433	Chr12:52503753-52503786 (+)	-202 bp
Tssr113434	Chr12:52503923-52503949 (+)	-36 bp
Tssr113435	Chr12:52503992-52504028 (+)	38 bp
Tssr113436	Chr12:52504035-52504051 (+)	71 bp
Tssr113437	Chr12:52504063-52504093 (+)	106 bp
Tssr113438	Chr12:52504097-52504114 (+)	134 bp
Tssr113439	Chr12:52504246-52504285 (+)	294 bp
Tssr3839	Chr12:52504309-52504318 (+)	342 bp
Tssr113442	Chr12:52516266-52516281 (+)	12,302 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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