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Dmrt2
Gene Detail
Symbol

Name
ID
Dmrt2
doublesex and mab-3 related transcription factor 2
MGI:1330307
Synonyms
Terra
Feature Type
protein coding gene
Genetic Map
Chromosome 19
20.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:25672420-25679010 bp, + strand
From Ensembl annotation of GRCm38

  6591 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:17111  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DMRT2
Gene Tree: Dmrt2

Human
homologs
DMRT2, doublesex and mab-3 related transcription factor 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 10655
neXtProt AC: NX_Q9Y5R5

Human Chr (Location): 9p24.3; chr9:1003242-1057554 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display perinatal lethality due to breathing difficulties, multiple axial skeletal defects including kinked tails and rib and vertebral malformations, and abnormal somite organization.
 
Interactions
Dmrt2 interacts with 92 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (19 records)
Data Summary: Results (144)    Tissues (66)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 118
RT-PCR 26
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dmrt2 ; ZFIN dmrt2a, dmrt2b    NEW 
Molecular
reagents
All nucleic(20) cDNA(18) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000048138 (Evidence)
Entrez Gene 226049 (Evidence)
UniGene 275572
DFCI TC1582573
DoTS DT.488610
NIA Mouse Gene Index U019324
Consensus CDS Project CCDS29719.1
International Mouse Phenotyping Consortium Status Dmrt2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000048138 Ensembl Gene Model | MGI Sequence Detail 6591 C57BL/6J ±  kb
transcript ENSMUST00000053068 Ensembl | MGI Sequence Detail 2347 Not Applicable 
polypeptide ENSMUSP00000059654 Ensembl | MGI Sequence Detail 561 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(130 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001275 DM DNA-binding
InterPro IPR026607 DMRT/protein doublesex/protein male abnormal 3
Protein Ontology PR:000006543 doublesex- and mab-3-related transcription factor 2
References
(Earliest) J:52603 Meng A, et al., A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates. Development. 1999 Mar;126(6):1259-68
(Latest) J:213512 Werber M, et al., The tissue-specific transcriptomic landscape of the mid-gestational mouse embryo. Development. 2014 Jun;141(11):2325-30
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory