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Dmrt2
Gene Detail
Symbol

Name
ID
Dmrt2
doublesex and mab-3 related transcription factor 2
MGI:1330307
Synonyms
Terra
Feature Type
protein coding gene
Genetic Map
Chromosome 19
20.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:25672411-25678991 bp, + strand
From NCBI annotation of GRCm38

  6581 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:17111  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dmrt2

Human
homologs
Human Homolog DMRT2, doublesex and mab-3 related transcription factor 2
NCBI Gene ID 10655
neXtProt AC  NX_Q9Y5R5
Human Chr (Location)  9p24.3; chr9:1046757-1057554 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display perinatal lethality due to breathing difficulties, multiple axial skeletal defects including kinked tails and rib and vertebral malformations, and abnormal somite organization.
 
Interactions
Dmrt2 interacts with 92 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process embryonic skeletal system development, positive regulation of myotome development, ...
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (144)    Tissues (66)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 118
RT-PCR 26
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(18) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000048138 (Evidence)
Entrez Gene226049 (Evidence)
UniGene275572
DFCITC1582573
DoTSDT.488610
NIA Mouse Gene IndexU019324
Consensus CDS ProjectCCDS29719.1
International Mouse Knockout Project StatusDmrt2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 226049 NCBI Gene Model | MGI Sequence Detail 6581 C57BL/6J ±  kb
transcript NM_145831 RefSeq | MGI Sequence Detail 2337 C57BL/6 
polypeptide Q8BG36 UniProt | EBI | MGI Sequence Detail 561 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(130 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001275 DM DNA-binding
InterPro IPR026607 DMRT/protein doublesex/protein male abnormal 3
Protein Ontology PR:000006543 doublesex- and mab-3-related transcription factor 2
Graphical View of Protein Domain Structure
References
(Earliest) J:52603 Meng A, et al., A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates. Development. 1999 Mar;126(6):1259-68
(Latest) J:209112 Shimizu H, et al., The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory