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Arg2 Gene Detail
Summary
  • Symbol
    Arg2
  • Name
    arginase type II
  • Synonyms
    AII
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330806
    NCBI Gene: 11847
  • Gene Overview
    MyGene.info: ARG2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr12:79130777-79156301 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25525 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 35.51 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ARG2, arginase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARG2, arginase 2
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 384
    neXtProt AC: NX_P78540
    UniProt: P78540

  • Chr Location
    14q24.1; chr14:67619862-67651720 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in elevated plasma arginine concentrations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000033846 VEGA Gene Model | MGI Sequence Detail 25525 C57BL/6J ±  kb
    transcript OTTMUST00000085291 VEGA | MGI Sequence Detail 1428 Not Applicable  
    polypeptide OTTMUSP00000046064 VEGA | MGI Sequence Detail 354 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      194 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144959
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 11
      Gene Ontology 12
      Phenotypes 24
    • Earliest
      J:48418 Iyer RK, et al., Cloning and characterization of the mouse and rat type II arginase genes. Mol Genet Metab. 1998 Mar;63(3):168-75
    • Latest
      J:250841 Zaytouni T, et al., Critical role for arginase 2 in obesity-associated pancreatic cancer. Nat Commun. 2017 Aug 14;8(1):242

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory