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Dmrt2 Gene Detail
Summary
  • Symbol
    Dmrt2
  • Name
    doublesex and mab-3 related transcription factor 2
  • Synonyms
    Terra
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330307
    NCBI Gene: 226049
Location & Maps
more
  • Sequence Map
    Chr19:25672420-25679010 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6591 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    DMRT2, doublesex and mab-3 related transcription factor 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DMRT2, doublesex and mab-3 related transcription factor 2
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 10655
    neXtProt AC: NX_Q9Y5R5

  • Chr Location
    9p24.3; chr9:1003242-1057554 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 17111
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: DMRT2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display perinatal lethality due to breathing difficulties, multiple axial skeletal defects including kinked tails and rib and vertebral malformations, and abnormal somite organization.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000048138 Ensembl Gene Model | MGI Sequence Detail 6591 C57BL/6J ±  kb
transcript ENSMUST00000053068 Ensembl | MGI Sequence Detail 2347 Not Applicable  
polypeptide ENSMUSP00000059654 Ensembl | MGI Sequence Detail 561 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    130 from dbSNP Build 137
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000006543 doublesex- and mab-3-related transcription factor 2
  • InterPro Domains
    IPR001275 DM DNA-binding domain
    IPR026607 DMRT/protein doublesex/protein male abnormal 3
Molecular
Reagents
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  • All nucleic 20
    cDNA 18
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 39
    Developmental Gene Expression 19
    Gene Ontology 8
    Phenotypes 4
  • Earliest
    J:52603 Meng A, et al., A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates. Development. 1999 Mar;126(6):1259-68
  • Latest
    J:213512 Werber M, et al., The tissue-specific transcriptomic landscape of the mid-gestational mouse embryo. Development. 2014 Jun;141(11):2325-30

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory