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Hsd17b7
Gene Detail
Symbol

Name
ID
Hsd17b7
hydroxysteroid (17-beta) dehydrogenase 7
MGI:1330808
Synonyms
ERG27
Feature Type
protein coding gene
Genetic Map
Chromosome 1
76.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:169949535-169969241 bp, - strand
From VEGA annotation of GRCm38

  19707 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40728  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: HSD17B7
Gene Tree: Hsd17b7

Human
homologs
HSD17B7, hydroxysteroid (17-beta) dehydrogenase 7
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 51478
neXtProt AC: NX_P56937

Human Synonyms: PRAP, SDR37C1

Human Chr (Location): 1q23; chr1:162790702-162812818 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted allele exhibit embryonic lethality, abnormal brain development, abnormal branchial arches, pericardial effusion, and abnormal cardiovascular development.
 
Interactions
Hsd17b7 interacts with 261 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (122)    Tissues (114)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 121
cDNA source data(50)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase hsd17b7    NEW 
Molecular
reagents
All nucleic(52) cDNA(50) Primer pair(2)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000020778 (Evidence)
Ensembl Gene Model ENSMUSG00000026675 (Evidence)
Entrez Gene 15490 (Evidence)
UniGene 12882
DFCI TC1578996, TC1591514, TC1623227, TC1708387
DoTS DT.101391300, DT.101716787, DT.489365
NIA Mouse Gene Index U022027
EC 1.1.1.270, 1.1.1.62
Consensus CDS Project CCDS35766.1
International Mouse Phenotyping Consortium Status Hsd17b7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020778 VEGA Gene Model | MGI Sequence Detail 19707 C57BL/6J ±  kb
transcript OTTMUST00000049129 VEGA | MGI Sequence Detail 1446 Not Applicable 
polypeptide OTTMUSP00000022718 VEGA | MGI Sequence Detail 362 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(362 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002347 Glucose/ribitol dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
Protein Ontology PR:000008783 3-keto-steroid reductase
References
(Earliest) J:48295 Nokelainen P, et al., Expression cloning of a novel estrogenic mouse 17 beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase (m17HSD7), previously described as a prolactin receptor-associated protein (PRAP) in rat. Mol Endocrinol. 1998 Jul;12(7):1048-59
(Latest) J:198874 Layer JV, et al., Characterization of a mutation that results in independence of oxidosqualene cyclase (Erg7) activity from the downstream 3-ketoreductase (Erg27) in the yeast ergosterol biosynthetic pathway. Biochim Biophys Acta. 2013 Feb;1831(2):361-9
All references(43)
Other
accession IDs
MGI:2138189

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory