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Lin7c
Gene Detail
Symbol

Name
ID
Lin7c
lin-7 homolog C (C. elegans)
MGI:1330839
Synonyms
9130007B12Rik, D2Ertd520e, Lin7c, LIN-7C, LIN-7-C, MALS-3, Veli3
Feature Type
protein coding gene
Genetic Map
Chromosome 2
56.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:109890853-109901003 bp, + strand
From VEGA annotation of GRCm38

  10151 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22649  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Lin-7 homolog
Gene Tree: Lin7c

Human
homologs
Human Homolog LIN7C, lin-7 homolog C (C. elegans)
NCBI Gene ID 55327
neXtProt AC  NX_Q9NUP9
Human Synonyms  LIN-7C, LIN-7-C, MALS3, MALS-3, VELI3
Human Chr (Location)  11p14; chr11:27494418-27506779 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted disruption of this gene appears to have no phenotype, but when combined with Lin7a or Lin7a and Lin7b results in early postnatal lethality.
 
Phenotype Images(4)
Interactions
Lin7c interacts with 381 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process exocytosis, morphogenesis of an epithelial sheet, ...
Component cell, cell-cell junction, ...
Function cytoskeletal protein binding, L27 domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (17)    Tissues (9)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 17
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(23) Primer pair(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000015123 (Evidence)
Ensembl Gene ModelENSMUSG00000027162 (Evidence)
Entrez Gene22343 (Evidence)
DFCITC1576211, TC1578971, TC1597104
DoTSDT.101385400, DT.532997, DT.91592058
NIA Mouse Gene IndexU002220
Consensus CDS ProjectCCDS16509.1
International Mouse Knockout Project StatusLin7c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015123 VEGA Gene Model | MGI Sequence Detail 10151 C57BL/6J ±  kb
transcript OTTMUST00000035872 VEGA | MGI Sequence Detail 4228 Not Applicable 
polypeptide OTTMUSP00000016097 VEGA | MGI Sequence Detail 197 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(68 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004172 L27
InterPro IPR014775 L27, C-terminal
InterPro IPR017365 Lin-7 homologue
InterPro IPR001478 PDZ domain
Protein Ontology PR:000009827 protein lin-7 homolog C
References
(Earliest) J:49850 Butz S, et al., A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Cell. 1998 Sep 18;94(6):773-82
(Latest) J:209053 Hoekstra EJ, et al., Lmx1a is an activator of Rgs4 and Grb10 and is responsible for the correct specification of rostral and medial mdDA neurons. Eur J Neurosci. 2013 Jan;37(1):23-32
All references(52)
Other
accession IDs
MGI:1261877, MGI:1918822, MGI:2138876, MGI:2139174, MGI:2139318

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory