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Hsd17b7
Gene Detail
 Symbol
Name
ID
Hsd17b7
hydroxysteroid (17-beta) dehydrogenase 7
MGI:1330808
Synonyms ERG27
Feature Type protein coding gene
Genetic Map
Chromosome 1
76.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:169949535-169969241 bp, - strand
From VEGA annotation of GRCm38

  19707 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40728  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Hsd17b7

Human
homologs
Human Homolog HSD17B7, hydroxysteroid (17-beta) dehydrogenase 7
NCBI Gene ID 51478
neXtProt AC  NX_P56937
Human Synonyms  PRAP, SDR37C1
Human Chr (Location)  1q23; chr1:162790706-162812818 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted allele exhibit embryonic lethality, abnormal brain development, abnormal branchial arches, pericardial effusion, and abnormal cardiovascular development.
 
Interactions
Hsd17b7 interacts with 261 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cholesterol biosynthetic process, lipid metabolic process, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function 3-keto sterol reductase activity, estradiol 17-beta-dehydrogenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (122)    Tissues (114)    Images (13)
Theiler Stages: 17, 19, 20, 21, 22, 23
Assay TypeResults
Immunohistochemistry 1
RNA in situ 121
cDNA source data(50)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(52) cDNA(50) Primer pair(2)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000020778 (Evidence)
Ensembl Gene ModelENSMUSG00000026675 (Evidence)
Entrez Gene15490 (Evidence)
UniGene12882
DFCITC1578996, TC1591514, TC1623227, TC1708387
DoTSDT.101391300, DT.101716787, DT.489365
NIA Mouse Gene IndexU022027
EC1.1.1.270, 1.1.1.62
Consensus CDS ProjectCCDS35766.1
International Mouse Knockout Project StatusHsd17b7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020778 VEGA Gene Model | MGI Sequence Detail 19707 C57BL/6J ±  kb
transcript OTTMUST00000049129 VEGA | MGI Sequence Detail 1446 Not Applicable 
polypeptide OTTMUSP00000022718 VEGA | MGI Sequence Detail 362 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(362 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002347 Glucose/ribitol dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
Protein Ontology PR:000008783 3-keto-steroid reductase
References (Earliest) J:48295 Nokelainen P, et al., Expression cloning of a novel estrogenic mouse 17 beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase (m17HSD7), previously described as a prolactin receptor-associated protein (PRAP) in rat. Mol Endocrinol. 1998 Jul;12(7):1048-59
(Latest) J:198874 Layer JV, et al., Characterization of a mutation that results in independence of oxidosqualene cyclase (Erg7) activity from the downstream 3-ketoreductase (Erg27) in the yeast ergosterol biosynthetic pathway. Biochim Biophys Acta. 2013 Feb;1831(2):361-9
All references(45)
Other
accession IDs
MGI:2138189

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory