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Ugcg Gene Detail
Summary
  • Symbol
    Ugcg
  • Name
    UDP-glucose ceramide glucosyltransferase
  • Synonyms
    Epcs21, GlcT-1, Ugcgl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1332243
    NCBI Gene: 22234
  • Gene Overview
    MyGene.info: UGCG
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:59189257-59222833 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      33577 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 32.44 cM, cytoband B3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    UGCG, UDP-glucose ceramide glucosyltransferase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UGCG, UDP-glucose ceramide glucosyltransferase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GCS, GLCT1
  • Links
    NCBI Gene ID: 7357
    neXtProt AC: NX_Q16739
    UniProt: Q16739

  • Chr Location
    9q31.3; chr9:111896766-111935374 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 37763
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: UGCG
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 5 alleles in 5 genetic backgrounds
    9 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
At embryonic day 7.5, embryos homozygous for a null mutation exhibit decreased size, markedly reduced extraembryonic tissues and a large increase in cells undergoing apoptosis. Mutants die by embryonic day 8.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000007645 VEGA Gene Model | MGI Sequence Detail 33577 C57BL/6J ±  kb
    transcript OTTMUST00000017544 VEGA | MGI Sequence Detail 4012 Not Applicable  
    polypeptide OTTMUSP00000008102 VEGA | MGI Sequence Detail 394 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      124 from dbSNP Build 142
    • RFLP
    Protein
    Information
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    Molecular
    Reagents
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    • All nucleic 112
      Genomic 2
      cDNA 108
      Primer pair 1
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
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    MGI:1860296, MGI:2140489, MGI:2140685
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 8
      Gene Ontology 4
      Phenotypes 19
    • Earliest
      J:48204 Ichikawa S, et al., Molecular cloning and expression of mouse ceramide glucosyltransferase. Biochem Mol Biol Int. 1998 May;44(6):1193-202
    • Latest
      J:255485 Li S, et al., Transcription Factor CTIP1/ BCL11A Regulates Epidermal Differentiation and Lipid Metabolism During Skin Development. Sci Rep. 2017 Oct 18;7(1):13427

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory