About   Help   FAQ
Trpm1 Gene Detail
Summary
  • Symbol
    Trpm1
  • Name
    transient receptor potential cation channel, subfamily M, member 1
  • Synonyms
    4732499L03Rik, LTRPC1, melastatin, Mlsn1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330305
    NCBI Gene: 17364
  • Gene Overview
    MyGene.info: TRPM1
Location & Maps
more
  • Sequence Map
    Chr7:64153835-64269775 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      115941 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 34.61 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TRPM1, transient receptor potential cation channel subfamily M member 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TRPM1, transient receptor potential cation channel subfamily M member 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CSNB1C, LTRPC1, MLSN1
  • Links
    NCBI Gene ID: 4308
    neXtProt AC: NX_Q7Z4N2

  • Chr Location
    15q13.3; chr15:31001061-31161273 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human TRPM1 associations

Human Disease Mouse Models
       Night Blindness, Congenital Stationary, Type 1C; CSNB1C   OMIM: 613216
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 4 alleles in 5 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Trpm1
  • Incidental Mutations
Homozygous mutants have defects in rod and cone electrophysiology affecting the photoresponses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022613 VEGA Gene Model | MGI Sequence Detail 115941 C57BL/6J ±  kb
transcript OTTMUST00000054157 VEGA | MGI Sequence Detail 5076 Not Applicable  
polypeptide OTTMUSP00000025807 VEGA | MGI Sequence Detail 1628 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1171 from dbSNP Build 142
  • PCR
Protein
Information
less
  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000016697 transient receptor potential cation channel subfamily M member 1
  • InterPro Domains
    IPR005821 Ion transport domain
    IPR029588 Transient receptor potential cation channel subfamily M member 1
    IPR032415 TRPM, tetramerisation domain
Molecular
Reagents
less
  • All nucleic 49
    Genomic 3
    cDNA 41
    Primer pair 4
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2142011, MGI:3036274
References
more
  • Summaries
    All 62
    Developmental Gene Expression 9
    Gene Ontology 6
    Phenotypes 32
  • Earliest
    J:51031 Hunter JJ, et al., Chromosomal localization and genomic characterization of the mouse melastatin gene (Mlsn1). Genomics. 1998 Nov 15;54(1):116-23
  • Latest
    J:230947 Xiong WH, et al., The Effect of PKCalpha on the Light Response of Rod Bipolar Cells in the Mouse Retina. Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4961-74

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/23/2016
MGI 6.05
The Jackson Laboratory