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Osmr
Gene Detail
Symbol

Name
ID
Osmr
oncostatin M receptor
MGI:1330819
Synonyms
OSMRB
Feature Type
protein coding gene
Genetic Map
Chromosome 15
3.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:6813577-6874969 bp, - strand
From VEGA annotation of GRCm38

  61393 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2972  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: OSMR
Gene Tree: Osmr

Human
homologs
OSMR, oncostatin M receptor
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9180
neXtProt AC: NX_Q99650

Human Synonyms: OSMRB, PLCA1

Human Chr (Location): 5p13.1; chr5:38845858-38945579 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human OSMR

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(3) Transposon induced(1)
Genomic Mutations involving Osmr (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit anemia, decreased hematocrit, and reduced erythroid progenitor, erythrocyte, platelet, and megakaryocyte cells. Homozygotes also show increased susceptibility to diet-induced obesity.
 
Interactions
Osmr interacts with 285 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (61)    Tissues (45)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 40
RT-PCR 21
cDNA source data(49)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase osmr ; ZFIN osmr    NEW 
Molecular
reagents
All nucleic(55) Genomic(1) cDNA(51) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000040092 (Evidence)
Ensembl Gene Model ENSMUSG00000022146 (Evidence)
Entrez Gene 18414 (Evidence)
UniGene 10760
DFCI TC1610781, TC1580811
DoTS DT.91330178, DT.487678
NIA Mouse Gene Index U035985
Consensus CDS Project CCDS27368.1
International Mouse Phenotyping Consortium Status Osmr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040092 VEGA Gene Model | MGI Sequence Detail 61393 C57BL/6J ±  kb
transcript OTTMUST00000104138 VEGA | MGI Sequence Detail 5491 Not Applicable 
polypeptide OTTMUSP00000058250 VEGA | MGI Sequence Detail 971 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(10) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(588 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003529 Long hematopoietin receptor, Gp130 family 2, conserved site
Protein Ontology PR:000012060 oncostatin-M-specific receptor subunit beta
References
(Earliest) J:47670 Lindberg RA, et al., Cloning and characterization of a specific receptor for mouse oncostatin M. Mol Cell Biol. 1998 Jun;18(6):3357-67
(Latest) J:221341 Lun MP, et al., Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production. J Neurosci. 2015 Mar 25;35(12):4903-16
All references(48)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory