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Magoh
Gene Detail
Symbol

Name
ID
Magoh
mago-nashi homolog, proliferation-associated (Drosophila)
MGI:1330312
Synonyms
Mago-m, Mos2
Feature Type
protein coding gene
Genetic Map
Chromosome 4
50.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:107879755-107887424 bp, + strand
From VEGA annotation of GRCm38

  7670 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1776  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: MAGOH
Protein SuperFamily: mago nashi-like protein
Gene Tree: Magoh

Human
homologs
MAGOH, mago homolog, exon junction complex core component
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4116
neXtProt AC: NX_P61326

Human Synonyms: MAGOH1, MAGOHA

Human Chr (Location): 1p32.3; chr1:53226892-53238610 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Chemically induced (ENU)(1) Gene trapped(4) Targeted(8)
Genomic Mutations involving Magoh (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutation in this gene is embryonic lethal and heterozygous mice are postnatal lethal with incomplete penetrance with reduced body size and microcephaly.
 
Interactions
Magoh interacts with 52 markers (Mir16-2, Mir98, Mir188, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process female gamete generation, mRNA processing, ...
Component catalytic step 2 spliceosome, cytoplasm, ...
Function poly(A) RNA binding, RNA binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (18)    Tissues (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
RT-PCR 17
cDNA source data(67)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: GEISHA MAGOH2 ; Xenbase magoh ; ZFIN magoh    NEW 
Molecular
reagents
All nucleic(68) cDNA(67) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000009191 (Evidence)
Ensembl Gene Model ENSMUSG00000028609 (Evidence)
Entrez Gene 17149 (Evidence)
UniGene 808
DFCI TC1575503
DoTS DT.493303, DT.97398468
NIA Mouse Gene Index U004610
Consensus CDS Project CCDS18441.1
International Mouse Phenotyping Consortium Status Magoh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009191 VEGA Gene Model | MGI Sequence Detail 7670 C57BL/6J ±  kb
transcript OTTMUST00000020785 VEGA | MGI Sequence Detail 692 Not Applicable 
polypeptide OTTMUSP00000009528 VEGA | MGI Sequence Detail 146 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(54 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004023 Mago nashi protein
Protein Ontology PR:000010086 protein mago nashi
References
(Earliest) J:113667 Newmark PA, et al., mago nashi mediates the posterior follicle cell-to-oocyte signal to organize axis formation in Drosophila. Development. 1997 Aug;124(16):3197-207
(Latest) J:213515 McMahon JJ, et al., Generation of a Magoh conditional allele in mice. Genesis. 2014 Aug;52(8):752-8
All references(35)
Other
accession IDs
MGI:3822488

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory