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Hsd17b7 Gene Detail
Summary
  • Symbol
    Hsd17b7
  • Name
    hydroxysteroid (17-beta) dehydrogenase 7
  • Synonyms
    ERG27
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330808
    NCBI Gene: 15490
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:169777109-169796757 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 76.84 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    785 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330808
 protein coding gene Chr1:169777104-169796810 (-)
129S1/SvImJ ENSMUSG00200043327
 protein coding gene Chr1:167257347-167277075 (-)
A/J ENSMUSG00195047078
 protein coding gene Chr1:166575690-166595417 (-)
AKR/J ENSMUSG00220028254
 protein coding gene Chr1:166268720-166288427 (-)
BALB/cJ ENSMUSG00180039722
 protein coding gene Chr1:166835771-166855477 (-)
C3H/HeJ ENSMUSG00175039343
 protein coding gene Chr1:166913742-166933470 (-)
C57BL/6NJ ENSMUSG00215044438
 protein coding gene Chr1:166717803-166737510 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014834
 protein coding gene Chr1:160221211-160240326 (-)
CAST/EiJ ENSTCUG00005045275
 protein coding gene Chr1:165231737-165251572 (-)
CBA/J ENSMUSG00210034000
 protein coding gene Chr1:166801630-166821336 (-)
DBA/2J ENSMUSG00185011637
 protein coding gene Chr1:171018426-171038132 (-)
FVB/NJ ENSMUSG00205023051
 protein coding gene Chr1:165775865-165795593 (-)
JF1/MsJ ENSUMUG00000008036
 protein coding gene Chr1:170161629-170181331 (-)
LP/J ENSMUSG00230026082
 protein coding gene Chr1:170644924-170664760 (-)
NOD/ShiLtJ ENSMUSG00190030153
 protein coding gene Chr1:166576128-166595857 (-)
NZO/HlLtJ ENSMUSG00225002897
 protein coding gene Chr1:174250528-174270376 (-)
PWK/PhJ ENSLUMG00010033913
 protein coding gene Chr1:165545746-165565472 (-)
SPRET/EiJ ENSMSPG00010048723
 protein coding gene Chr1:169118704-169135756 (-)
WSB/EiJ ENSIUOG00005034855
 protein coding gene Chr1:165983673-166003393 (-)



Homology
more
  • Human Ortholog
    HSD17B7, hydroxysteroid 17-beta dehydrogenase 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSD17B7, hydroxysteroid 17-beta dehydrogenase 7
  • Synonyms
    PRAP, SDR37C1
  • Links
    NCBI Gene ID: 51478
    UniProt: P56937

  • Chr Location
    1q23.3; chr1:162790702-162812823 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit embryonic lethality, abnormal brain development, abnormal branchial arches, pericardial effusion, and abnormal cardiovascular development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    765
  • Tissues
    140
  • cDNA Data
    52
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15490 NCBI Gene Model | MGI Sequence Detail 19649 C57BL/6J ±  kb
    transcript NM_010476 RefSeq | MGI Sequence Detail 4554 C57BL/6  
    polypeptide O88736 UniProt | EBI | MGI Sequence Detail 334 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 56
      cDNA 52
      Primer pair 3
      Other 1
      Antibodies 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2138189
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 9
      Gene Ontology 19
      Phenotypes 13
    • Earliest
      J:48295 Nokelainen P, et al., Expression cloning of a novel estrogenic mouse 17 beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase (m17HSD7), previously described as a prolactin receptor-associated protein (PRAP) in rat. Mol Endocrinol. 1998 Jul;12(7):1048-59
    • Latest
      J:371713 Pleshinger MJ, et al., Inhibition of SC4MOL and HSD17B7 shifts cellular sterol composition and promotes oligodendrocyte formation. RSC Chem Biol. 2022 Jan 5;3(1):56-68
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    09/08/2026
    MGI 6.24     		The Jackson Laboratory