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Arg2
Gene Detail
 Symbol
Name
ID
Arg2
arginase type II
MGI:1330806
Synonyms AII
Feature Type protein coding gene
Genetic Map
Chromosome 12
35.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:79130777-79156301 bp, + strand
From VEGA annotation of GRCm38

  25525 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:906  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ureohydrolase/formiminoglutamase/proclavaminate amidino hydrolase
Gene Tree: Arg2

Human
homologs
Human Homolog ARG2, arginase 2
NCBI Gene ID 384
neXtProt AC  NX_P78540
Human Chr (Location)  14q24.1; chr14:67619862-67651720 (+)  GRCh38
Alleles
and
phenotypes
All alleles(1) : Targeted(1)
 
Homozygous mutation of this gene results in elevated plasma arginine concentrations.
 
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process arginine catabolic process to ornithine, arginine metabolic process, ...
Component mitochondrion
Function arginase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (217)    Tissues (106)    Images (49)
Theiler Stages: 20, 21, 22, 23, 25, 28
Assay TypeResults
RNA in situ 217
cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(13) cDNA(12) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000033846 (Evidence)
Ensembl Gene ModelENSMUSG00000021125 (Evidence)
Entrez Gene11847 (Evidence)
DFCITC1580867
NIA Mouse Gene IndexU014139
EC3.5.3.1
Consensus CDS ProjectCCDS26007.1
International Mouse Knockout Project StatusArg2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033846 VEGA Gene Model | MGI Sequence Detail 25525 C57BL/6J ±  kb
transcript OTTMUST00000085291 VEGA | MGI Sequence Detail 1428 Not Applicable 
polypeptide OTTMUSP00000046064 VEGA | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(194 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014033 Arginase
InterPro IPR006035 Ureohydrolase
InterPro IPR023696 Ureohydrolase domain
InterPro IPR020855 Ureohydrolase, manganese-binding site
Protein Ontology PR:000004215 arginase-2, mitochondrial
References (Earliest) J:48418 Iyer RK, et al., Cloning and characterization of the mouse and rat type II arginase genes. Mol Genet Metab. 1998 Mar;63(3):168-75
(Latest) J:194697 Cho WK, et al., IL-13 receptor alpha2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2013 Jan 15;304(2):L112-24
All references(58)
Other
accession IDs
MGI:2144959

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory