About   Help   FAQ
Cds2 Gene Detail
Summary
  • Symbol
    Cds2
  • Name
    CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
  • Synonyms
    5730450N06Rik, 5730460C18Rik, D2Wsu127e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1332236
    NCBI Gene: 110911
  • Gene Overview
    MyGene.info: CDS2
Location & Maps
more
  • Sequence Map
    Chr2:132263148-132312050 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      48903 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 64.15 cM, cytoband G1
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    CDS2, CDP-diacylglycerol synthase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CDS2, CDP-diacylglycerol synthase 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 8760
    neXtProt AC: NX_O95674

  • Chr Location
    20p12.3; chr20:5126761-5197887 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    136
  • Chemically induced (other)
    1
  • Gene trapped
    132
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Cds2
  • Incidental Mutations
Mice homozygous for disruptions in this gene display a lethal phenotype. Heterozygotes show a distorted lymphocyte distribution and enhanced sensorimotor gating.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015552 VEGA Gene Model | MGI Sequence Detail 48903 C57BL/6J ±  kb
transcript OTTMUST00000036944 VEGA | MGI Sequence Detail 8396 Not Applicable  
polypeptide OTTMUSP00000016575 VEGA | MGI Sequence Detail 444 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    472 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 159
    cDNA 158
    Primer pair 1

    Microarray probesets 9
Other
Accession IDs
less
MGD-MRK-35819, MGI:107353, MGI:1917815, MGI:1924099, MGI:2139105
References
more
  • Summaries
    All 43
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/29/2016
MGI 6.06
The Jackson Laboratory