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Cdk5r2 Gene Detail
Summary
  • Symbol
    Cdk5r2
  • Name
    cyclin dependent kinase 5, regulatory subunit 2
  • Synonyms
    B230310J22Rik, p39
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330828
    NCBI Gene: 12570
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:74894188-74896891 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 38.54 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    93 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330828
 protein coding gene Chr1:74894093-74896891 (+)
129S1/SvImJ ENSMUSG00200034094
 protein coding gene Chr1:72554154-72556952 (+)
A/J ENSMUSG00195010077
 protein coding gene Chr1:71978968-71981767 (+)
AKR/J ENSMUSG00220010194
 protein coding gene Chr1:72124118-72126916 (+)
BALB/cJ ENSMUSG00180015817
 protein coding gene Chr1:72240846-72243644 (+)
C3H/HeJ ENSMUSG00175016542
 protein coding gene Chr1:72379326-72382124 (+)
C57BL/6NJ ENSMUSG00215021490
 protein coding gene Chr1:72286174-72288972 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014276
 protein coding gene Chr1:68403637-68406431 (+)
CAST/EiJ ENSTCUG00005027597
 protein coding gene Chr1:72002037-72004835 (+)
CBA/J ENSMUSG00210039339
 protein coding gene Chr1:72063063-72065861 (+)
DBA/2J ENSMUSG00185031256
 protein coding gene Chr1:73157506-73160304 (+)
FVB/NJ ENSMUSG00205033987
 protein coding gene Chr1:71735778-71738576 (+)
JF1/MsJ ENSUMUG00000005657
 protein coding gene Chr1:72052850-72055648 (+)
LP/J ENSMUSG00230013243
 protein coding gene Chr1:73147281-73150079 (+)
NOD/ShiLtJ ENSMUSG00190025153
 protein coding gene Chr1:72289252-72292050 (+)
NZO/HlLtJ ENSMUSG00225039236
 protein coding gene Chr1:76362413-76365211 (+)
PWK/PhJ ENSLUMG00010011773
 protein coding gene Chr1:71634808-71637606 (+)
SPRET/EiJ ENSMSPG00010016196
 protein coding gene Chr1:73725595-73728387 (+)
WSB/EiJ ENSIUOG00005012862
 protein coding gene Chr1:71910792-71913590 (+)



Homology
more
  • Human Ortholog
    CDK5R2, cyclin dependent kinase 5 regulatory subunit 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDK5R2, cyclin dependent kinase 5 regulatory subunit 2
  • Synonyms
    NCK5AI, P39, p39nck5ai
  • Links
    NCBI Gene ID: 8941
    UniProt: Q13319

  • Chr Location
    2q35; chr2:218959666-218962155 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    22 phenotypes from multigenic genotypes
    21 phenotype references
Homozygous mutation of this gene does not appear to result in a phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    671
  • Tissues
    27
  • cDNA Data
    7
  • Literature Summary
    11
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 12570 NCBI Gene Model | MGI Sequence Detail 2704 C57BL/6J ±  kb
transcript NM_009872 RefSeq | MGI Sequence Detail 2704 Not Specified  
polypeptide O35926 UniProt | EBI | MGI Sequence Detail 369 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    Genomic 1
    cDNA 8
    Other 3
    Antibodies 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:3528161
References
more
  • Summaries
    All 63
    Developmental Gene Expression 11
    Gene Ontology 12
    Phenotypes 21
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:338083 Hwang I, et al., Cerebellar dysfunction and schizophrenia-like behavior in Ebp1-deficient mice. Mol Psychiatry. 2022 Apr;27(4):2030-2041
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory