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Osmr Gene Detail
Summary
  • Symbol
    Osmr
  • Name
    oncostatin M receptor
  • Synonyms
    OSMRB
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330819
    NCBI Gene: 18414
  • Gene Overview
    MyGene.info: OSMR
Location & Maps
more
  • Sequence Map
    Chr15:6813577-6874969 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      61393 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    OSMR, oncostatin M receptor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    OSMR, oncostatin M receptor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IL-31RB, IL-31R-beta, OSMRB, PLCA1
  • Links
    NCBI Gene ID: 9180
    neXtProt AC: NX_Q99650

  • Chr Location
    5p13.1; chr5:38845858-38945579 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2972
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog
  • HCOP
    human homology predictions: OSMR
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human OSMR associations

Human Disease Mouse Models
       Amyloidosis, Primary Localized Cutaneous, 1; PLCA1   OMIM: 105250
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Targeted
    3
  • Transposon induced
    1
  • Genomic Mutations
    1 involving Osmr
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit anemia, decreased hematocrit, and reduced erythroid progenitor, erythrocyte, platelet, and megakaryocyte cells. Homozygotes also show increased susceptibility to diet-induced obesity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040092 VEGA Gene Model | MGI Sequence Detail 61393 C57BL/6J ±  kb
transcript OTTMUST00000104138 VEGA | MGI Sequence Detail 5491 Not Applicable  
polypeptide OTTMUSP00000058250 VEGA | MGI Sequence Detail 971 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    612 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000012060 oncostatin-M-specific receptor subunit beta
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR013783 Immunoglobulin-like fold
    IPR003529 Long hematopoietin receptor, Gp130 family 2, conserved site
Molecular
Reagents
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  • All nucleic 55
    Genomic 1
    cDNA 51
    Primer pair 3

    Microarray probesets 5
References
more
  • Summaries
    All 49
    Developmental Gene Expression 8
    Gene Ontology 6
    Phenotypes 16
  • Earliest
    J:47670 Lindberg RA, et al., Cloning and characterization of a specific receptor for mouse oncostatin M. Mol Cell Biol. 1998 Jun;18(6):3357-67
  • Latest
    J:226167 Guo S, et al., Oncostatin M Confers Neuroprotection against Ischemic Stroke. J Neurosci. 2015 Aug 26;35(34):12047-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory