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Osmr
Gene Detail
 Symbol
Name
ID
Osmr
oncostatin M receptor
MGI:1330819
Synonyms OSMRB
Feature Type protein coding gene
Genetic Map
Chromosome 15
3.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:6813577-6874969 bp, - strand
From VEGA annotation of GRCm38

  61393 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2972  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Osmr

Human
homologs
Human Homolog OSMR, oncostatin M receptor
NCBI Gene ID 9180
neXtProt AC  NX_Q99650
Human Synonyms  OSMRB, PLCA1
Human Chr (Location)  5p13.1; chr5:38845858-38935641 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human OSMR
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(3) Transposon induced(1)
Genomic Mutations involving Osmr (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit anemia, decreased hematocrit, and reduced erythroid progenitor, erythrocyte, platelet, and megakaryocyte cells.
 
Interactions
Osmr interacts with 286 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cell surface receptor signaling pathway, oncostatin-M-mediated signaling pathway, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function cytokine receptor activity, growth factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (61)    Tissues (45)    Images (20)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 40
RT-PCR 21
cDNA source data(49)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(55) Genomic(1) cDNA(51) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000040092 (Evidence)
Ensembl Gene ModelENSMUSG00000022146 (Evidence)
Entrez Gene18414 (Evidence)
UniGene10760
DFCITC1580811, TC1610781
DoTSDT.487678, DT.91330178
NIA Mouse Gene IndexU035985
Consensus CDS ProjectCCDS27368.1
International Mouse Knockout Project StatusOsmr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040092 VEGA Gene Model | MGI Sequence Detail 61393 C57BL/6J ±  kb
transcript OTTMUST00000104138 VEGA | MGI Sequence Detail 5491 Not Applicable 
polypeptide OTTMUSP00000058250 VEGA | MGI Sequence Detail 971 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(12) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(588 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003529 Long hematopoietin receptor, Gp130 family 2, conserved site
Protein Ontology PR:000012060 oncostatin-M-specific receptor subunit beta
References (Earliest) J:47670 Lindberg RA, et al., Cloning and characterization of a specific receptor for mouse oncostatin M. Mol Cell Biol. 1998 Jun;18(6):3357-67
(Latest) J:201766 Komori T, et al., Lack of oncostatin M receptor beta leads to adipose tissue inflammation and insulin resistance by switching macrophage phenotype. J Biol Chem. 2013 Jul 26;288(30):21861-75
All references(46)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory