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Dyrk1b Gene Detail
Summary
  • Symbol
    Dyrk1b
  • Name
    dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
  • Synonyms
    Mirk
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330302
    NCBI Gene: 13549
  • Gene Overview
    MyGene.info: DYRK1B
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:28179469-28187294 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 16.67 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330302
protein coding gene Chr7:28179469-28197910 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031933
protein coding gene Chr7:26948550-26956375 (+)
A/J MGP_AJ_G0031912
protein coding gene Chr7:26296052-26303877 (+)
AKR/J MGP_AKRJ_G0031843
protein coding gene Chr7:26970328-26978153 (+)
BALB/cJ MGP_BALBcJ_G0031918
protein coding gene Chr7:26452110-26460023 (+)
C3H/HeJ MGP_C3HHeJ_G0031640
protein coding gene Chr7:27351260-27359065 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032383
protein coding gene Chr7:27819683-27827508 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029435
protein coding gene Chr7:27394494-27402392 (+)
CAST/EiJ MGP_CASTEiJ_G0030975
protein coding gene Chr7:20643552-20651367 (+)
CBA/J MGP_CBAJ_G0031603
protein coding gene Chr7:29071217-29079022 (+)
DBA/2J MGP_DBA2J_G0031756
protein coding gene Chr7:26059794-26067619 (+)
FVB/NJ MGP_FVBNJ_G0031713
protein coding gene Chr7:26133744-26141561 (+)
LP/J MGP_LPJ_G0031837
protein coding gene Chr7:27281405-27289230 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031748
protein coding gene Chr7:28574574-28582614 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032413
protein coding gene Chr7:26445502-26453327 (+)
PWK/PhJ MGP_PWKPhJ_G0030698
protein coding gene Chr7:21069094-21077018 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030533
protein coding gene Chr7:17437936-17445699 (+)
WSB/EiJ MGP_WSBEiJ_G0031082
protein coding gene Chr7:26781843-26789660 (+)



Homology
more
  • Human Ortholog
    DYRK1B, dual specificity tyrosine phosphorylation regulated kinase 1B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DYRK1B, dual specificity tyrosine phosphorylation regulated kinase 1B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AOMS3, MIRK
  • Links
    NCBI Gene ID: 9149
    neXtProt AC: NX_Q9Y463
    UniProt: Q9Y463

  • Chr Location
    19q13.2; chr19:39825347-39834233 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human DYRK1B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000002409 Ensembl Gene Model | MGI Sequence Detail 7826 C57BL/6J ±  kb
transcript ENSMUST00000172467 Ensembl | MGI Sequence Detail 2523 Not Applicable  
polypeptide ENSMUSP00000133431 Ensembl | MGI Sequence Detail 689 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 18

    Microarray probesets 3
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:50326 Becker W, et al., Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. J Biol Chem. 1998 Oct 2;273(40):25893-902
  • Latest
    J:186425 Masuda T, et al., Cold-inducible RNA-binding protein (Cirp) interacts with Dyrk1b/Mirk and promotes proliferation of immature male germ cells in mice. Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10885-90

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory