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Zfp148 Gene Detail
Summary
  • Symbol
    Zfp148
  • Name
    zinc finger protein 148
  • Synonyms
    2210405J08Rik, BERF-1, beta enolase repressor factor 1, BFCOL1, ZBP-89
  • Feature Type
    protein coding gene
  • IDs
    MGI:1332234
    NCBI Gene: 22661
  • Gene Overview
    MyGene.info: ZNF148
Location & Maps
more
  • Sequence Map
    Chr16:33380775-33503903 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      123129 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 23.93 cM
  • Mapping Data
    3 experiments
Homology
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  • Human Ortholog
    ZNF148, zinc finger protein 148
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZNF148, zinc finger protein 148
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BERF-1, BFCOL1, HT-BETA, pHZ-52, ZBP-89, ZFP148
  • Links
    NCBI Gene ID: 7707
    neXtProt AC: NX_Q9UQR1

  • Chr Location
    3q21; chr3:125225669-125375354 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8003
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: ZNF148
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 5 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Disruption of one allele results in haploinsufficient male infertility in which chimeric males display a loss of germ cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 22661 NCBI Gene Model | MGI Sequence Detail 123129 C57BL/6J ±  kb
transcript NM_011749 RefSeq | MGI Sequence Detail 9431 C57BL/6  
polypeptide Q61624 UniProt | EBI | MGI Sequence Detail 794 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    532 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000017718 zinc finger protein 148
  • InterPro Domains
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 172
    cDNA 168
    Primer pair 4

    Microarray probesets 12
Other
Accession IDs
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MGI:1925897, MGI:2146444, MGI:2146606
References
more
  • Summaries
    All 56
    Developmental Gene Expression 10
    Gene Ontology 6
    Phenotypes 21
  • Earliest
    J:38556 Hasegawa T, et al., Cloning and characterization of a transcription factor that binds to the proximal promoters of the two mouse type I collagen genes. J Biol Chem. 1997 Feb 21;272(8):4915-23
  • Latest
    J:226877 Sayin VI, et al., Loss of one copy of Zfp148 reduces lesional macrophage proliferation and atherosclerosis in mice by activating p53. Circ Res. 2014 Oct 10;115(9):781-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory