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Vps52 Gene Detail
Summary
  • Symbol
    Vps52
  • Name
    VPS52 GARP complex subunit
  • Synonyms
    ARE1, D430041K17Rik, Sacm2l, tclw5, tcl-w5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330304
    NCBI Gene: 224705
  • Gene Overview
    MyGene.info: VPS52
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:33955785-33966495 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330304
protein coding gene Chr17:33955785-33966984 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023549
protein coding gene Chr17:33905772-33918428 (+)
A/J MGP_AJ_G0023510
protein coding gene Chr17:32738911-32749506 (+)
AKR/J MGP_AKRJ_G0023476
protein coding gene Chr17:33133893-33144758 (+)
BALB/cJ MGP_BALBcJ_G0023513
protein coding gene Chr17:32911128-32922266 (+)
C3H/HeJ MGP_C3HHeJ_G0023275
protein coding gene Chr17:33494448-33505043 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023955
protein coding gene Chr17:35188777-35201986 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021433
protein coding gene Chr17:30289074-30290541 (+)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0023380
protein coding gene Chr17:32116372-32126826 (+)
FVB/NJ MGP_FVBNJ_G0023349
protein coding gene Chr17:31983148-31992277 (+)
LP/J MGP_LPJ_G0023458
protein coding gene Chr17:34180426-34190685 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023371
protein coding gene Chr17:35639614-35651012 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023996
protein coding gene Chr17:33462049-33492207 (+)
PWK/PhJ MGP_PWKPhJ_G0022525
protein coding gene Chr17:31031015-31049534 (+)
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    VPS52, VPS52, GARP complex subunit
  • Vertebrate Orthologs
    9
  • Human Ortholog
    VPS52, VPS52, GARP complex subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARE1, dJ1033B10.5, SAC2, SACM2L
  • Links
    NCBI Gene ID: 6293
    neXtProt AC: NX_Q8N1B4
    UniProt: Q8N1B4

  • Chr Location
    6p21.32; chr6:33250272-33271965 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display early embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 224705 NCBI Gene Model | MGI Sequence Detail 10711 C57BL/6J ±  kb
    transcript NM_001357329 RefSeq | MGI Sequence Detail 3625 C57BL/6  
    polypeptide Q8C754 UniProt | EBI | MGI Sequence Detail 723 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 1
      cDNA 22
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14784, MGD-MRK-14804, MGI:2443974, MGI:98531
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 7
    • Earliest
      J:23652 Dunn LC, et al., Studies of the Genetic Variability in Wild Populations of House Mice. I. Analysis of Seven Alleles at Locus T. Genetics. 1956 May;41(3):344-52
    • Latest
      J:225569 Schindler C, et al., EARP is a multisubunit tethering complex involved in endocytic recycling. Nat Cell Biol. 2015 May;17(5):639-50

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory