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Hsd17b7 Gene Detail
Summary
  • Symbol
    Hsd17b7
  • Name
    hydroxysteroid (17-beta) dehydrogenase 7
  • Synonyms
    ERG27
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330808
    NCBI Gene: 15490
  • Gene Overview
    MyGene.info: HSD17B7
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:169949535-169969240 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 76.84 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    357 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330808
protein coding gene Chr1:169949535-169969241 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016723
protein coding gene Chr1:175639154-175658882 (-)
A/J MGP_AJ_G0016703
protein coding gene Chr1:168452734-168472461 (-)
AKR/J MGP_AKRJ_G0016669
protein coding gene Chr1:173532144-173551850 (-)
BALB/cJ MGP_BALBcJ_G0016664
protein coding gene Chr1:168948383-168968089 (-)
C3H/HeJ MGP_C3HHeJ_G0016488
protein coding gene Chr1:173783267-173802995 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017125
protein coding gene Chr1:181451385-181471091 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014834
protein coding gene Chr1:160221211-160240326 (-)
CAST/EiJ MGP_CASTEiJ_G0016068
protein coding gene Chr1:173402606-173424034 (-)
CBA/J MGP_CBAJ_G0016463
protein coding gene Chr1:187906895-187926601 (-)
DBA/2J MGP_DBA2J_G0016569
protein coding gene Chr1:167328934-167348640 (-)
FVB/NJ MGP_FVBNJ_G0016567
protein coding gene Chr1:165704547-165724268 (-)
LP/J MGP_LPJ_G0016640
protein coding gene Chr1:176696461-176716185 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016592
protein coding gene Chr1:195239819-195260757 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017162
protein coding gene Chr1:173419285-173439025 (-)
PWK/PhJ MGP_PWKPhJ_G0015854
protein coding gene Chr1:166557029-166576807 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015640
protein coding gene Chr1:172182924-172202770 (-)
WSB/EiJ MGP_WSBEiJ_G0016130
protein coding gene Chr1:173534539-173554259 (-)



Homology
more
  • Human Ortholog
    HSD17B7, hydroxysteroid 17-beta dehydrogenase 7
  • Vertebrate Orthologs
    11
  • Human Ortholog
    HSD17B7, hydroxysteroid 17-beta dehydrogenase 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PRAP, SDR37C1
  • Links
    NCBI Gene ID: 51478
    neXtProt AC: NX_P56937
    UniProt: P56937

  • Chr Location
    1q23.3; chr1:162790702-162812818 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 3 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit embryonic lethality, abnormal brain development, abnormal branchial arches, pericardial effusion, and abnormal cardiovascular development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15490 NCBI Gene Model | MGI Sequence Detail 19706 C57BL/6J ±  kb
    transcript NM_010476 RefSeq | MGI Sequence Detail 4574 C57BL/6  
    polypeptide O88736 UniProt | EBI | MGI Sequence Detail 334 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      cDNA 51
      Primer pair 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2138189
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 8
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:48295 Nokelainen P, et al., Expression cloning of a novel estrogenic mouse 17 beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase (m17HSD7), previously described as a prolactin receptor-associated protein (PRAP) in rat. Mol Endocrinol. 1998 Jul;12(7):1048-59
    • Latest
      J:240858 Driver AM, et al., Altered cholesterol biosynthesis causes precocious neurogenesis in the developing mouse forebrain. Neurobiol Dis. 2016 Jul;91:69-82

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory