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Ugcg
Gene Detail
Symbol

Name
ID
Ugcg
UDP-glucose ceramide glucosyltransferase
MGI:1332243
Synonyms
Epcs21, GlcT-1, Ugcgl
Feature Type
protein coding gene
Genetic Map
Chromosome 4
32.44 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:59189257-59222833 bp, + strand
From VEGA annotation of GRCm38

  33577 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37763  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: UGCG
Gene Tree: Ugcg

Human
homologs
UGCG, UDP-glucose ceramide glucosyltransferase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7357
neXtProt AC: NX_Q16739

Human Synonyms: GCS, GLCT1

Human Chr (Location): 9q31; chr9:111896766-111935374 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(7) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
At embryonic day 7.5, embryos homozygous for a null mutation exhibit decreased size, markedly reduced extraembryonic tissues and a large increase in cells undergoing apoptosis. Mutants die by embryonic day 8.5.
 
Interactions
Ugcg interacts with 367 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (110)    Tissues (109)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
In situ reporter (knock in) 9
RT-PCR 7
cDNA source data(107)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ugcg    NEW 
Molecular
reagents
All nucleic(111) Genomic(2) cDNA(107) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000007645 (Evidence)
Ensembl Gene Model ENSMUSG00000028381 (Evidence)
Entrez Gene 22234 (Evidence)
UniGene 198803
DFCI TC1574414
DoTS DT.101407788, DT.91422495, DT.94336815, DT.97399586
NIA Mouse Gene Index U004376
EC 2.4.1.80
Consensus CDS Project CCDS18219.1
International Mouse Phenotyping Consortium Status Ugcg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007645 VEGA Gene Model | MGI Sequence Detail 33577 C57BL/6J ±  kb
transcript OTTMUST00000017544 VEGA | MGI Sequence Detail 4012 Not Applicable 
polypeptide OTTMUSP00000008102 VEGA | MGI Sequence Detail 394 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(4) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(125 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025993 Ceramide glucosyltransferase
Protein Ontology PR:000017043 ceramide glucosyltransferase
References
(Earliest) J:48204 Ichikawa S, et al., Molecular cloning and expression of mouse ceramide glucosyltransferase. Biochem Mol Biol Int. 1998 May;44(6):1193-202
(Latest) J:216600 Lau CG, et al., Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil. Mol Reprod Dev. 2014 Nov;81(11):994-1008
All references(56)
Other
accession IDs
MGI:1860296, MGI:2140489, MGI:2140685

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory