About   Help   FAQ
Dyrk2 Gene Detail
Summary
  • Symbol
    Dyrk2
  • Name
    dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
  • Synonyms
    1810038L18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330301
    NCBI Gene: 69181
  • Gene Overview
    MyGene.info: DYRK2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:118855603-118870209 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 66.75 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    132 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330301
protein coding gene Chr10:118855602-118889245 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017768
protein coding gene Chr10:121895687-121905238 (-)
A/J MGP_AJ_G0017743
protein coding gene Chr10:117115010-117124534 (-)
AKR/J MGP_AKRJ_G0017706
protein coding gene Chr10:120599426-120608946 (-)
BALB/cJ MGP_BALBcJ_G0017707
protein coding gene Chr10:117496450-117505974 (-)
C3H/HeJ MGP_C3HHeJ_G0017531
protein coding gene Chr10:120774046-120783600 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018162
protein coding gene Chr10:126034212-126043763 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015843
protein coding gene Chr10:111507177-111516718 (-)
CAST/EiJ MGP_CASTEiJ_G0017092
protein coding gene Chr10:121093957-121103645 (-)
CBA/J MGP_CBAJ_G0017500
protein coding gene Chr10:131126294-131141386 (-)
DBA/2J MGP_DBA2J_G0017606
protein coding gene Chr10:116225284-116234501 (-)
FVB/NJ MGP_FVBNJ_G0017601
protein coding gene Chr10:115232504-115243565 (-)
LP/J MGP_LPJ_G0017680
protein coding gene Chr10:122453831-122464570 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017630
protein coding gene Chr10:133856838-133866365 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018203
protein coding gene Chr10:120625274-120634794 (-)
PWK/PhJ MGP_PWKPhJ_G0016876
protein coding gene Chr10:116325153-116334781 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016667
protein coding gene Chr10:119483088-119492609 (-)
WSB/EiJ MGP_WSBEiJ_G0017152
protein coding gene Chr10:120811825-120821344 (-)



Homology
more
  • Human Ortholog
    DYRK2, dual specificity tyrosine phosphorylation regulated kinase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DYRK2, dual specificity tyrosine phosphorylation regulated kinase 2
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 8445
    neXtProt AC: NX_Q92630
    UniProt: Q92630

  • Chr Location
    12q15; chr12:67648732-67665405 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 48437
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DYRK2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028630 Ensembl Gene Model | MGI Sequence Detail 14607 C57BL/6J ±  kb
transcript ENSMUST00000004281 Ensembl | MGI Sequence Detail 6129 Not Applicable  
polypeptide ENSMUSP00000004281 Ensembl | MGI Sequence Detail 599 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    Genomic 2
    cDNA 7
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:1916431
References
more
  • Summaries
    All 34
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:206403 Weiss CS, et al., DYRK2 negatively regulates cardiomyocyte growth by mediating repressor function of GSK-3beta on eIF2Bepsilon. PLoS One. 2013;8(9):e70848

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/04/2018
MGI 6.13
The Jackson Laboratory