Cds2
Gene Detail

Symbol Name ID

Cds2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 MGI:1332236

Synonyms

5730450N06Rik, 5730460C18Rik, D2Wsu127e

Feature Type

protein coding gene

Genetic Map

Chromosome 2

64.15 cM, cytoband G1
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr2:132263148-132312050 bp, + strand From VEGA annotation of GRCm38   48903 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Cds2 ± 2 cM)

Protein SuperFamily: phosphatidate cytidylyltransferase, eukaryotic type
Gene Tree: Cds2

Human ortholog

CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 NCBI Gene ID 8760
Human Chr20:5107482-5171989 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(134) : Targeted(2) Gene trapped(132)
 

Mice homozygous for disruptions in this gene display a lethal phenotype. Heterozygotes show a distorted lymphocyte distribution and enhanced sensorimotor gating.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	glycosylation, lipid metabolic process, ...
Component	endoplasmic reticulum, integral to membrane, ...
Function	nucleotidyltransferase activity, phosphatidate cytidylyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (170)    Tissues (143)    Images (14)
Theiler Stages: 11, 19, 22, 23, 28

Assay Type	Results
RNA in situ	157
Northern blot	7
RT-PCR	6

cDNA source data(154)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(155) cDNA(154) Primer pair(1)
Microarray probesets(9)

Other database links

VEGA Gene Model	OTTMUSG00000015552 (Evidence)
Ensembl Gene Model	ENSMUSG00000058793 (Evidence)
Entrez Gene	110911 (Evidence)
UniGene	284503
DFCI	TC1575805, TC1589501, TC1671368
DoTS	DT.101360935, DT.101722865, DT.103576033, DT.530989, DT.97391403
NIA Mouse Gene Index	U002502
EC	2.7.7.41
Consensus CDS Project	CCDS16772.1
International Mouse Knockout Project Status	Cds2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015552	VEGA Gene Model | MGI Sequence Detail	48903	C57BL/6J
transcript	OTTMUST00000036944	VEGA | MGI Sequence Detail	8396	Not Applicable
polypeptide	OTTMUSP00000016575	VEGA | MGI Sequence Detail	444	Not Applicable

All sequences(70) RefSeq(2) UniProt(8)

Polymorphisms

SNPs(310 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000374	Phosphatidate cytidylyltransferase
InterPro	IPR016720	Phosphatidate cytidylyltransferase, eukaryota
Protein Ontology	PR:000005291	phosphatidate cytidylyltransferase 2

References

(Earliest) J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(45)

Other accession IDs

MGD-MRK-35819, MGI:107353, MGI:1917815, MGI:1924099, MGI:2139105