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Trpm1 Gene Detail
Summary
  • Symbol
    Trpm1
  • Name
    transient receptor potential cation channel, subfamily M, member 1
  • Synonyms
    4732499L03Rik, LTRPC1, melastatin, Mlsn1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330305
    NCBI Gene: 17364
  • Gene Overview
    MyGene.info: TRPM1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:64153835-64269775 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      115941 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 34.61 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TRPM1, transient receptor potential cation channel subfamily M member 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TRPM1, transient receptor potential cation channel subfamily M member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CSNB1C, LTRPC1, MLSN1
  • Links
    NCBI Gene ID: 4308
    neXtProt AC: NX_Q7Z4N2
    UniProt: Q7Z4N2

  • Chr Location
    15q13.3; chr15:31001061-31161273 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human TRPM1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 4 alleles in 5 genetic backgrounds
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants have defects in rod and cone electrophysiology affecting the photoresponses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000022613 VEGA Gene Model | MGI Sequence Detail 115941 C57BL/6J ±  kb
    transcript OTTMUST00000054157 VEGA | MGI Sequence Detail 5076 Not Applicable  
    polypeptide OTTMUSP00000025807 VEGA | MGI Sequence Detail 1628 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1171 from dbSNP Build 142
    • PCR
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • InterPro Domains
      IPR005821 Ion transport domain
      IPR029588 Transient receptor potential cation channel subfamily M member 1
      IPR032415 TRPM, tetramerisation domain
      IPR037162 TRPM, tetramerisation domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 48
      Genomic 3
      cDNA 41
      Primer pair 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2142011, MGI:3036274
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 11
      Diseases 2
      Gene Ontology 6
      Phenotypes 38
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:258821 Uddin M, et al., OTUD7A Regulates Neurodevelopmental Phenotypes in the 15q13.3 Microdeletion Syndrome. Am J Hum Genet. 2018 Feb 1;102(2):278-295

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory