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Qsox1 Gene Detail
Summary
  • Symbol
    Qsox1
  • Name
    quiescin Q6 sulfhydryl oxidase 1
  • Synonyms
    1300003H02Rik, b2b2673Clo, Qscn6, QSOX
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330818
    NCBI Gene: 104009
  • Gene Overview
    MyGene.info: QSOX1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:155776029-155812889 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      36861 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 67.64 cM, cytoband G3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    QSOX1, quiescin sulfhydryl oxidase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    QSOX1, quiescin sulfhydryl oxidase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Q6, QSCN6
  • Links
    NCBI Gene ID: 5768
    neXtProt AC: NX_O00391
    UniProt: O00391

  • Chr Location
    1q25.2; chr1:180154833-180198034 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 37690
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: QSOX1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Qsox1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    10 images
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for an ENU-induced mutation show cardiovascular phenotypes including persistent truncus arteriosus, atriventricular septal defects and vascular ring, as well as eye defects, short snout, micrognathia, cleft palate, tracheosophageal fistula, polydactyly and spleen hypoplasia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000025411 VEGA Gene Model | MGI Sequence Detail 36861 C57BL/6J ±  kb
    transcript OTTMUST00000062568 VEGA | MGI Sequence Detail 3348 Not Applicable  
    polypeptide OTTMUSP00000030862 VEGA | MGI Sequence Detail 748 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      531 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 133
      cDNA 133

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1914133, MGI:5615572
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 7
      Phenotypes 6
    • Earliest
      J:52083 Coppock DL, et al., The quiescin Q6 gene (QSCN6) is a fusion of two ancient gene families: thioredoxin and ERV1. Genomics. 1998 Dec 15;54(3):460-8
    • Latest
      J:222159 Li Y, et al., Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature. 2015 May 28;521(7553):520-4

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory