Arg2
Gene Detail

Symbol Name ID

Arg2 arginase type II MGI:1330806

Synonyms

AII

Feature Type

protein coding gene

Genetic Map

Chromosome 12

35.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr12:79130777-79156301 bp, + strand From VEGA annotation of GRCm38   25525 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:906  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ureohydrolase/formiminoglutamase/proclavaminate amidino hydrolase
Gene Tree: Arg2

Human homologs

Human Homolog		ARG2, arginase 2
NCBI Gene ID		384
neXtProt AC		NX_P78540
Human Chr (Location)		14q24.1; chr14:68086579-68118437 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Homozygous mutation of this gene results in elevated plasma arginine concentrations.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	arginine catabolic process to ornithine, arginine metabolic process, ...
Component	mitochondrion
Function	arginase activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (204)    Tissues (97)    Images (36)
Theiler Stages: 20, 22, 23

Assay Type	Results
RNA in situ	204

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) cDNA(11) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000033846 (Evidence)
Ensembl Gene Model	ENSMUSG00000021125 (Evidence)
Entrez Gene	11847 (Evidence)
DFCI	TC1580867
NIA Mouse Gene Index	U014139
EC	3.5.3.1
Consensus CDS Project	CCDS26007.1
International Mouse Knockout Project Status	Arg2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033846	VEGA Gene Model | MGI Sequence Detail	25525	C57BL/6J
transcript	OTTMUST00000085291	VEGA | MGI Sequence Detail	1428	Not Applicable
polypeptide	OTTMUSP00000046064	VEGA | MGI Sequence Detail	354	Not Applicable

All sequences(22) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(122 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR014033	Arginase
InterPro	IPR006035	Ureohydrolase
InterPro	IPR023696	Ureohydrolase domain
InterPro	IPR020855	Ureohydrolase, manganese-binding site
Protein Ontology	PR:000004215	arginase-2, mitochondrial

References

(Earliest) J:48418 Iyer RK, et al., Cloning and characterization of the mouse and rat type II arginase genes. Mol Genet Metab. 1998 Mar;63(3):168-75
(Latest) J:194697 Cho WK, et al., IL-13 receptor alpha2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2013 Jan 15;304(2):L112-24
All references(56)

Other accession IDs

MGI:2144959