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Lin7b Gene Detail
Summary
  • Symbol
    Lin7b
  • Name
    lin-7 homolog B (C. elegans)
  • Synonyms
    LIN-7B, MALS-2, Veli2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330858
    NCBI Gene: 22342
  • Gene Overview
    MyGene.info: LIN7B
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45367891-45370564 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.28 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    27 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330858
protein coding gene Chr7:45367891-45370583 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032216
protein coding gene Chr7:45617462-45620154 (-)
A/J MGP_AJ_G0032195
protein coding gene Chr7:44753740-44756432 (-)
AKR/J MGP_AKRJ_G0032131
protein coding gene Chr7:45983176-45985868 (-)
BALB/cJ MGP_BALBcJ_G0032207
protein coding gene Chr7:44742356-44745048 (-)
C3H/HeJ MGP_C3HHeJ_G0031923
protein coding gene Chr7:46473463-46476155 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032699
protein coding gene Chr7:47885693-47888385 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029713
protein coding gene Chr7:47305431-47308119 (-)
CAST/EiJ MGP_CASTEiJ_G0031251
protein coding gene Chr7:37878331-37881020 (-)
CBA/J MGP_CBAJ_G0031887
protein coding gene Chr7:49465729-49468421 (-)
DBA/2J MGP_DBA2J_G0032045
protein coding gene Chr7:44416815-44419507 (-)
FVB/NJ MGP_FVBNJ_G0031996
protein coding gene Chr7:44195954-44198646 (-)
LP/J MGP_LPJ_G0032123
protein coding gene Chr7:46321957-46324650 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032033
protein coding gene Chr7:48171109-48173801 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032715
protein coding gene Chr7:45200157-45202852 (-)
PWK/PhJ MGP_PWKPhJ_G0030974
protein coding gene Chr7:37789805-37792495 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030811
protein coding gene Chr7:33209562-33212256 (-)
WSB/EiJ MGP_WSBEiJ_G0031368
protein coding gene Chr7:45694853-45697547 (-)



Homology
more
  • Human Ortholog
    LIN7B, lin-7 homolog B, crumbs cell polarity complex component
  • Vertebrate Orthologs
    8
  • Human Ortholog
    LIN7B, lin-7 homolog B, crumbs cell polarity complex component
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LIN-7B, MALS2, MALS-2, VELI2
  • Links
    NCBI Gene ID: 64130
    neXtProt AC: NX_Q9HAP6
    UniProt: Q9HAP6

  • Chr Location
    19q13.33; chr19:49114339-49118460 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    5 phenotype references
Mice homozygous for disruptions in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 22342 NCBI Gene Model | MGI Sequence Detail 2674 C57BL/6J ±  kb
transcript NM_011698 RefSeq | MGI Sequence Detail 746 Not Specified  
polypeptide O88951 UniProt | EBI | MGI Sequence Detail 207 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 6
References
more
  • Summaries
    All 34
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 5
  • Earliest
    J:49850 Butz S, et al., A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Cell. 1998 Sep 18;94(6):773-82
  • Latest
    J:212850 Karataeva AR, et al., C-terminal interactors of the AMPA receptor auxiliary subunit Shisa9. PLoS One. 2014;9(2):e87360

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory