Trpm1
Gene Detail

Symbol Name ID

Trpm1 transient receptor potential cation channel, subfamily M, member 1 MGI:1330305

Synonyms

4732499L03Rik, LTRPC1, melastatin, Mlsn1

Feature Type

protein coding gene

Genetic Map

Chromosome 7

34.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr7:64153835-64269775 bp, + strand From VEGA annotation of GRCm38   115941 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:19940  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: transient receptor potential cation channels TRPM1/TRPM3
Gene Tree: Trpm1

Human homologs

Human Homolog		TRPM1, transient receptor potential cation channel, subfamily M, member 1
NCBI Gene ID		4308
neXtProt AC		NX_Q7Z4N2
Human Synonyms		CSNB1C, LTRPC1, MLSN1
Human Chr (Location)		15q13.3; chr15:31293264-31453476 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TRPM1

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Homozygous mutants have defects in rod and cone electrophysiology affecting the photoresponses.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	cellular response to light stimulus, ion transport, ...
Component	integral to membrane, membrane, ...
Function	cation channel activity, ion channel activity

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (99)    Tissues (48)    Images (23)
Theiler Stages: 19, 20, 21, 22, 25, 26, 28

Assay Type	Results
RNA in situ	71
RT-PCR	28

cDNA source data(43)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(52) Genomic(3) cDNA(44) Primer pair(4) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000022613 (Evidence)
Ensembl Gene Model	ENSMUSG00000030523 (Evidence)
Entrez Gene	17364 (Evidence)
UniGene	38875
NIA Mouse Gene Index	U008177
Consensus CDS Project	CCDS21332.2, CCDS39975.2
International Mouse Knockout Project Status	Trpm1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022613	VEGA Gene Model | MGI Sequence Detail	115941	C57BL/6J
transcript	OTTMUST00000054157	VEGA | MGI Sequence Detail	5076	Not Applicable
polypeptide	OTTMUSP00000025807	VEGA | MGI Sequence Detail	1628	Not Applicable

All sequences(481) RefSeq(4) UniProt(7)

Polymorphisms

PCR(1) : SNPs(487 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005821	Ion transport domain
Protein Ontology	PR:000016697	transient receptor potential cation channel subfamily M member 1

References

(Earliest) J:51031 Hunter JJ, et al., Chromosomal localization and genomic characterization of the mouse melastatin gene (Mlsn1). Genomics. 1998 Nov 15;54(1):116-23
(Latest) J:184758 Shen Y, et al., G-protein-mediated inhibition of the Trp channel TRPM1 requires the Gbetagamma dimer. Proc Natl Acad Sci U S A. 2012 May 29;109(22):8752-7
All references(52)

Other accession IDs

MGI:2142011, MGI:3036274