Osmr
Gene Detail

Symbol Name ID

Osmr oncostatin M receptor MGI:1330819

Synonyms

OSMRB

Feature Type

protein coding gene

Genetic Map

Chromosome 15

3.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr15:6813577-6874969 bp, - strand From VEGA annotation of GRCm38   61393 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Osmr ± 2 cM)

Gene Tree: Osmr

Human ortholog

OSMR oncostatin M receptor NCBI Gene ID 9180
Human Synonyms: OSMRB, PLCA1
Human Chr5:38845960-38935743 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human OSMR (1)

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a knock-out allele exhibit anemia, decreased hematocrit, and reduced erythroid progenitor, erythrocyte, platelet, and megakaryocyte cells.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	cell surface receptor signaling pathway, oncostatin-M-mediated signaling pathway, ...
Component	integral to membrane, integral to plasma membrane, ...
Function	cytokine receptor activity, growth factor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (62)    Tissues (41)    Images (20)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	41
RT-PCR	21

cDNA source data(49)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(55) Genomic(1) cDNA(51) Primer pair(3)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000040092 (Evidence)
Ensembl Gene Model	ENSMUSG00000022146 (Evidence)
Entrez Gene	18414 (Evidence)
UniGene	10760
DFCI	TC1580811, TC1610781
DoTS	DT.487678, DT.91330178
NIA Mouse Gene Index	U035985
Consensus CDS Project	CCDS27368.1
International Mouse Knockout Project Status	Osmr

Sequences

Length	Strain/Species
genomic	OTTMUSG00000040092	VEGA Gene Model | MGI Sequence Detail	61393	C57BL/6J
transcript	OTTMUST00000104138	VEGA | MGI Sequence Detail	5491	Not Applicable
polypeptide	OTTMUSP00000058250	VEGA | MGI Sequence Detail	971	Not Applicable

All sequences(36) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(431 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003529	Long hematopoietin receptor, Gp130 family 2, conserved site
Protein Ontology	PR:000012060	oncostatin-M-specific receptor subunit beta

References

(Earliest) J:47670 Lindberg RA, et al., Cloning and characterization of a specific receptor for mouse oncostatin M. Mol Cell Biol. 1998 Jun;18(6):3357-67
(Latest) J:183317 Hughes K, et al., Conditional deletion of Stat3 in mammary epithelium impairs the acute phase response and modulates immune cell numbers during post-lactational regression. J Pathol. 2012 May;227(1):106-17
All references(44)